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Molecular evaluation of glutathione s transferase family genes in patients with sporadic colorectal cancer

World Journal of Gastroenterology 2018年第39期24卷 4462-4471页

作者： Gabriela Helena Rodrigues-Fleming Glaucia Maria de Mendonca Fernandes Anelise Russo Patrícia Matos Biselli-Chicote Joao Gomes Netinho Erika Cristina Pavarino Eny Maria Goloni-Bertollo Genetics and Molecular Biology Research Unit-UPGEM Sao Jose do Rio Preto Medical SchoolFAMERPSao Jose do Rio PretoSP 15090-000Brazil Department of surgery and Coloproctology Sao Joes do Rio Preto Medical SchoolFAMERPSao Joes do Rio PretoSP 15090-000Brazil

AIM To evaluate the association between polymorphismsin glutathione s transferases(GsTs) and the risk of sporadic colorectal cancer(sCRC), tumor progression and the survival of *** A case-control study of 970 individuals from the Brazilian population was conducted(232 individuals from the case group with colorectal cancer and 738 individuals from the control group without a history of cancer). PCR multiplex and PCR-RFLP techniques were used to genotype the GsT polymorphisms. The tumors were categorized according to the TNM classification: tumor extension(T), affected lymph nodes(N), and presence of metastasis(M). Logistic regression, multiple logistic regression and survival analysis were used to analyze the data. The results are presented in terms of odds ratio(OR) and 95% confidence interval(CI). The level of significance was set at 5%(P ≤ 0.05).REsULTs Age equal to or over 62 years(OR = 8.79; 95%CI: 5.90-13.09, P ssociated with increased risk of sCRC. Analysis of the polymorphisms revealed an association between the GsTM1 polymorphisms and a risk of sCRC(OR = 1.45; 95%CI: 1.06-2.00; P = 0.02), as well as between GsTT1 and a reduced risk of the disease(OR = 0.65; 95%CI: 0.43-0.98; P = 0.04). An interaction between the presence of the wild-type allele of GsTP1 Ile105 Val polymorphism and tobacco consumption on risk of sCRC(OR = 2.33; 95%CI: 1.34-4.05; P = 0.05) was observed. There was an association between the GsTM1 null genotype and the presence of advanced tumors(OR = 2.33; 95%CI: 1.23-4.41; P = 0.009), as well as increased risk of sCRC in the presence of a combination of GsTT1 non-null/GsTM1 null genotypes(OR = 1.50; 95%CI: 1.03-2.19; P = 0.03) and GsTT1 non-null/GsTM1 null/GsTP1 Val~*(OR = 1.85; 95%CI: 1.01-3.36, P = 0.04). Combined GsTT1 non-null/GsTM1 null genotypes(OR = 2.40; 95%CI: 1.19-4.85; P = 0.01) and GsTT1 non-null/GsTM1 null/GsTP1 Val~*(OR = 2.92; 95%CI: 1.05-8.12; P

关键词： Colorectal neoplasms smoking Alcohol glutathione s transferase Genetic polymorphisms

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HEPATIC glutathione s-transferase ACTIVITY IN MOsQUITOFIsH (GAMBUsIA AFFINIs) AND TOPMOUTH GUDGEON (PsEUDORAsOBORA PARVA) EXPOsED TO FENITROTHION

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Journal of Zhejiang University-science A(Applied Physics & Engineering) 2000年第2期 73-78页

作者：樊德方李绍南

Two common fish species, mosquitofish (\%Gambusia affinis\%) and topmouth gudgeon (\%Pseudorasobora parva\%) were exposed to different concentrations of fenitrothion in static system for 96 h. Hepatic glutathione s transferase activity was evaluated after 48 and 96 h pesticide exposure, and was also examined in fish pretreated with pepironyl butoxide and triphenyl phosphate and then exposed to fenitrothion. Results indicated presence of intense glutathione s transferase activity in both species, mosquitofish exhibiting the higher activity. In both species the activity decreased as the concentration of fenitrothion increased, topmouth gudgeon being more susceptible than mosquitofish. In mosquitofish pretreated with pepironyl butoxide, glutathione s transferase activity was increased (11.8%) compared with the control but in topmouth gudgeon it was decreased (21.6%) at the end of 96 h. glutathione s transferase activity was significantly reduced in both species pretreated with triphenyl phosphate at the end of 96 h exposure, topmouth gudgeon being highly susceptible.

关键词： fenitrothion hepatic GsT activity glutathione s transferase fish

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