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Fluorescent probes for glucolipid metabolism of bacterial cell wall

Green Chemical Engineering 2023年第4期4卷 417-426页

作者： Yurou Huang Xiaoxie Ma Caimin Gao Yuan Xie Mingqiang Qiu Jun Yin Key Laboratory of Pesticide and Chemical Biology Ministry of EducationHubei International Scientific and Technological Cooperation Base of Pesticide and Green SynthesisInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan430079China Guangdong Provincial Key Laboratory of Radioactive and Rare Resource Utilization Shaoguan512026China

Cell wall is a basic component of bacteria that promotes bacteria to adapt the complicated environment as well as play an essential role in antimicrobial resistance.The structure of bacterial cell wall is remarkably rich,and some complex components,such as peptidoglycan,lipopolysaccharide,and peptidoglycan-arabinogalactan et al.,can only be found in bacteria.Furthermore,the biosynthesis and transfer of these glycolipids are indispensable for bacteria during cell elongation.And the process of biosynthesis and transfer are generally associated with metabolism and sophisticated enzyme mechanisms.However,how the metabolic process takes place,what role enzymes play in this process and how they function have been major concerns for scientists in this field.Numerous significant progresses on fluorescent probes and biological imaging bring opportunity for the studying of metabolism and enzyme mechanisms recently due to its non-invasive and high sensitivity.In this review,we focused on metabolic fluorescent probes for the detection of glycolipids in bacterial cell wall and highlighted the involving mechanisms and biological application.

关键词： Fluorescent probes Bacteria Cell wall glucolipid metabolism

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Activating transcription factor 3,glucolipid metabolism,and metabolic diseases

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Journal of Molecular Cell Biology 2022年第10期14卷 1-10页

作者： Shuwei Hu Xiaojie Zhao Rui Li Chencheng Hu Huĳuan Wu Jing Li Yanqiao Zhang Yanyong Xu Department of Integrative Medical Sciences Northeast Ohio Medical UniversityRootstownOH 44272USA Department of Pathology School of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Endocrinology Beĳing Chao-yang HospitalCapital Medical UniversityBeĳing 100020China Key Laboratory of metabolism and Molecular Medicine of the Ministry of Education Department of Pathology of School of Basic Medical SciencesFudan UniversityShanghai 200032China Frontier Innovation Center School of Basic Medical SciencesFudan UniversityShanghai 200032China

Lipids and glucose exert many essential physiological functions,such as providing raw materials or energy for cellular biosynthesis,regulating cell signal transduction,and maintaining a constant body temperature.Dysregulation of lipid and glucose metabolism can lead to glucolipid metabolic disorders linked to various metabolic diseases,such as obesity,diabetes,and cardiovascular disease.Therefore,intervention in glucolipid metabolism is a key therapeutic strategy for the treatment of metabolic diseases.Activating transcription factor 3(ATF3)is a transcription factor that acts as a hub of the cellular adaptive-response network and plays a pivotal role in the regulation of inflammation,apoptosis,DNA repair,and oncogenesis.Emerging evidence has illustrated the vital roles of ATF3 in glucolipid metabolism.ATF3 inhibits intestinal lipid absorption,enhances hepatic triglyceride hydrolysis and fatty acid oxidation,promotes macrophage reverse cholesterol transport,and attenuates the progression of western diet-induced nonalcoholic fatty liver disease and atherosclerosis.In addition to its role in lipid metabolism,ATF3 has also been identified as an important regulator of glucose metabolism.Here,we summarize the recent advances in the understanding of ATF3,mainly focusing on its role in glucose and lipid metabolism and potential therapeutic implications.

关键词： ATF3 glucolipid metabolism metabolic organ metabolic diseases

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Sex-dependent obesogenic effect of tetracycline on Drosophila melanogaster deteriorated by dysrhythmia

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Journal of Environmental Sciences 2023年第2期124卷 472-480页

作者： Xueping Guo Zhenyang Yu Daqiang Yin State Key Laboratory of Pollution Control and Resource Reuse Key Laboratory of Yangtze River Water EnvironmentMinistry of EducationCollege of Environmental Science and EngineeringTongji UniversityShanghai 200092China Jiaxing Tongji Institute for Environment Jiaxing 3014051China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

Antibiotics have been identified as obesogens contributing to the prevalence of obesity.Moreover,their environmental toxicity shows sex dependence,which might also explain the sex-dependent obesity observed.Yet,the direct evidence for such a connection and the underlying mechanisms remain to be explored.In this study,the effects of tetracycline,which is a representative antibiotic found in both environmental and food samples,on Drosophila melanogaster were studied with consideration of both sex and circadian rhythms(represented by the eclosion rhythm).Results showed that in morning-eclosed adults,tetracycline significantly stimulated the body weight of females(AM females)at 0.1,1.0,10.0 and 100.0μg/L,while tetracycline only stimulated the body weight of males(AM males)at 1.0μg/L.In the afternoon-eclosed adults,tetracycline significantly stimulated the body weight of females(PM females)at 0.1,1.0 and 100.0μg/L,while it showed more significant stimulation in males(PM males)at all concentrations.Notably,the stimulation levels were the greatest in PMmales among all the adults.The results showed the clear sex dependence of the obesogenic effects,which was diminished by dysrhythmia.Further biochemical assays and clustering analysis suggested that the sex-and rhythm-dependent obesogenic effects resulted from the bias toward lipogenesis against lipolysis.Moreover,theywere closely related to the preference for the energy storage forms of lactate and glucose and also to the presence of excessive insulin,with the involvement of glucolipid metabolism.Such relationships indicated potential bridges between the obesogenic effects of pollutants and other diseases,e.g.,cancer and diabetes.

关键词： Obesogenic effect Tetracycline Sex Circadian rhythm glucolipid metabolism

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Intrauterine growth retardation affects liver bile acid metabolism in growing pigs:effects associated with the changes of colonic bile acid derivatives

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Journal of Animal Science and Biotechnology 2023年第2期14卷 711-728页

作者： Yang Liu MdAbul Kalam Azad Wanghong Zhang Liang Xiong Francois Blachier Zugong Yu Xiangfeng Kong Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro‑Ecological Processes in Subtropical RegionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125HunanChina College of Veterinary Medicine Nanjing Agricultural UniversityNanjing 210095JiangsuChina UMR PNCA Universite Paris-SaclayINRAE75005 AgroParisTechParisFrance.

Background:Intrauterine growth retardation(IUGR)is associated with severely impaired nutrient metabolism and intestinal development of pigs.Our previous study found that IUGR altered intestinal microbiota and metabolites in the colon.However,the consequences of IUGR on bile acid metabolism in pigs remained unclear.The present study aimed to investigate the bile acid metabolism in the liver and the profile of bile acid derivatives in the colon of grow-ing pigs with IUGR using bile acid targeted metabolomics.Furthermore,we determined correlations between colonic microbiota composition and metabolites of IUGR and normal birth weight(NBW)pigs at different growth stages that were 7,21,and 28-day-old,and the average body weight(BW)of 25,50,and 100 kg of the NBW pigs.Results:The results showed that the plasma total bile acid concentration was higher(Pmetabolism(ATGL,HSL,and PC)were down-regulated(Pglucolipid metabolism in growing pigs,especially at the 25 kg BW stage,these effects being paralleled

关键词： Bile acid metabolism glucolipid metabolism Intestinal microbiota Intrauterine growth retardation Pigs

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Study on the Correlation Between SFRP-5 Expression Level, Insulin Resistance, and Glycolipid metabolism in Gestational Diabetes Mellitus

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Journal of Clinical and Nursing Research 2023年第2期7卷 53-58页

作者： Bei Wang Chenyuan Cao Rui Li Yan An Fang Wang Yuxiang Huang Jinjin Qin Affiliated Hospital of Hebei University Baoding 071000China

Objective:To investigate the correlation between serum secretory frizzled-related protein 5(SFRP-5)expression levels and insulin resistance and glucolipid metabolism in patients with gestational diabetes mellitus(GDM).Methods:Baseline data were collected from 58 patients with GDM and 51 healthy controls who were admitted Affiliated Hospital of Hebei University from May 2020 to June 2022.sSTRA5 concentrations in peripheral blood of pregnant women were measured,and SFRP-5 levels in patients with different GDM types and normal controls were analyzed by logistic regression models.Results:The levels of triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),fasting blood glucose(FBG),fasting insulin(FINS),hemoglobin A1c(HbA1c),and homeostasis model assessment-estimated insulin resistance(HOMA-IR)were higher in the observation group than in the control group,with statistically significant differences(Pmetabolism and inflammatory response.

关键词： Gestational diabetes mellitus Secretory frizzled-related protein 5 Insulin resistance glucolipid metabolism

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