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No signature of selection on the C-terminal region of glucose transporter 2 with the evolution of avian nectarivory

Avian Research 2020年第4期11卷 380-390页

作者： Alexander M.Myrka Tooba Shah Jason T.Weir Kenneth C.Welch Jr. Department of Cell and Systems Biology University of Toronto25 Harbord St.TorontoON M5S 3G5Canada Department of Biological Sciences University of Toronto Scarborough1265 Military TrailTorontoON M1C 1A4Canada Department of Ecology and Evolutionary Biology University of Toronto Scarborough1265 Military TrailTorontoON M1C 1A4Canada

Background:Flying birds,especially those that hover,need to meet high energetic *** that meet this demand through nectarivory face the added challenges of maintaining homeostasis in the face of spikes in blood sugar associated with nectar meals,as well as transporting that sugar to energetically demanding *** has evolved many times in birds and we hypothesized that the challenges of this dietary strategy would exert selective pressure on key aspects of metabolic ***,we hypothesized we would find convergent or parallel amino acid substitutions among different nectarivorous lineages in a protein important to sensing,regulating,and transporting glucose,glucose transporter 2(GLUT2).Methods:Genetic sequences for GLUT2 were obtained from ten pairs of nectarivorous and non-nectarivorous sister *** performed PCR amplification of the intracellular C-terminal domain of GLUT2 and adjacent protein domains due to the role of this region in determination of transport rate,substrate specificity and ***:Our findings have ruled out the C-terminal regulatory region of GLUT2 as a target for selection by sugar-rich diet among avian nectarivores,though selection among hummingbirds,the oldest avian nectarivores,cannot be ***:Our results indicate future studies should examine down-stream targets of GLUT2-mediated glucosensing and insulin secretion,such as insulin receptors and their targets,as potential sites of selection by nectarivory in birds.

关键词： GLUT2 Nectarivory Avian glucosensing Glucose Diet Insulin signalling

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