检索结果-南通市图书馆

Co-Inhibitors of Second Signal of Lymphocyte Response in Human Renal Transplants: PD-L2, GITR, and ILT-2/3/5 Positive Cells from Aspiration Biopsies Associate with Acute Rejection-Freedom

引用

Open Journal of Nephrology 2021年第1期11卷 58-77页

作者： Paula D. P. Xavier José Gerardo G. Oliveira Instituto Português do Sangue e da Transplantaç ã o área Transplanta&#231 ã o Rua do Bolama Porto Portugal GCCT Centro Hospitalar Universitário S. Jo&#227 o Alameda Hernani Monteiro Porto Portugal CINTESIS Faculdade de Medicina da Universidade do Porto Alameda Hernani Monteiro Porto Portugal

Following organ transplantation, the outcome of the encounter between an APC and a T lymphocyte is strongly dependent on the presence of costimulatory and co-inhibitory molecules, the former associated with allograft rejection and the latter with allograft acceptance. We evaluated the expression of PD-L2, GITR, ILT-2/3/5, and ILT-4 on graft-infiltrating cells procured by Fnab from human KTx under different immunosuppressive regimens. Methods: Fnab biopsies were performed on days 7 or 14 - 30 in stable KTx and on the day of acute rejection diagnosis. Cytopreparations were studied by the enzymatic avidin biotin complex staining. Results: Acute rejection group showed a significant down-regulated expression of PD-L2, GITR, and ILT-2/3/5 as compared to stable group, while for ILT-4 we did not find significant difference. Anti-IL2αR and rapamicyn treatment trend to down-regulate ILT-4 expression, although meaningless. A significantly positive correlation was observed between PD-L2 and GITR expression in Fnab. The PPV for acute rejection diagnosis for both PD-L2 and GITR was clearly above 0.8. Conclusions: Our findings point to an early entrance of cells expressing PD-L2, GITR and ILT-2/3/5 inside human KTx who are going to remain rejection-free. Both PD-L2 and GITR shared a high ability to rule-in and rule-out acute rejection.

关键词： Antigen-Presenting Cell Fine-Needle Aspiration Biopsy glucocorticoid-induced tumor necrosis factor receptor Immunoglobulin-Like Transcript Kidney Transplant Programmed Death-Ligand 2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The regulation of Treg cells and GITR by dexamethasone in collageninduced arthritis in mice

The regulation of Treg cells and GITR by dexamethasone in co...

引用

2015浙江省检验医学学术年会

作者：张莉莉 Juping Du Jiaxi Chen Jianfeng Shi Shiyong Chen Bo Shen Department of Clinical Laboratory Taizhou Hospital of Zhejiang ProvinceAffiliated Hospital of Wenzhou Medical University Department of Clinical Laboratory Taizhou Hospital of Zhejiang Province Department of Clinical LaboratoryTaizhou Hospital of Zhejiang Province

In this study,we investigated the effects of dexamethasone(DEX) on the expansion of regulatory T(Treg)cells and glucocorticoid-induced tumor necrosis factor receptor(GITR),the down regulation of CD4+CD25-T cells,the up regulation of CD4+CD25+ T cells and the control of the severity of collagen-induced arthritis(CIA).CIA-induced mice were injected intraperitoneally with DEX once a day for seven ***4+CD25-T cells,CD4+CD25+T cells,Treg cells and GITR,a functional surface molecule of Treg cells were analysed by flow *** severity was evaluated by arthritic score,synovial histopathology and radiography of *** of DEX increased the proportion of Treg cells and the GITR fluorescence intensity among peripheral ***,up regulation of CD4+CD25+T cells and down regulation of CD4+CD25-T cells were *** markedly reduced CIA-induced arthritic score,*** regulation of Treg cells and GITR by DEX can participate in the immune regulation process of ***,it may provide a scientific basis for the treatment of RA immune mechanism.

关键词： dexamethasone collagen-induced arthritis glucocorticoid-induced tumor necrosis factor receptor regulatory T cell

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：