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全麻联合硬膜外麻醉对胃癌根治术患者炎症、应激反应的影响

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分子诊断与治疗杂志 2024年第5期16卷 791-795页

作者：文静胡德俊王雪涵金堂县第一人民医院麻醉科四川成都610400

目的分析全麻联合硬膜外麻醉对胃癌根治术患者炎症、应激反应的影响。方法选取2020年7月至2023年5月金堂县第一人民医院收治的胃癌根治术患者108例,根据麻醉方式分为对照组53例(全麻)、观察组(全麻联合硬膜外麻醉)55例。比较两组麻醉相... 详细信息

目的分析全麻联合硬膜外麻醉对胃癌根治术患者炎症、应激反应的影响。方法选取2020年7月至2023年5月金堂县第一人民医院收治的胃癌根治术患者108例,根据麻醉方式分为对照组53例(全麻)、观察组(全麻联合硬膜外麻醉)55例。比较两组麻醉相关指标、疼痛情况、生命体征变化、炎症、应激反应及不良反应。结果观察组拔管时长、术后醒来时长均短于对照组,差异有统计学意义(P0.05)。观察组术后1 h、4 h、8 h、12 h及24 h VAS评分均低于对照组,差异有统计学意义(P0.05);T_(1)、T_(2)观察组MAP、HR均低于对照组,差异有统计学意义(Pglu及COR水平比较,差异无统计学意义(P>0.05);T_(1)、T_(2)比较,观察组TNF-α、IL-6、glu及COR水平均低于对照组,差异有统计学意义(Pglu及COR水平,可改善炎症、应激反应,且安全性良好。

关键词：全麻硬膜外麻醉胃癌根治术 TNF-α glu COR

glutamic acid supplementation recovers the reduced performance of weanling pigs fed reduced crude protein diets

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Animal Nutrition 2022年第1期8卷 249-255页

作者： Santi D.Upadhaya Sang Seon Lee Young Hwa Kim Zhenlong Wu In Ho Kim Department of Animal Resource and Science Dankook UniversityNo.29 AnseodongCheonanChoongnam 31116South Korea National Institute of Animal Science 114 Sinbangro-1 GilSeongjwan-eupSeobuk-guCheonan-si31000South Korea State Key Laboratory of Animal Nutrition Department of Animal Nutrition and Feed ScienceChina Agricultural UniversityBeijing 100193China

This study was conducted to evaluate the supplementation of glutamic acid(glu)to reduced protein diets on the performance of weanling pigs.One hundred and eighty crossbred weanling pigs([YorkshireLandrace]Duroc,21 d old)having similar body weight(BW)of 6.45 kg were randomly allotted to 1 of 6 dietary treatments(5 pigs per pen[2 barrows and 3 gilts];6 pens per treatment)based on BW and sex during a 6-week trial.Dietary treatments consisted of positive control(PC)diet formulated to have 226.9,205.6,and 188.8 g crude protein(CP)during phases 1,2,and 3,respectively,and negative control(NC)diets with 20 g CP reduction from PC diets and addition of glu with increasing levels,resulting in the calculated Lys-to-glu ratios of 1:2.25,1:2.30.1:2.35,1:2.40,and 1:2.45,designated as NC,NC1,NC2,NC3,and NC4,respectively.The BW of pigs receiving PC diet was higher(Pglu linearly increased(Pglu.In conclusion,supplementing the reduced protein diet with glu enhanced the growth performance in weanling pigs suggesting that supplementation of glu can compensate the reduction of 2%CP in the basal diets.

关键词： glu Growth performance Reduced protein diet Weanling pig

Heat capacity and thermodynamical properties of the crystal of [RE_2(glu)_2(H_2O)_8](ClO_4)_4·H_2O (RE = Nd, Eu, Dy)

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Science China Chemistry 2009年第7期52卷 862-867页

作者： WU XinMin1, LI Wei1, TAN ZhiCheng2 & QU SongSheng3 1 Department of Chemical Engineering, Beijing Institute of Petro-chemical Technology, Beijing 102617, China 2 Thermochemistry Laboratory, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China 3 College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, China Department of Chemical Engineering Beijing Institute of Petro-chemical Technology Beijing China Thermochemistry Laboratory Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China College of Chemistry and Molecular Science Wuhan University Wuhan China

Thermodynamical data of rare earth complexes with amino acid are important for engineering chemistry and fundamental chemistry. However, they have rarely been reported. In this work, a series of crystalline complexes of rare earth perchlorate coordinated with glutamic acid have been synthesized in water medium, and their thermodynamical data, including the heat capacity in low temperature range and the standard enthalpy of formation, were determined. These complexes were identified to be [RE2(glu)2(H2O)8](ClO4)4·H2O (RE = Nd, Eu, Dy) by using thermogravimetric analysis (TG), differential thermal analysis (DTA), and chemical and elementary analyses. Their purity has been determined. No melting points were observed for all the three complexes. The heat capacity of the complexes was measured by an adiabatic calorimeter from 79 to 370 K. Abnormal heat capacity values were detected for two of the complexes and the decomposition range of one complex was found. The temperature, enthalpy change and entropy change of the decomposition processes of the three complexes were calculated. The polynomial equations of heat capacity in the experimental temperature range have been obtained by least squares fitting. The standard enthalpy of formation was determined by an isoperibol reaction calorimeter at 298.15 K.

关键词： complex of rare earth, [RE2(glu)2(H2O)8](ClO4)4·H2O (RE = Nd, Eu, Dy glu = glutamic acid), low-temperature heat capacity, standard enthalpy of formation

Synthesis of 2,2-Bis-C-functionalized Chain glucosid-3-ketals

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Chinese Journal of Chemistry 2012年第1期30卷 195-198页

作者：张福义刘虹盛英明刘宏民 Chemistry Department The Key Lab of Chemical Biology and Organic Chemistry of Henan ProvinceZhengzhou UniversityZhengzhouHenan 450052China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhouHenan 450001China

新奇 2,2-bis-C-functionalized 链 glucosid-3-uloses 在 ketal 形式被综合了。合成通过一壶 multistep 反应是相当方便的，没有昂贵的试剂被包含。产品经由 autoxidation-Michael 增加机制被形成，他们的结构被 X 光检查结晶的分析描... 详细信息

新奇 2,2-bis-C-functionalized 链 glucosid-3-uloses 在 ketal 形式被综合了。合成通过一壶 multistep 反应是相当方便的，没有昂贵的试剂被包含。产品经由 autoxidation-Michael 增加机制被形成，他们的结构被 X 光检查结晶的分析描绘。他们的水晶 stuctures 是由分子间的氢契约和双海滨的 stablilized 超分子的叠被观察。

关键词：合成双链 X射线晶体分析迈克尔加成分子间氢键分子堆积酮 glu

针刺三阴交、神门、内关对失眠大鼠下丘脑5-HT含量及glu/GABA比值影响机制的探究

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中华中医药学刊 2022年第3期40卷 65-68页

作者：刘丽莎董宝强刘旭来于本性苏妆王淑娟白增华陈怡然张妤金毅轩马铁明辽宁中医药大学辽宁沈阳110847

目的以西药地西泮作为对照,探求针刺三阴交、神门、内关对失眠SD大鼠下丘脑5羟色胺(5-HT)、谷氨酸(glu)、γ-氨基丁酸(GABA)递质含量及glu/GABA比值影响的研究;以期探索针刺治疗失眠机制的作用及有效性,为今后治疗失眠提供更多科学依据... 详细信息

目的以西药地西泮作为对照,探求针刺三阴交、神门、内关对失眠SD大鼠下丘脑5羟色胺(5-HT)、谷氨酸(glu)、γ-氨基丁酸(GABA)递质含量及glu/GABA比值影响的研究;以期探索针刺治疗失眠机制的作用及有效性,为今后治疗失眠提供更多科学依据。方法48只雄性SD大鼠,随机分为空白组、模型组、西药组(地西泮)、针刺组,每组12只。采用对氯苯丙氨酸诱导构建失眠大鼠模型。针刺组施以电针三阴交、神门、内关,频率60 Hz,强度1 mA,10 min/次,西药组施以地西泮灌胃治疗(0.92 mg/kg),空白组、模型组不予任何治疗,仅予相同时间的捉抓刺激。干预6 d后,采取酶联免疫法测量5-HT、GABA含量,葡萄糖测定法测量glu含量。结果实验结果显示,针刺组与西药组对失眠均有疗效;模型组与空白组相比,大鼠下丘脑5-HT含量明显减少(Pglu增长显著;GABA含量明显减少;相比模型组,针刺组下丘脑5-HT、GABA含量显著增多,glu含量减少,呈显著差异(Pglu水平,使各指标切近于正常水平,差异有统计学意义(Pglu/GABA比值明显降低,差异存在统计学意义(Pglu/GABA-Gln代谢通路,提升失眠大鼠下丘脑5-HT、GABA的水平,并降低glu水平来发挥治疗作用,揭示针刺是通过升高抑制性神经元水平来调节兴奋/抑制的动态平衡,从而优化睡眠结构。

关键词：失眠针刺 5-HT glu GABA glu/GABA比值

寒地城市老年人群睡眠质量调查及电针对寒冷因素下失眠大鼠行为学及血清glu、GABA水平影响

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寒地城市老年人群睡眠质量调查及电针对寒冷因素下失眠大鼠行为学...

作者：武文慧黑龙江中医药大学

学位级别：硕士

目的:1.通过横断面调查,研究一般因素及中医体质类型与寒地城市老年人群睡眠质量的关系,为改善寒地城市老年人群的睡眠质量提供依据。2.研究寒冷因素对大鼠睡眠的影响。3.探讨电针刺激“照海”、“申脉”穴对寒冷因素下失眠大鼠睡眠的影... 详细信息

目的:1.通过横断面调查,研究一般因素及中医体质类型与寒地城市老年人群睡眠质量的关系,为改善寒地城市老年人群的睡眠质量提供依据。2.研究寒冷因素对大鼠睡眠的影响。3.探讨电针刺激“照海”、“申脉”穴对寒冷因素下失眠大鼠睡眠的影响,为针刺治疗寒地失眠提供更多的科学依据。方法:1.流行病学调查本研究采用整群随机抽样的方法,于2022年9月～2023年2月随机抽取哈尔滨市4个社区及3家养老机构550名60岁以上的老年人作为研究对象,利用一般资料调查表、匹兹堡睡眠指数量表及中医体质评定量表进行横断面调查。2.实验研究一选取SPF级Wistar雄性大鼠40只,随机分为4组:室温组、寒冷组、失眠模型组、寒冷失眠组,每组10只。室温组、失眠模型组大鼠在动物房正常饲养,寒冷组、寒冷失眠组大鼠在-10℃的寒冷环境中冷暴露1.5h/d,其余时间室温饲养。15d后失眠模型组、寒冷失眠组大鼠连续3天腹腔注射PCPA混悬液(350mg/kg)以建立失眠模型,室温组、寒冷组大鼠注射等体积生理盐水。观察并记录各组大鼠一般状态,行为学差异,下丘脑病理变化及血清5-HT神经递含量。3.实验研究二采用“PCPA复合低温冷冻法”建立寒冷因素下失眠模型,将造模成功的大鼠随机分为模型组、针刺治疗组、电针治疗组,另设空白组做对照,每组10只。在实验治疗时,4组大鼠均选取相同的固定方式,在此基础上,针刺治疗组和电针治疗组选取双侧照海、申脉作为针刺穴位,电针治疗组刺激参数选择2Hz疏波,电流强度调节至针柄微微颤动,每次治疗20min,日1次,连续治疗7d。观察并记录各组大鼠一般状态,行为学差异及血清glu、GABA神经递质的含量。结果:1.流行病学调查共计完成516例寒地城市老年人群的调查,平均年龄(71.35±8.23)岁,PSQI>7有243例,睡眠障碍患病率47.09%。通过χ2检验单因素分析比较睡眠障碍与年龄、是否吸烟构成比差异无统计学意义(P>0.05),性别、受教育程度、饮酒、慢性病及季节构成比差异具有统计学意义(P7的老年人群体质类型分布前三位分别是气虚质、阳虚质、阴虚质,PSQI≤7的老年人群体质类型分布前三位分别是平和质、血瘀质、湿热质。通过χ2检验单因素分析比较睡眠障碍与痰湿质、湿热质、气郁质、血瘀质、特禀质构成比差异无统计学意义(P>0.05),平和质、气虚质、阳虚质和阴虚质构成比差异具有统计学意义(P0.05);实验后寒冷组、失眠模型组大鼠较室温组体重均减少(Pglu含量增加(Pglu含量减少(Pglu含量减少(P<0.05),GABA含量增加(P<0.05)。结论:1.寒地城市老年人群睡眠障碍患病率47.09%,低学历、慢性病种类多、饮酒、季节是睡眠障碍的危险因素,阳虚质、气虚质、阴虚质是睡眠障碍的易感体质。2.低温环境可能通过降低血清5-HT、影响下丘脑组织病理形态学对大鼠睡眠产生影响。3.针刺、电针均可改

关键词：流行病学调查电针寒冷失眠大鼠 glu GABA

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HCN通道在焦虑中作用的研究进展

中国细胞生物学学报 2022年第5期44卷 956-963页

作者：王清赵航吴凡舒渝茜章帆鲁娇何治三峡大学国家中医药管理局中药药理科研三级实验室宜昌443002 三峡大学医学院宜昌443002

超极化激活环核苷酸门控(hyperpolarization-activated cyclic nucleotide-gated,HCN)通道具有重要的生理功能,尤其是在静息膜电位、树突整合、神经元起搏和动作电位阈值的建立等方面作用明显。研究发现,HCN通道的失调可能会引起焦虑,... 详细信息

超极化激活环核苷酸门控(hyperpolarization-activated cyclic nucleotide-gated,HCN)通道具有重要的生理功能,尤其是在静息膜电位、树突整合、神经元起搏和动作电位阈值的建立等方面作用明显。研究发现,HCN通道的失调可能会引起焦虑,该通道介导焦虑作用的机制可能受脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)/哺乳动物雷帕霉素靶点(mammalian target of rapamycin,mTOR)、谷氨酸(glutamate,glu)、γ-氨基丁酸(γ-aminobutyric acid,GABA)、单胺类神经递质、突触可塑性等的调节。现就HCN通道的结构、分布、调节及介导焦虑作用可能的机制进行综述,以期为焦虑症的预防和治疗提供药物治疗靶点。

关键词：焦虑 HCN通道 BDNF/mTOR glu GABA 单胺类神经递质突触可塑性

Effects of Peiyuan Tongnao Capsule on Working Memory and the Expression of glutamic Acid and Receptor in Hippocampal Area in Rats with Cerebral Ischemia

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World Journal of Traditional Chinese Medicine 2019年第1期5卷 36-41页

作者： Jing Bai Ying Gao Yong-Hong Gao Wang Li Department of Neurology Dongzhimen Hospital Beijing University of Chinese Medicine Institute of Encephalopathy Dongzhimen Hospital Beijing University of Chinese Medicine

Objective: To explore the effects of Peiyuan Tongnao(PYTN) Capsule on working memory, the content of glutamic acid, and the expression of NMDA receptor 2 B(NR2 B) in rats with cerebral ischemia. Materials and Methods: 52 Sprague-Dawley rats were randomly divided into sham group, model group, nimodipine group, and PYTN group. The bilateral common carotid artery occlusion(BCAO) was performed to establish rat model with cerebral ischemia in the model, nimodipine, and PYTN groups. Gastric lavage with some drug based on body weight conversion was performed daily for 4 weeks in the nimodipine and PYTN groups. The working memory of the rats was tested by Morris water maze. The expression of Nissl body in hippocampus tissue was observed by Nissl staining. The determination of glu content in hippocampus was detected by high-performance liquid chromatography. The expression level of NR2 B in hippocampus area was determined using Western blot. Results: Morris water maze test on working memory escape latency. In the model group, day 1 versus day 4, there was a statistical difference(P glu content in hippocampus of the sham group was significantly different from that of model group(P glu content in the PYTN group was significantly different from that of the model group(P glu and NMDAR2 B in hippocampus.

关键词： Cerebral ischemia glu NMDA receptor 2B. Peiyuan Tongnao capsule working memory

电引导治疗颞叶癫痫大鼠中电流强度与疗效的量效关系及其神经保护机制研究

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电引导治疗颞叶癫痫大鼠中电流强度与疗效的量效关系及其神经保护...

作者：张绍辉锦州医科大学

学位级别：硕士

目的探讨电引导治疗颞叶癫痫大鼠中电流强度与治疗效果的量效关系及其神经保护机制。方法将清洁级健康Sprague-Dawley(SD)大鼠(200-300g/只)随机分为对照组、高电阻引导组和低电阻引导组;在右侧海马CA1区置入引导电极,右侧海马CA3区置... 详细信息

目的探讨电引导治疗颞叶癫痫大鼠中电流强度与治疗效果的量效关系及其神经保护机制。方法将清洁级健康Sprague-Dawley(SD)大鼠(200-300g/只)随机分为对照组、高电阻引导组和低电阻引导组;在右侧海马CA1区置入引导电极,右侧海马CA3区置入脑电图电极;采用红藻氨酸建立颞叶癫痫模型;用引导电极对颞叶癫痫大鼠进行电引导治疗24 h或7 d后,视频脑电图监测观察SD大鼠的癫痫发作频率及脑电图癫痫样放电情况;Morris水迷宫测试大鼠的认知功能;使用FAST16mk III神经递质测定仪检测海马内谷氨酸(glutamate,glu)、γ-氨基丁酸(γ-aminobutyric acid,GABA)的含量;采用RT-PCR检测海马内高迁移率族蛋白1(high mobility group protein B1,HMGB-1)、Toll样受体4(Toll-like receptor 4,TLR-4)、白细胞介素1β(interleukin 1β,IL-1β)和白细胞介素1受体1(Interleukin 1 receptor1,IL-1R1)的m RNA水平;采用Western Blot检测海马内HMGB-1/TLR-4、IL-1β/IL-1R1蛋白的表达含量;采用免疫组化和免疫荧光观察海马组织的HMGB-1/TLR-4和IL-1β/IL-1R1蛋白的表达。结果红藻氨酸(Kainic acid,KA)诱导的颞叶癫痫(temporal lobe epilepsy,TLE)模型中,在注射红藻氨酸10～20 min后,开始出现咀嚼运动、行为呆滞、身体强直等表现,继而出现单侧或双侧前肢抽搐、湿狗样抖动、四肢不自主抽搐或痉挛,最终出现全身强直-痉挛发作,跌倒。对150只大鼠进行建模,有128只成功建立颞叶癫痫模型,其中2只在注射戊巴比妥钠后2 h内死亡,9只在癫痫发作后24h内死亡,11只未出现典型的癫痫发作。建模成功率85.33%,死亡率7.33%。2、颞叶癫痫SD大鼠的总癫痫发作频率,低电阻引导组glu/GABA含量比值,癫痫对照组和低电阻引导组在20～180 min时的glu/GABA比值存在显著差异,高电阻引导组和低电阻引导组在20～120 min时的glu/GABA比值也存在显著差异。4、RT-PCR实验,在电引导治疗24 h后,低电阻引导组(Pglu/GABA、HMGB1/TLR-4和IL-1β/IL-1R1可能参与了电引导治疗的抗癫痫机制。

关键词：颞叶癫痫电引导 glu HMGB-1 IL-1β