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Nano Research 2022年第2期15卷 1587-1592页

作者： Chengyi Hong Lingling Chen Chenyue Wu Dan Yang Jia-Yong Dai Zhiyong Huang Ren Cai Weihong Tan College of Food and Biological Engineering Fujian Provincial Key Laboratory of Food Microbiology and Enzyme EngineeringJimei UniversityXiamen 361021China Molecular Science and Biomedicine Laboratory State Key Laboratory for Chemo/Bio-Sensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of Biology College of Material Science and Engineeringand Collaborative Research Center of Molecular Engineering for TheranosticsHunan UniversityChangsha 410082China RMIT University MelbourneVIC 3000Australia Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province Sir Run Run Shaw HospitalMedical College of Zhejiang UniversityHangzhou 310016China

We report a colorimetric method for glucose detection based on Au nanoparticle-decorated WSe_(2)(Au@WSe_(2))hybrid nanostructures.These hybrid structures are easily synthesized by simply stirring HAuCl_(4) precursor with WSe_(2) nanosheets in aqueous solution.Owing to strong synergistic catalytic effects of Au nanoparticles and WSe_(2) nanosheets,the Au@WSe_(2) hybrid nanostructures exhibit enhanced peroxidase-like activity(about 2-fold higher compared to WSe_(2) nanosheets alone)for 3,3',5,5'-tetramethylbenzidine oxidation by H_(2)O_(2).Based on the highly catalytical property,the colorimetric method for glucose detection is established by coupling glucose oxidase(GOx).The detection limit of glucose is 3.66 pM.Moreover,the proposed colorimetric method is applicable to glucose detection in serum samples and is promising for applications in biomedical fields.

关键词： Hybrid nanomaterials peroxidase-like activity two-dimensional nanomaterials glucose detection

Universal peroxidase-like strategy for sensitive glucose detection in complex matrix

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Nano Research 2023年第1期16卷 1141-1148页

作者： Guohua Jiang Zhaoyan Yang Kai Zhu Shenfei Zong Lei Wu Zhuyuan Wang Yiping Cui Advanced Photonics Center Southeast UniversityNanjing 210096China

glucose detection in complex matrix such as physiological fluids and drinks can provide useful information guide for people.However,traditional detection methods toward complex matrix suffer from the impurity interference or complex pretreatments.So,it is important to exploit a universal and sensitive glucose detection strategy in complex matrix.In this work,a cascade catalytic scheme based on peroxidase-like MBs@MIL-100(Fe)@Ag(MMA)is developed for sensitive glucose detection in complex solution.Using 3,3’,5,5’-tetramethylbenzidine(TMB)as an indicator,MMA can trigger catalytic cascade reactions for specific glucose sensing.In particular,the peroxidase-like MIL-100(Fe)serves as both the catalysis unit and enrichment unit.Oxidation state of TMB(oxTMB)can be effectively and specifically enriched by MIL-100(Fe)to exclude the interference of undesired impurities and macromolecules,which is suitable for complex sample matrix including colored soda and saliva.In addition,utilizing the peroxidase-like activity of MIL-100(Fe)for self-clean,the residual indicator molecules can be degraded,resulting in the recyclable use of MMA.

关键词： surface enhanced Raman scattering complex matrix MIL-100(Fe) glucose detection recyclable

Polydopamine-Based Colorimetric Superwettable Biosensor for Highly Sensitive detection of Hydrogen Peroxide and glucose

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Journal of Analysis and Testing 2023年第2期7卷 118-127页

作者： Jinze Li Yuhao Li Zhongfeng Gao Key Laboratory of Interfacial Reaction and Sensing Analysis in Universities of Shandong School of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China College of Chemistry and Chemical Engineering Linyi UniversityLinyi 276005China

Superwettable surface has broad application prospects in fabricating biosensors due to its significant enrichment effect.Here,we report a polydopamine-based colorimetric superwettable sensor that integrates superhydrophobic-superhydrophilic micropatterns for the determination of hydrogen peroxide(H_(2)O_(2))and glucose.Dopamine can be oxidized into polydopamine with the addition of horseradish peroxidase(HRP)and H_(2)O_(2),leading to the deposited spots color change from colorless to black.The concentration of target can be determined by analyzing RGB value using a smartphone software.The superhydrophobic area on the superwettable surface helps capture droplets by confining them to superhydrophilic microwells.After droplet evaporation,the analytes are concentrated in the small superhydrophilic domain,thus greatly enhancing the sensitivity.The experimental results manifested that superwettable sensor is able to detect H_(2)O_(2)with a broad linear range of 0.25μmol/L-25 mmol/L and a low limit of detection(LOD)of 0.25μmol/L by naked eye.For glucose detection,the linear range of the sensor is from 2μmol/L to 20 mmol/L and LOD is 0.69μmol/L.The superwettable sensor has been successfully applied in practical samples,including cancerous cells,milk,urine,and human serum samples with acceptable results.This superwettable sensor has several merits,such as high sensitivity,rapid response,and low sample volume in a single microdroplet,and shows great potential in manufacturing portable devices for complex biosensing applications.

关键词： Colorimetric assay Polydopamine Hydrogen peroxide glucose detection Superwettable sensor

Synergistic effect enhances the peroxidase-like activity in platinum nanoparticle-supported metal—organic framework hybrid nanozymes for ultrasensitive detection of glucose

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Nano Research 2021年第12期14卷 4689-4695页

作者： Jing Li Jie Zhao Shengqiang Li Yang Chen Weiqiang Lv Jiahui Zhang Libing Zhang Zhen Zhang Xiaoquan Lu Tianjin Key Laboratory of Molecular Optoelectronic Department of ChemistrySchool of ScienceTianjin UniversityTianjin300072China Key Laboratory of Bioelectrochemistry&Environmental Analysis of Gansu Province College of Chemistry&Chemical EngineeringNorthwest Normal UniversityLanzhou730070China First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin Tianjin300000China School of Physics University of Electronic Science and TechnologyChengdu611731China

The metal—organic frameworks(MOFs)are expected as ideal biomimetic enzymes for colorimetric glucose detection because of their large surface areas,well defined pore structures,tunable chemical composition,and multi-functional sites.However,the intrinsically chemical instability and low mimetic enzyme activity of MOFs hinder the application of them in imitating the enzyme reactions.In this work,we demonstrated a metal-MOF synergistic catalysis strategy,by loading Pt nanoparticles(Pt NPs)on MIL-88B-NH2(Fe-MOF)to increase peroxidase-like activity for the detection of glucose.The induced electrons transfer from Pt atom to Fe atom accelerated the redox cycling of Fe^(3+)/Fe^(2+),improved the overall efficiency of the peroxidase-like reaction,and enabled the efficient and robust colorimetric glucose detection,which was proved by both experiments and density functional theory(DFT)calculation.Additionally,the sensitivity and chemical stability of this synergistic effect strategy to detect the glucose are not affected by the complex external factors,which represented a great potential in fast,easy,sensitive,and specific recognition of clinical diabetes.

关键词： metal—organic frameworks Pt nanoparticles synergistic effect glucose detection

A graphene-laminated electrode with high glucose oxidase loading for highly-sensitive glucose detection

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Journal of Materials Science & Technology 2021年第7期66卷 57-63页

作者： Yabin Hao Minghe Fang Chuan Xu Zhe Ying Han Wang Rui Zhang Hui-Ming Cheng You Zeng Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Liaoning Cancer Hospital and Institute Shenyang 110042China Shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen InstituteShenzhen 518055China

Graphene oxide(GO) has received considerable attention for glucose detection because of high surface area, abundant functional groups, and good biocompatibility. Defects and functional groups of the GO are beneficial to immobilization of glucose oxidase(GOD), but sacrificing electron-transfer capability for highly-sensitive detection. In order to obtain high GOD loading and highly-sensitive detection of biosensors, we first designed and fabricated a graphene-laminated electrode by combining GO and edgefunctionalized graphene(FG) layers together onto glassy-carbon electrode. The graphene-laminated electrodes exhibited faster electron transfer rate, higher GOD loading of 3.80 × 10^(-9) mol·cm^(-2), and higher detection sensitivity of 46.71 μA·mM^(-1)·cm^(-2) than other graphene-based biosensors reported in literature. Such high performance is mainly attributed to the abundant functional groups of GO, high electrical conductivity of FG, and strong interactions between components in the graphene-laminated electrodes.By virtue of their high enzyme loading and highly-sensitive detection, the graphene-laminated electrodes show great potential to be widely used as high-performance biosensors in the field of medical diagnosis.

关键词： Graphene Laminated structure Electrode glucose detection Biosensor

Ultrastable and ultrasensitive pH-switchable carbon dots with high quantum yield for water quality identification,glucose detection,and two starch-based solid-state fluorescence materials

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Nano Research 2020年第11期13卷 3012-3018页

作者： Daiyong Chao Jinxing Chen Qing Dong Weiwei Wu Desheng Qi Shaojun Dong College of Chemistry Jilin UniversityChangchun130012China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China

It is attractive and encouraging to develop new fluorescent carbon dots(CDs)with excellent optical properties and promising applications prospects.Herein,highly-efficient green emissive CDs(m-CDs)with a high quantum yield(QY)of 71.7%in water are prepared through a facile solvothermal method.Interestingly,the m-CDs exhibit excellent fluorescence stability in the pH range of 1–9.However,the fluorescence intensity of the m-CDs is almost completely quenched as the pH is increased from 9 to 10.The mechanism of the unique pH-responsive behavior is discussed in detail and a plausible mechanism is proposed.Owing to the unique pH-responsive behavior,the m-CDs are used as a on-off fluorescent probe for water quality identification.By combining the reversible pH-ultrasensitive optical properties of the m-CDs in the pH range of 9–10 with the glucose oxidase-mimicking(GOx-mimicking)ability of Au nanoparticles(AuNPs),glucose can be quantitatively detected.Finally,two environment-friendly starch-based solid-state fluorescence materials(powder and film)are developed through green preparation routes.

关键词： carbon dot high quantum yield pH-ultrasensitive optical properties water quality identification glucose detection solid-state fluorescence materials

Self-assembled all-inclusive organic-inorganic nanoparticles enable cascade reaction for the detection of glucose

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Chinese Chemical Letters 2021年第5期32卷 1780-1784页

作者： Ximei Sun Yan Li Qian Yang Yunwei Xiao Yuting Zeng Jindi Gong Ziyu Wang Xiaofeng Tan He Li College of Optoelectronics Technology Chengdu University of Information TechnologyChengdu 610225China School of Pharmacy Chengdu Medical CollegeChengdu 610500China Chengdu No.7 High School Chengdu 610041China School of Chemistry and Chemical Engineering University of Ji'nanJi'nan 250022China

Traditional colorimetric glucose biosensor generally involves complex assay procedures.Free labile enzymes and peroxidase substrates are used separately for triggering a chromogenic reaction.These limits result in inferior enzyme stability and defective enzymatic catalytic efficiency,making it hard to routinely utilize them for the direct and fast test of glucose.In this work,we provide an all-inclusive substrates/enzymes nanoparticle employed 3,3’5,5’-tetramethylbenzidine(TMB) as chromogenic substrates and glucose oxidase(GOx)/horseradish peroxidase(HRP) as signal amplifier enzymes(TMB-GH NPs) by the molecule self-assembly technique.The "all-inclusive" nanoparticles can realize the tandem colorimetric reactions,and the oxidation product of TMB(ox-TMB) exhibits a strong NIR laserdrive n photothermal effect,thus allowing qua ntitative photothermal detection of glucose.Owing to the restriction of the molecular motion of GOx,HRP,and TMB,the distance of mass transfer between substrates was s hortened largely,leading to improved catalytic activity for glucose.Overall,our strategy will simplify the analysis procedure,furthermore,these integrated nanoparticles not only display higher stability and activity than that of the free GOx/HRP system and possesses an excellent performance for colorimetric and photothermal bioassay of glucose simultaneously.We believe that this unique technique will give good inspirations to develop simple and precise methods for bioassay.

关键词： Self-assembly All-inclusive nanoparticles glucose detection Colorimetric and photothermal bioassay Chromogenic substrates

A paper-based microfluidic biosensor integrating zinc oxide nanowires for electrochemical glucose detection

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Microsystems & Nanoengineering 2015年第1期1卷 112-118页

作者： Xiao Li Chen Zhao Xinyu Liu Department of Mechanical Engineering McGill UniversityMontrealCanada

This paper reports an electrochemical microfluidic paper-based analytical device(EμPAD)for glucose detection,featuring a highly sensitive working electrode(WE)decorated with zinc oxide nanowires(ZnO NWs).In addition to the common features ofμPADs,such as their low costs,high portability/disposability,and ease of operation,the reported EμPAD has three further advantages.(i)It provides higher sensitivity and a lower limit of detection(LOD)than previously reportedμPADs because of the high surface-to-volume ratio and high enzyme-capturing efficiency of the ZnO NWs.(ii)It does not need any light-sensitive electron mediator(as is usually required in enzymatic glucose sensing),which leads to enhanced biosensing stability.(iii)The ZnO NWs are directly synthesized on the paper substrate via low-temperature hydrothermal growth,representing a simple,low-cost,consistent,and mass-producible process.To achieve superior analytical performance,the on-chip stored enzyme(glucose oxidase)dose and the assay incubation time are tuned.More importantly,the critical design parameters of the EμPAD,including the WE area and the ZnO-NW growth level,are adjusted to yield tunable ranges for the assay sensitivity and LOD.The highest sensitivity that we have achieved is 8.24μA·mM^(−1)·cm^(−2),with a corresponding LOD of 59.5μM.By choosing the right combination of design parameters,we constructed EμPADs that cover the range of clinically relevant glucose concentrations(0−15 mM)and fully calibrated these devices using spiked phosphate-buffered saline and human serum.We believe that the reported approach for integrating ZnO NWs on EμPADs could be well utilized in many other designs of EμPADs and provides a facile and inexpensive paradigm for further enhancing the device performance.

关键词： electrochemical detection enzymatic biosensor glucose detection paper-based microfluidics zinc oxide nanowire

Self-Powered Implantable Skin-Like Glucometer for Real-Time detection of Blood glucose Level In Vivo

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Nano-Micro Letters 2018年第2期10卷 151-161页

作者： Wanglinhan Zhang Linlin Zhang Huiling Gao Wenyan Yang Shuai Wang Lili Xing Xinyu Xue College of Sciences Northeastern University College of Life and Health Sciences Northeastern University

Implantable bioelectronics for analyzing physiological biomarkers has recently been recognized as a promising technique in medical treatment or diagnostics. In this study, we developed a self-powered implantable skinlike glucometer for real-time detection of blood glucose level in vivo. Based on the piezo-enzymatic-reaction coupling effect of GOx@ZnO nanowire, the device under an applied deformation can actively output piezoelectric signal containing the glucose-detecting information. No external electricity power source or battery is needed for this device, and the outputting piezoelectric voltage acts as both the biosensing signal and electricity power. A practical application of the skin-like glucometer implanted in mouse body for detecting blood glucose level has been simply demonstrated. These results provide a new technique path for diabetes prophylaxis and treatment.

关键词： Diabetes Biosensor Electronic-skin Self-powered glucose detection Implantable electronics

A novel fluorescence resonance energy transfer biosensor for sensitive detection of glucose based on MnO2 nanosheets-copper nanoclusters nanoprobes

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A novel fluorescence resonance energy transfer biosensor for...