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Starch supplementation improves the reproductive performance of sows in different glucose tolerance status

Animal Nutrition 2021年第4期7卷 1231-1241页

作者： Yunyu Yang Ming Deng Jianzhao Chen Xichen Zhao Kaili Xiao Wenliang He Xinggang Qiu Yanzhen Xu Yulong Yin Chengquan Tan Guangdong Provincial Key Laboratory of Animal Nutrition Control National Engineering Research Center for Breeding Swine IndustryInstitute of Subtropical Animal Nutrition and FeedGuangzhouGuangdong 510642China Departments of Animal Science and of Veterinary Integrative Biosciences Texas A&M UniversityCollege StationTX77843USA National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production Institute of Subtropical AgricultureChinese Academy of SciencesChangshaHunan 410125China Guangdong Natural Industry Co. Ltd.GuangzhouGuangdong 511363China Center of Experimental Teaching for Basic Courses South China Agricultural UniversityGuangzhou 510642China Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhouGuangdong 510642China College of Animal Science South China Agricultural UniversityGuangzhouGuangdong 510642China

This study was to evaluate the effects of glucose tolerance status,maternal starch supplementation and soybean substitution in diets on the performance of dams and their ***-eight pregnant sows(Landrace x Large White)were selected from an initial total of 120 sows,based on blood glucose test values,and assigned to 4 experimental treatments in a 2×2 factorial *** factors were glucose tolerance status(glucose intolerant[GIT]*** glucose tolerant[NGT])or dietary treatments(corn starch diet[CS]*** substitution diet[SSI]).A higher area under the curve(AUC)for post-meal glucose was observed(Pglucose tolerance *** villus height of the jejunum and the villus height to crypt depth ratio of the ileum were greater in normal birth weight piglets from the CS group than from the SS group(Pglucose tolerance ***,the CS group improved birth weight distribution and decreased pre-weaning mortality rate of piglets under GIT status.

关键词： glucose tolerance Insulin resistance Sow Starch Soybean substitution Stillbirth rate

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Helianthus tuberosus(Jerusalem artichoke) tubers improve glucose tolerance and hepatic lipid profile in rats fed a high-fat diet

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Asian Pacific Journal of Tropical Medicine 2017年第5期10卷 418-422页

作者： Naoto Okada Shinya Kobayashi Kouta Moriyama Kohsuke Miyataka Shinji Abe ChiemiSato Kazuyoshi Kawazoe Department of Clinical Pharmacy Practice Pedagogy Institute of Biomedical SciencesTokushima University Graduate School Department of Pharmacy Tokushima University Hospital Faculty of Pharmaceutical Sciences Tokushima University Faculty of Medicine Tokushima University

Objective:To analyze the effects of feeding Helianthus tuberosus(HT) tubers on glucose tolerance and lipid profile in rats fed a high-fat diet(HFD). Methods:A normal HFD or HFD including 10 w/w% HT tubers(HFD + HT) was fed to F334/Jcl rats. After 10 weeks,organ weights,glucose tolerance,and lipid profile were analyzed. Results:The body weight,liver weight,and epidermal fat content in the HFD group were higher than those of the normal group,and similar to those of the HFD + HT group. The oral glucose tolerance test at 10 weeks revealed that the blood glucose level 30 minutes after beginning the test in the HFD + HT group was significantly lower than that in the HFD group. Liver triglyceride and total cholesterol levels in the HFD + HT group were significantly lower than those in the HFD group. Fecal triglyceride and total cholesterol levels in the HFD + HT group were higher than those in the HFD group. Histological analyses revealed that fat and glycogen accumulation increased in the HFD group,but decreased in the HFD + HT group. Conclusions:These results indicate that HT tubers have anti-fatty liver effects based on improvements in glucose tolerance and the hepatic lipid profile.

关键词： Helianthus tuberosus glucose tolerance Hepatic lipid profile

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Effects of dietary macronutrients and body composition on glucose homeostasis in mice

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National Science Review 2021年第1期8卷 19-29页

作者： Sumei Hu Jacques Togo Lu Wang Yingga Wu Dengbao Yang Yanchao Xu Li Li Baoguo Li Min Li Jianbo Li Guanlin Wang Xueying Zhang Chaoqun Niu Mohsen Mazidi Alex Douglas John R.Speakman State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Institute of Biological and Environmental Sciences University of Aberdeen Key Laboratory of Molecular Pharmacology and Drug Evaluation (Ministry of Education of China) School of Pharmacy Yantai University School of Basic Medical Sciences University of Dali University of Chinese Academy of Sciences CAS Center for Excellence in Animal Evolution and Genetics (CCEAEG)

As a major health issue, obesity is linked with elevated risk of type 2 diabetes. However, whether disrupted glucose homeostasis is due to altered body composition alone, or whether dietary macronutrients play an additional role, independent of their impact on body composition, remains unclear. We investigated the associations between macronutrients, body composition, blood hormones and glucose homeostasis. We fed C57BL/6N mice 29 different diets with variable macronutrients for 12 weeks. After 10 weeks,intraperitoneal glucose tolerance tests were performed. Generalized linear models were generated to evaluate the impacts of macronutrients, body composition and blood hormones on glucose *** area under the glucose curve (AUC) was strongly associated with body fat mass, but not dietary macronutrients. AUC was significantly associated with fasting insulin levels. Six genes from transcriptomic analysis of epididymal white adipose tissue and subcutaneous white adipose tissue were significantly associated with AUC. These genes may encode secreted proteins that play important previously unanticipated roles in glucose homeostasis.

关键词： dietary macronutrients body fat mass fasting blood glucose glucose tolerance mice

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Early diabetic neuropathy:Triggers and mechanisms

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World Journal of Gastroenterology 2007年第2期13卷 175-191页

作者： Maxim Dobretsov Dmitry Romanovsky Joseph R Stimers Departments of Anesthesiology Neurobiology and Developmental Sciences University of Arkansas for Medical Sciences 4301 West Markham Street Little Rock AR 72205 United States Department of Anesthesiology University of Arkansas for Medical Sciences 4301 West Markham Street Little Rock AR 72205 United States Department of Pharmacology and Toxicology University of Arkansas for Medical Sciences 4301 West Markham Street Little Rock AR 72205 United States

Pedpheral neuropathy, and specifically distal peripheral neuropathy （DPN）, is one of the most frequent and troublesome complications of diabetes mellitus. It is the major mason for morbidity and mortality among diabetic patients. It is also frequently associated with debilitating pain. Unfortunately, our knowledge of the natural history and pathogenesis of this disease remains limited. For a long time hyperglycemia was viewed as a major, if not the sole factor, responsible for all symptomatic presentations of DPN. Multiple clinical observations and animal studies supported this view. The control of blood glucose as an obligatory step of therapy to delay or reverse DPN is no longer an arguable issue. However, while supporting evidence for the glycemic hypothesis has accumulated, multiple controversies accumulated as well. It is obvious now that DPN cannot be fully understood without considering factors besides hyperglycemia. Some symptoms of DPN may develop with little, if any, correlation with the glycemic status of a patient. It is also dear that identification of these putative non-glycemic mechanisms of DPN is of utmost importance for our understanding of failures with existing treatments and for the development of new approaches for diagnosis and therapy of DPN. In this work we will review the strengths and weaknesses of the glycemic hypothesis, focusing on dinical and animal data and on the pathogenesis of early stages and triggers of DPN other than hyperglycemia.

关键词： glucose tolerance Hyperglycemia Insulinopenia Insulinresistance

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Jiawei Erzhiwan improves menopausal metabolic syndrome by enhancing insulin secretion in pancreatic β cells

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Chinese Journal of Natural Medicines 2016年第11期14卷 823-834页

作者： WAN Xiao-Meng ZHANG Mu ZHANG Pei XIE Zhi-Shen XU Feng-Guo ZHOU Ping MA Shi-Ping XU Xiao-Jun State Key Laboratory of Natural Medicine China Pharmaceutical University Nanjing 210009 China Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases Nanjing 210009 China

Menopausal metabolic syndrome(MMS) is a series of syndrome caused by ovarian function decline and hormone insufficiency, and is a high risk factor for cardiovascular diseases(CVD) and type II diabetes mellitus(T2DM). Erzhiwan(EZW),composed of Herba Ecliptae and Fructus Ligustri Lucidi, is a traditional Chinese herbal formula that has been used to treat menopausal syndrome for many years. We added Herba Epimedii, Radix Rehmanniae, and Fructus Corni into EZW, to prepare a new formula, termed Jiawei Erzhiwan(JE). The present study was designed to determine the anti-MMS effects of JE using ovariectomized(OVX) adult female rats that were treated with JE for 4 weeks, and β-tc-6 cells and INS cells were used to detected the protect effectiveness of JE. Our results showed JE could increase insulin sensitivity and ameliorated hyperlipidemia. Metabolomics analysis showed that the serum levels of branched and aromatic amino acids were down-regulated in serum by JE administration. Moreover, JE enhanced the function of islet βcells INS-1 and β-tc-6, through increasing the glucose stimulated insulin secretion(GSIS), which was abolished by estrogen receptor(ER)antagonist, indicating that JE functions were mediated by ER signaling. Additionally, JE did not induce tumorigenesis in rat mammary tissue or promoted proliferation of MCF-7 and Hela cells. In conclusion, our work demonstrated that JE ameliorated OVX-induced glucose and lipid metabolism disorder through activating estrogen receptor pathway and promoting GSIS in islet β cells, thus indicating that JE could be a safe and effective medication for MMS therapy.

关键词： Jiawei Erzhiwan Menopausal metabolic syndrome Estrogen receptor glucose tolerance Islet β cell

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A comparative study on the tolerance of tilapia(Oreochromis niloticus)to high carbohydrate and high lipid diets

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Animal Nutrition 2023年第2期13卷 160-172页

作者： Lijun Ning Haotian Zhang Xiaoying Chen Jia Zhen Sen Chen Junfeng Guang Chao Xu Yuanyou Li University Joint Laboratory of Guangdong Province Hong Kong and Macao Region on Marine Bioresource Conservation and ExploitationCollege of Marine SciencesSouth China Agricultural University&Maoming BranchGuangdong Laboratory for Lingnan Modern AgricultureGuangzhou 510642GuangdongChina Laboratory of Aquatic Sciences Key Laboratory of Animal Nutrition and Feed Science in South China of Ministry of Agriculture and Rural AffairsGuangdong Key Laboratory of Animal Breeding and NutritionInstitute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou 510640China

A 12-wk trial was conducted to compare the tolerance of tilapia to high carbohydrate and high lipid *** isonitrogenous and isoenergetic diets,whose carbohydrate and lipid levels were the following:35.0%and 8%(control),44.2%and 4%(D1,high carbohydrate),and 25.8%and 12%(D2,high lipid),*** hundred tilapias(27±0.11 g)were fed the diets for 10 wk(4 replicates per group);72 fish from the D1 group were continually fed the D1(D1D1)and 72 fish from the D2 were continually fed the D2(D2D2)diet for 2 wk(3 replicates each group)to evaluate the tilapia's capacity to tolerate high carbohydrate and high lipid diets,*** 36 fish from D1 group were continually fed D2(D1D2)for comparison with D1D1 and D2D2 *** phase 1,hepatosomatic index,liver triglycerides(TG),glucose tolerance(GT)and crude protein in the whole body in D1 group were higher than those in D2 group(Pglucose and GT were higher in D1D1 and D1D2 groups than those in D2D2 group(Ptolerance to a high lipid diet than high carbohydrate diet;2)despite retention of glucose tolerance,the continuous feeding of D1 diet impaired tilapia's appetite,weight gain rate and host immune response;3)specific distri-bution of fat in intraperitoneal regions,SCAT and liver may be a risk-avoidance strategy in tilapia in response to a continuous D2 diet.

关键词： Keywords:Carbohydrate and lipid Tilapia glucose tolerance Subcutaneous adipose tissue

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The Prevalence of NIDDM and IGT and Related Factors Among Residents in Some Areas of Hubei Province, China

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Biomedical and Environmental Sciences 2000年第2期13卷 148-153页

作者： WANGZENG－ZHEN JINZHI－XIN 等 DeptartmentofPreventiveMedicine TongjiMedicalUniversityWuhan430030China InstituteofEndocrine TongjiHospitalTongjiMedicalUniversityWuhan430030China

The epidemiological survey of prevalence of NIDDM (non_insulin dependent diabetes mellitus) and IGT(impaired glucose tolerance)was conducted among 9450 residents aged 25～70 in some areas of Hubei Province, China. The results show that NIDDM and IGT prevalences are 2.62% and 4.48%, respectively. There is no significant difference between male and female ( P >0.05). The NIDDM prevalence in cities is slightly higher than that in countryside, but the difference is not significant ( P >0.05). However, the IGT prevalence in city is significantly higher than that in countryside ( P <0.01). The prevalence of both NIDDM and IGT is increasing along with the age of the population. It is also significantly related to the family history of NIDDM, hypertension, and high body mass index (BMI). By using stepwise logistic regression to analyse the risk factors of NIDDM, age ( OR =1.86),BMI( OR =2.69), family history ( OR =2.84) and hypertension \{( OR =2.23)\} entered the model (significance level is α =0.05)

关键词： Hubei Province epidemiological survey logistic regression glucose tolerance diabetes mellitus body mass index risk factors

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A comparative study to determine the effects of breed and feed restriction on glucose metabolism of chickens

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Animal Nutrition 2023年第2期13卷 261-269页

作者： Pengfei Du Huanjie Wang Xiuwen Shi Xiangli Zhang Yao Zhu Wen Chen Huaiyong Zhang Yanqun Huang College of Animal Science and Technology Key Laboratory of Animal Biochemistry and NutritionMinistry of AgricultureHenan Agricultural UniversityZhengzhou 450002HenanChina Laboratory for Animal Nutrition and Animal Product Quality Department of Animal Sciences and Aquatic EcologyGhent UniversityGhent9000Belgium

The glucose metabolism of poultry draws wide attention as they have nearly twice the fasting blood glucose than that of *** define the relationship between glucose metabolism and breed of chicken,the outcomes from different growth rate chickens showed that Arbor Acres(AA)broilers,a well-known fast-growing breed,had a lower fasting blood glucose concentration and glucose clearance rate when compared to Silky chickens,a Chinese traditional medicinal chicken with black skin and a slow growth ***,AA broilers had a relatively slow rise in blood glucose in response to oral glucose solution than the Silky chickens on 21 and 42 d(Pglucose transporter 2(GLUT2)in the liver of AA broilers(Pglucose and the response speed of AA broilers to oral glucose were increased on d 21(Pglucose concentrations after 3 weeks compensatory growth were improved by early feed restriction in AA *** restriction could also upregulate the mRNA level of pancreatic INS on d 21 and 42,as well as decrease the expressions of PCK1,glucose-6-phosphatase catalytic(G6PC),and GLUT2 in the liver on d 21(Pglucose homeostasis than AA broilers,and feed restriction could improve the fasting blood glucose and the response to oral glucose of AA broilers.

关键词： Silky chicken AA broiler Feed restriction glucose tolerance Pancreas

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Mitochondrial protein IF1 is a potential regulator of glucagon-like peptide(GLP-1) secretion function of the mouse intestine

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1568-1577页

作者： Ying Wang Jiaojiao Zhang Xinyu Cao Yaya Guan Shuang Shen Genshen Zhong Xiwen Xiong Yanhong Xu Xiaoying Zhang Hui Wang Jianping Ye Henan Key Laboratory of Immunology and Targeted Therapy Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory MedicineSchool of Laboratory MedicineXinxiang Medical UniversityXinxiang 453003China Shanghai Diabetes Institute Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 201306China School of Forensic Medicine Xinxiang Medical UniversityXinxiang 453003China Central Laboratory Shanghai Sixth People's Hospital East CampusShanghai Jiao Tong UniversityShanghai 201306China

IF1(ATPIF1) is a nuclear DNA-encoded mitochondrial protein whose activity is inhibition of the F1Fo-ATP synthase to control ATP ***1 activity remains unknown in the regulation of GLP-1 *** this study,IF1 was examined in the diet-induced obese mice using the gene knockout(If1-KO) *** mice gained more body weight on a high fat diet without a change in food *** tolerance was impaired,but the oral glucose tolerance was improved through an increase in GLP-1 *** KO mice exhibited an improved intestine structure,mitochondrial superstructure,enhanced mitophagy,reduced apoptosis and decreased adenine nucleotide translocase 2(ANT2) protein in the intestinal epithelial cells together with preserved gut *** data suggest that GLP-1 secretion was enhanced in the obese If1-KO mice to preserve glucose tolerance through a signaling pathway of ANT2/mitochondria/L-cells/GLP-1/***1 is a potential mitochondrial target for induction of GLP-1 secretion in L-cells.

关键词： GLP-1 ATPIF1 ANT2 L-cells Mitophagy Microbiota glucose tolerance Insulin resistance

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Evaluation of hypoglycemic and hypolipidemic activities of aqueous extract of Cistus ladaniferus in streptozotocin-induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2016年第12期6卷 1044-1049页

作者： Mohamed El Kabbaoui Alae Chda Ouarda Azdad Najlae Mejrhit Lotfi Aarab Rachid Bencheikh Abdelali Tazi Laboratory of Bioactive Molecules Faculty of Sciences and TechniquesSidi Mohamed Ben Abdellah University(USMBA)

Objective:To evaluate the effect of aqueous leaf extract of Cistus ladaniferus(***) on glycemic and lipidemic status in diabetic ***:Overnight fasted rats were injected intraperitoneally with streptozotocin(45 mg/kg) to induce experimental *** aqueous extract of the leaves of *** was administered orally at the dose of 500 mg/kg body weight to diabetic rats for a period of 28 *** effect,body weight,oral glucose tolerance,change in lipid parameters,urea,creatinine,aspartate aminotransferase and alanine aminotransferase levels of diabetic rats treated with aqueous extract were evaluated in experimental ***:Administration of 500 mg/kg of *** extract to diabetic rats for 28 days resulted in a significant reduction in the levels of blood glucose,alanine aminotransferase,aspartate aminotransferase,urea and ***,the extract of *** improved glucose tolerance in diabetic rats,and its antidiabetic effect was similar to the one obtained with *** hypolipidemic effect was demonstrated by an important decrease in plasma total cholesterol,triglycerides and low density lipoprotein-cholesterol ***:It is concluded that *** leaf extract showed an antidiabetic activity in experimental diabetes which was similar to the one obtained with glibenclamide.

关键词： Cistus ladaniferus Diabetes mellitus Streptozotocin Antidiabetic activity Hypolipidemic activity glucose tolerance

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