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Diet and functional dyspepsia: Clinical correlates and therapeutic perspectives

World Journal of Gastroenterology 2020年第5期26卷 456-465页

作者： Marcella Pesce Martina Cargiolli Sara Cassarano Barbara Polese Barbara De Conno Laura Aurino Nicola Mancino Giovanni Sarnelli Department of Clinical Medicine and Surgery “Federico II”University of NaplesNaples 80131Italy GI Physiology Unit University College London HospitalLondon NW12BUUnited Kingdom

Hypervigilance and symptoms anticipation,visceral hypersensitivity and gastroduodenal sensorimotor abnormalities account for the varied clinical presentation of functional dyspepsia(FD)*** patients recognize meals as the main triggering factor;thus,dietary manipulations often represent the first-line management strategy in this cohort of ***,scarce quality evidence has been produced regarding the relationship between specific foods and/or macronutrients and the onset of FD symptoms,resulting in nonstandardized nutritional *** dietary advises are indeed empirical and often lead to exclusion diets,reinforcing in patients the perception of“being intolerant”to food and self-perpetuating some of the very mechanisms underlying dyspepsia physiopathology(i.e.,hypervigilance and symptom anticipation).Clinicians are often uncertain regarding the contribution of specific foods to dyspepsia physiopathology and dedicated professionals(i.e.,dietitians)are only available in tertiary referral *** in turn,can result in nutritionally unbalanced diets and could even encourage restrictive eating behaviors in severe *** this review,we aim at evaluating the relationship between dietary habits,macronutrients and specific foods in determining FD *** will provide an overview of the evidence-based nutritional approach that should be pursued in these patients,providing clinicians with a valuable tool in standardizing nutritional advises and discouraging patients from engaging into indiscriminate food exclusions.

关键词： Functional dyspepsia Dietary habits Food intolerances Fermentable oligosaccharides,disaccharides,monosaccharides and polyols gluten-sensitivity Diet

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