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A Potential Role for GLUT4 in Predicting Sepsis in Critically Ill Children

Open Journal of Internal Medicine 2024年第1期14卷 1-15页

作者： Yanna Zhou Guangming Liu Xiaohui Wu Aidi Kuang Cuiping Zhu Qiuyan Peng Department of Pediatric Emergency Medicine Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou China

Background: This study investigated serum glucose transporter (GLUT) 4 levels and examined the relationship between serum GLUT4 levels and sepsis in critically ill children. Methods: This was a retrospective study of 77 critically ill children and 33 non-diabetic healthy children (controls) who were admitted between 07/2015 and 05/2016. Patient data, clinical information, and blood samples were collected on admission, alongside a large number of laboratory parameters that were routinely assessed. Critically ill patients were divided into sepsis and non-sepsis/systemic inflammatory response syndrome (SIRS). Serum GLUT4 was measured using western blotting and enzyme-linked immunosorbent assays. Insulin resistance indexes, clinical data, laboratory parameters, and inflammatory cytokines were assessed. Results: GLUT4 serum levels were higher in critically ill children than in healthy children (90.5 vs. 30.3 μg/L, P 0.05). Compared to healthy children, hyperglycemic patients (n = 48) had elevated GLUT4 serum levels (30.3 vs. 103.7 g/L, P Conclusions: GLUT4 serum levels might be significantly increased in critically ill children compared with healthy children, particularly those in septic shock. Serum GLUT4 could predict disease severity.

关键词： Children Critical Illness glucose transporter type 4 Hyperglycemia Insulin Resistance

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Effects of a fermented buckwheat flower and leaf extract on the blood glucose and lipid profile of type 2 diabetic db/db mice

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Journal of Traditional Chinese Medicine 2020年第2期40卷 197-203页

作者： Wang Jianxing Yu Xiaohan Jiang Yan Wang Yan Li Ying Han Shuying North China University of Science and Technology Jitang CollegeTangshan 063000China North China University of Science and Technology Clinical Medical CollegeTangshan 063000China North China University of Science and Technology Basic Medical CollegeTangshan 063000China Hebei Key Laboratory on Chronic Diseases Tangshan 063000China Tangshan Basic Clinical Research Key Laboratory on Chronic Diseases Tangshan 063000China

OBJECTIVE: To determine the efficacy of a fermented buckwheat flower and leaf extract(EFBFL) for the reduction of blood glucose and lipid dysregulation in spontaneously obese type 2 diabetic db/db mice, and to explore the possible mechanisms ***: Forty 9-week-old male db/db mice were randomly allocated to a high-dose EFBFL group(EFBFL-H), a low-dose EFBFL group(EFBFL-L),a metformin hydrochloride positive control group(MEG), and a db/db control group(MG), and there was also a db/m negative control group(NCG)(n =10). Oral glucose tolerance tests(OGTT) were performed after 7 weeks of treatment. At the end of 8 weeks of treatment, random blood glucose(RBG),glycosylated hemoglobin(Hb Alc), fasting plasma glucose(FPG), fasting serum insulin(FINS), triglyceride(TG), serum total cholesterol(TC), free fatty acids(FFA), high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol(LDL-c) were measured, the homeostasis model assessment-insulin resistance(HOMA-IR) was calculated. Immunohistochemistry and western blotting measured the expression of glucose transporter4(GLUT4) and peroxisome proliferator-activated receptor γ(PPAR-γ) by in skeletal ***: The MG mice had a significantly increased in RBG, Hb Alc, the HOMA-IR level, the serum of TG, TC, LDL-c, but a decreased in glucose tolerance and the protein expression of GLUT4 and PPAR-γ compared with the NCG. Compared with the MG, EFBFL groups significantly decreased RBG, Hb Alc, and the HOMA-IR level, increased glucose tolerance. Meanwhile EFBFL groups reduced the serum TG, TC, and LDL-c in a dose-dependent manner. In addition, EFBFL increased the protein expression of GLUT4 and PPAR-γ in the skeletal muscle of db/db *** was significant difference between the MG group and EFBFL ***: These findings suggest that EFBFL has anti-diabetic effects in db/db mice, ameliorating glucose intolerance, lipid dysregulation, and insulin resistance.

关键词： Eriogonum Diabetes mellitus,type 2 Muscle,skeletal glucose transporter type 4 PPAR gamma

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Hyperbaric oxygen ameliorates insulin sensitivity mobilizing GLUT4 membrane translocation in skeletal muscle and energy metabolism in brown adipose in T2DM mice

Hyperbaric oxygen ameliorates insulin sensitivity mobilizing...

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2019中国生理学会学术年会暨张锡钧基金第十五届全国青年优秀生理学学术论文交流会及第十三届全国青年生理学工作者学术会议

作者：刘媛 Yanrun Li Kaizhen Su Limin Song Manwen Li Qian Lin Jing Dong Department of Special Medicine Basic Medical CollegeQingdao University Medical College Qingdao University Department of Physiology Medical CollegeQingdao University

This study aimed to investgate whether hyperbaric oxygen(HBO) could ameliorate insulin sensitivity, promoting glucose transporter type 4(GLUT4) membrane translocation in muscle and energy metabolism in brown adipose tissue from a streptozocin(STZ)-induced type 2 diabetes mellitus(T2 DM) mice *** C57 BL/6 J mice were rendered three times low-dose streptozocin(60 mg/kg, i.p.) fed with high-fat diets(HFD) to build T2 DM *** was conducted daily by giving 100% oxygen at 2.0 atmosphere absolute(ATA) for 1 hour for a ***, HBO significantly reduced blood glucose and attenuated insulin resistance in T2 *** modulated the food intake by influencing the activity of neuropeptide Y(NPY)-positive neurons in Arcuate nucleus(Arc).Immunofluorescence showed that GLUT4 membrane translocation is increased induced by HBO in T2 DM but not in HFD mice, as well as phosphorylated Akt(p-Akt)level measured by western blot ***, morphology staining of BAT and increasing uncoupling protein 1(UCP1) expression show the promoting metabolism after HBO *** conclusion, HBO ameliorate insulin sensitivity to enhance Akt signaling pathway, promoting GLUT4 membrane translocation in muscle and energy metabolism in BAT in T2 DM mice.

关键词： Hyperbaric oxygen type 2 diabetes mellitus insulin sensitivity glucose transporter type 4 UCP1

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