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glomerular filtration rate is Associated with Hemorrhagic Transformation in Acute Ischemic Stroke Patients without Thrombolytic Therapy

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Chinese Medical Journal 2018年第14期131卷 1639-1644页

作者： Ming-Su Liu Yan Liao Guang-Qin Li Department of Neurology First Affiliated Hospital of Chongqing Medical University Chongqing 400016 China Chongqing Key Laboratory of Neurobiology Chongqing 400016 China Department of Neurology Chengdu 363 Hospital of Southwest Medical University Chengdu Sichuan 610000 China

Background： Whether there is a relationship between glomerular filtration rate IGFR） and hcnlorrhagic transformation （HT） after acute ischemic stroke （A1S） is still under debate. The aim of our study was to determine whether the GFR level is a predictor of HT in AIS patients without thrombolytic therapy （TT）. Methods： Consecutive A IS patients without TT were included in this prospective study fiom January 2014 to December 2016 in the First Affiliated Hospital of Chongqiug Medical University. We divided them into two groups （HT and non-HT group） and meticulously collected baseline characteristics and laboratory and imaging data of interested individuals. Multivariate regression analysis was performed to assess the correlation between GFR and HT in stroke patients without TT. Results： Among 426 consecutive patients, 74 （17.3%） presented HT （mean age： 65 ± 12 years, number of male patients： 47） on the follow-up scans. In multivariate regression analysis, HT was significantly associated with low GFR （odds ratio [OR] = 3.708, confidence interval [CI] = 1.326-10.693, P = 0.013）, atrial fibrillation （AF; OR = 2.444, CI= 1.087-5.356, P = 0.027）, large cerebral inthrction （OR = 2.583, CI= 1.236-5.262, P= 0.010）, and hypoalbuminemia （HA OR = 4.814, CI= 1.054 22.153, P = 0.037） for AIS patients without TT. Conclusions： The present study strongly showed that lower GFR is an independently predictor of HT： in addition, large inlhrct volume, AF, and HA are also important risks of HT for AIS patients without TT, which offered a practical information that risk factors should be paid attention or eliminated to prevent HT for stroke patients though the level of evidence seems to be unstable.

关键词： glomerular filtration rate Hemorrhagic Transformation Nonthrombolytic Treatment: Stroke

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Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea

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Frontiers of Medicine 2019年第6期13卷 713-722页

作者： Seo Yeon Baik Hyunah Kim So Jung Yang Tong Min Kim Seung-Hwan Lee Jae Hyoung Cho Hyunyong Lee Hyeon Woo Yim Kun-Ho Yoon Hun-Sung Kim Department of Medical Informatics College of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea College of Pharmacy Sookmyung Women’s UniversitySeoul 04310Republic of Korea Division of Endocrinology and Metabolism Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Clinical Research Coordinating Center Catholic Medical CenterThe Catholic University of KoreaSeoul 06591Republic of Korea Department of Preventive Medicine College of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Few long-term follow-up studies have compared the changes in renal function according to the type of statin used in *** compared the long-term effects of statin intensity and type on the changes in the glomerular filtration rate(GFR).We extracted data of patients who took statin for the first *** analyzed whether or not different statins affect the changes in GFR at 3 months after baseline and 4 years *** included 3678 patients and analyzed the changes in *** GFR decreased by 3.2%±0.4%on average 4 years after the first statin prescription,indicating statistically significant deterioration(from 83.5±0.4 mL/min/1.73 m2 to 79.9±0.4 mL/min/1.73 m2,Prate that decreased by<60 mL/min/1.73 m2 was significantly lower than that of *** long-term statin intake,GFR changed with the type of *** work is the first in Korea to compare each statin in terms of changes in the GFR after the statin prescription.

关键词： statin glomerular filtration rate HMG-CoA reductase inhibitor chronic kidney disease

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Relationship between Vesicoureteral Reflux and glomerular filtration rate in Children

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Current Medical Science 2020年第5期40卷 845-850页

作者： Wei ZHANG Hui-ming YI Xiao-le ZHANG Yong-hong YI Jian-hua ZHOU Li-ru QIU Department of Ultrasound Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Vesicoureteral reflux(VUR)is one of the most common urinary tract anomalies in children and causes renal damage and studies focusing on the effect of VUR on renal function are *** recruited 35 primary VUR patients with recurrent urinary tract infection(UTI)and 10 non-VUR patients with recurrent ***-enhanced voiding urosonography(ceVUS)was performed for VUR grading,and renal dynamic imaging was used for evaluating glomerular filtration rate(GFR,mL/min).Standardized GFR(sGFR),namely GFR/BSA(mL·min-1·m-2),was calculated based on the body surface area(BSA).Total sGFR(tsGFR,mL·min-1·m-2)was obtained from the sum of sGFR on the left and right sides of all the *** risk of renal regurgitation was equal in the unilateral reflux *** sGFR of children with grade Ⅳ(45.74±18.05mL·min-1·m-2)and grade V(49.67±23.63mL·min-1·m-2)reflux was significantly lower than that in children with grade Ⅱ(77.69±22.21 mL·min-1·m-2).The renal function compensation of contralateral non-reflux kidney increased in unilateral reflux group,which was higher than that in the control group and level Ⅱ,Ⅳ and Ⅴ of reflux group *** VUR group of the same grade,sGFR decreased with the age at *** unilateral grade V refux group,the tsGFR was lower than that in the unilateral grade I reflux group(133.51±48.21 vs.186.87+53.49mL·min-1·m-2).The patients with VUR of unilateral grade Ⅱ were significantly older than those with VUR of unilateral grades Ⅱ and Ⅳ.This study indicates that severe VUR is significantly associated with decreased renal ***,VUR should be diagnosed early and managed individually.

关键词： vesicoureteral reflux renal dynamic imaging glomerular filtration rate renal damage children

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Dynamic changes of estimated glomerular filtration rate are conversely related to triglyceride in non-overweight patients

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World Journal of Clinical Cases 2022年第31期10卷 11371-11380页

作者： Si-Qi Liu Xiu-Jun Zhang Yuan Xue Rui Huang Jian Wang Chao Wu Yi-Shan He Ya-Ru Pan Long-Gen Liu Changzhou Clinical Medical College Nanjing Medical UniversityChangzhou 213000Jiangsu ProvinceChina Institute of Hepatology The Third People’s Hospital of ChangzhouChangzhou 213000Jiangsu ProvinceChina Department of Infectious Diseases Nanjing Drum Tower HospitalNanjing 210008Jiangsu ProvinceChina

BACKGROUND Correlation between Triglyceride(TG)and estimated glomerular filtration rate(eGFR)remains largely unknown in overweight and non-overweight *** To investigated the dynamic changes of eGFR and lipid profiles during 3-year tenofovir disoproxil fumarate(TDF)treatment in patients with chronic hepatitis B(CHB)and *** A total of 202 CHB patients who received TDF treatment at the Third People's Hospital of Changzhou(Changzhou,China)and Nanjing Drum Tower Hospital(Nanjing,China)between January 2016 and May 2018 were retrospectively *** to the body mass index(BMI)at the initiation of TDF treatment,CHB patients were divided into overweight(BMI≥25 kg/m^(2))and nonoverweight(BMI0.05).More patients in non-overweight group achieved alanine aminotransferase normalization compared with those in overweight group(χ^(2)=11.036,P<0.01).In non-overweight patients,the eGFR significantly declined in the 1^(st) year(P<0.01),then remained at a relatively lower *** significantly declined in the 2^(nd) year(P=0.02)and increased in the 3^(rd) ***,TG was negatively correlated with GFR at the four-time points(P=0.002,0.030,0.007,0.008,respectively).In overweight patients,eGFR and TG remained relatively stable during the 3-year treatment,and eGFR showed no significant relationship with ***,multivariate analysis showed that age[P<0.01,95%CI(0.97-1.005)]and baseline eGFR[P<0.01,95%CI(5.056-33.668)]were independent risk factors for eGFR<90 mL/(min·1.73 m^(2))at the 3^(rd) *** Dynamic changes in renal function were conversely related to TG during TDF treatment in patients with CHB and normal BMI,but not with overweight.

关键词： Tenofovir disoproxil fumarate Hepatitis B virus glomerular filtration rate Overweight Body mass index

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Association of glomerular filtration rate with arterial stiffness in Chinese women with normal to mildly impaired renal function

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Journal of Geriatric Cardiology 2012年第2期9卷 158-165页

作者： Su-Yan Bian Hong-Yang Guo Ping Ye Lei-Ming Luo Hong-Mei Wu Wen-Kai Xiao Li-PingQi He-Peng Yu Liu-Fa Duan The Second Department of Geriatric Cardiology Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China Departmen of Cardiology Chinese PLA General Hospital 28 Fuxing Road Beijing 100853 China

Objective Both decreased glomemlar filtration rate （GFR） and arterial stiffness were considered as risk factors for atherosclerosis. Previous studies have suggested the association between central arterial stiffness and the degree of GFR loss. Whether decreased GFR contributes to peripheral artery stiffness remains controversial. Moreover, data analyzed from a cohort of Chinese women are rare. Our aim was to explore the relationship between GFR and regional arterial stiffness in Chinese women. Methods In this cross-sectional study, we randomly recruited 1131 adult women residents with GFR 〉 60 mL/min per 1.73 m2 estimated by the Chinese Modification of Diet in Renal Disease equation from three large communities. Central and peripheral arterial stiffness were estimated simultaneously by measuring carotid-femoral pulse wave velocity （PWVcf） and carotid-radial PWV （PWVcr） using a validated automatic device. Augmentation Index at heart rate 75 beats/minutes （AIx-75） was measured by pulse wave analysis as a composite parameter reflecting both large and distal arterial properties. Results The mean estimated GFR （eGFR） of the study group was 100.05 ＋ 23.26 mL/minute per 1.73 m2. Subjects were grouped by tertiles of eGFR level. PWVef and AIx-75 increased ongoing from the top to the bottom eGFR tertile, while the values of PWVcr were comparable. Both univariate Pearson correlations and multiple stepwise regression analyses showed that eGFR significantly correlated to PWVcf, but not to PWVcr and AJx-75. Conclusions In Chinese women with normal to mildly impaired renal function, decreased eGFR affected carotid-to-femoral rather than carotid-to-radial stiffening. This provides rational to conduct future prospective studies to investigate predictors of atherosclerosis in this population.

关键词： Arterial stiffness Augmentation index Pulse wave velocity glomerular filtration rate Chinese women

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Relative performance of two equations for estimation of glomerular filtration rate in a Chinese population having chronic kidney disease

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Chinese Medical Journal 2012年第4期000卷 599-603页

作者： Li Jiang-tao Xun Chen Cui Chun-li Wang Hui-fang Wu Yi-tai Yun Ai-hong Jiang Xiao-feng Ma Jun Tongji Univ Tongji Hosp Dept Nephrol Sch Med Shanghai 200065 Peoples R China

Background The new Chronic Kidney Disease Epidemiology Collaboration （CKD-EPI） equation was developed to address the systematic underestimation of glomerular filtration rate （GFR） by the Modification of Diet in Renal Disease （MDRD） Study equation in patients with relatively well-preserved kidney *** of the new equation in the Chinese population is *** goal of the present study was to compare performance of these two equations in Chinese patients with chronic kidney disease （CKD）.Methods We enrolled 450 Chinese patients （239 women and 211 men） with CKD in the present *** renal dynamic imaging method was used to measure the referenced standard GFR （rGFR） for comparison with estimations using the two *** overall performance was assessed with the Bland-Altman method and receiver-operating characteristics （ROC） *** of the two equations in lower and higher estimated GFR （eGFR） subgroups was further *** Both eGFRs correlated well with rGFR （r=0.88,0.81,P〈0.05）.In overall performance,the CKD-EPI equation showed less bias,higher precision and improved accuracy,and was better for detecting *** the higher-eGFR subgroup,the CKD-EPI equation corrected the underestimation of GFR by the abbreviated MDRD *** The CKD-EPI equation outperformed the abbreviated MDRD equation not only in overall performance but also in the subgroups *** the present,the CKD-EPI equation appears to be the first-choice prediction equation for estimating GFR.

关键词： chronic kidney disease glomerular filtration rate abbreviated modification of diet in renal disease equation Chronic Kidney Disease Epidemiology Collaboration equation

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Prediction of contrast-induced nephropathy in diabetics undergoing elective percutaneous coronary intervention： role of the ratio of contrast medium volume to estimated glomerular filtration rate

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Chinese Medical Journal 2011年第6期124卷 892-896页

作者： HAO Guo-zhen JIANG Yun-fa FAN Wei-ze LI Shi-qiang Department of Cardiology Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China

Background Diabetic patients undergoing percutaneous coronary intervention （PCI） have a higher incidence of contrast-induced nephropathy （CIN） than nondiabetic patients, and no pharmacological approach has been demonstrated to offer consistent protection. Therefore, identifying individuals who are at increased risk becomes essential. This study was designed to assess the predictive role of the ratio of contrast medium volume to estimated glomerular filtration rate （CMV/eGFR） in diabetic patients undergoing elective PCI who developed *** We retrospectively investigated clinical factors associated with the development of CIN in 114 diabetic patients who had undergone elective PCI. The risk factors for CIN included age, gender, body mass index （BMI）, left ventricular ejection fraction （LVEF）, hemoglobin （Hb）, fasting plasma glucose （FPG）, hemoglobin A1c （HbA1c）, volume of contrast medium, basic levels of serum creatinine （Scr）, the number of treated vessels and the number of stents *** conducted a stepwise regression analysis to evaluate the predictive role of these risk factors in the incidence of *** The incidence of CIN was 18.4% （21/114）. There were no significant differences in age, gender, BMI, LVEF, Hb,FPG, HbA1c, and incidence of hypertension and number of acute myocardial infarction （AMI） in patients between the CIN （n=21） and the non-CIN （n=93） groups. However, the eGFR was significantly lower （（72.0±12.5） ml·min-1·1.73 m-2 vs.（82.0±16.5）ml·min-1·1.7m-2, P=0.010）, and the basic serum creatinine level （（1.07±0.12） mg/dl vs.（0.97±0.19） mg/dlP=0.014） was significantly higher in the CIN group. In addition, the volume of contrast medium was significantly larger （（253±75）ml vs. （211±71）ml, P=0.017） and the CMV/eGFR ratio was significantly greater （3.64±1.26 vs.2.70±1.11, P=0.001） in the CIN group. Stepwise regression analysis showed that the CMV/eGFR ratio was a significant independent predictor for the development of CIN （P=0.001）. At a cut-off

关键词： contrast-induced nephropathy diabetes mellitus contrast media glomerular filtration rate percutaneous coronary intervention

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Changes in body composition in relation to estimated glomerular filtration rate and physical activity in predialysis chronic kidney disease

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Chronic Diseases and Translational Medicine 2022年第4期8卷 305-313页

作者： Prathiksha R.Bhat Asna Urooj Srinivas Nalloor Department of Studies in Food Science and Nutrition ManasagangotriUniveristy of MysoreMysuruKarnatakaIndia Department of Nephrology Apollo BGS hospitalsMysuruKarnatakaIndia

Background: Early body composition changes, associated with physical inactivity and disease advancement are devastating for patient-related outcomes in predialysis chronic kidney disease (CKD), thus warranting a detailed analysis of body composition beyond conventional ***: The study included 40 subjects diagnosed with CKD;recruited between January to May 2021. Body composition was measured using the multifrequency analyzer, InBody 770. International Physical Activity Questionnaire-Short Form was used to assess physical activity. Suitable statistical analyses were performed using SPSS ***: The mean age of the subjects was 58.68 ± 12.24 years. Sarcopenic obesity was prevalent in 62.5% of the subjects. Body mass index under identified obesity by 15% compared to percent body fat, especially in subjects with low muscle mass. The decline in a unit of estimated glomerular filtration rate (eGFR) significantly correlated with a decrease in weight (p = 0.02), body fat mass (p = 0.05), visceral fat area (p = 0.05), and phase angle (p = 0.01) with marginal changes in waist–hip ratio and extracellular water/total body water. The effect of physical activity on skeletal muscle mass was homogeneous between low and moderate levels, but significantly different from high activity ***: Changes in fat and fluid compartment were associated with eGFR decline, whereas higher physical activity positively affected body composition.

关键词： body composition electric impedance exercise glomerular filtration rate malnutrition

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The Choice Between Three Simple Methods for glomerular filtration rate Assessment in Different Stages of Chronic Parenchymal Renal Diseases

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Journal of Physical Science and Application 2012年第9期2卷 372-380页

作者： Milena P. Rajic Marina Vlajkovic Slobodan Ilic Milos Stevic Vladan Sekulic Ljubinka Velickovi Jankovi Department of Nuclear Medicine University of Nis Medical School and Clinical Center Dr Zoran Dindi6 48 18000 NiJ Serbia Departement of Pathology University of Nis Medical School and Clinical Center Dr Zoran Dindic 48 18000 Nis Serbia

glomerular filtration rate （GFR） can be measured （mGFR） after intravenous application of indicators that are eliminated by kidneys or estimated （eGFR） using mathematic equations. We have compared eGFR obtained by the chronic kidney diseases epidemiology collaboration （CKD-EPI） and the Modification of diet in renal disease （MDRD） Study equations with GFR measured by technetium-99m diethylene triamine penta-acetic acid （99m^Te-DTPA） renal clearance in different stages of renal diseases in order that obtained results may contribute to more adequate choice of methods for the GFR assessment in relation to the type and stage of kidney disease. The study included a total of 189 participants with diabetes mellitus （DM）, glomerulonephritis （GN）, Balkan endemic nephropathy （BEN） and healthy subjects. 99m^Tc-DTPA clearance （ml/min/1.73 m^2） was calculated from the regression equation based on high correlation between distribution volume of radiopharmaceutical and clearance values obtained by multiple blood samples. For blood sample taken at 3 h and 4 h, clearance was calculated according to the equations： y = -0.0128x^2 ＋ 3.077x - 30.3, and y = -0.00628x^2 ＋ 2.066x - 19.3, where y is clearance, and x is distribution volume. MDRD-GFR （ml/min/l.73 m2） was calculated from equation： 186 × Scr^-1154 × age^-0.203 × 0.742 if female. CKD-EPI-GFR was calculated from equation： 141 × min（Scr/K, 1）^ α ×max（Scr/K, 1）^-1 209 × 0.993age × 1.018 if female, where Scr is serum creatinine, n is 0.7 for females and 0.9 for males, c~ is -0.329 for females and -0.411 for males, min indicates the minimum of Scr/K or 1, and max indicates the maximum of Scr/κ or 1. Irrespective of renal disease, both equations underestimated radionuclide clearance at mGFR 〉 90 ml/min/1.73 m^2 （91.7 ± 18.8 and 88.2 ± 22.0 vs. 121± 19.6, p〈0.0001） and at mGFR 60-89 ml/min/1.73 m^2 （67.1 ±19.9 and 65.8 ± 19.9 vs. 75.8 ± 9.2, p 〈 0.05 and p 〈 0.005）. They were also significantly lower than mGFR in DM patients with GFR 〉_

关键词： Renal disease glomerular filtration rate 99^mTc-DTPA renal clearance CKD-EPI equation MDRD equation.

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Estimation of glomerular filtration rate: Which Formula to Apply in G-Spot Subjects Aged 1 - 17 Years?

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Open Journal of Nephrology 2021年第3期11卷 397-402页

作者： Hamadoun Yattara Djibril Mamadou Couliblay Nouhoum Coulibaly Pamela Samiza Seydou Sy Arboncana Maiga Djeneba Diallo Moustapha Tanagra Alkaya Touré Magara Samaké Niagalé Diakité Aboubacar Sidiki Fofana Ibrahim Izetiengou Maiga Sahare Fongoro Nephrology and Hemodialysis Department of the Point G University Hospital Bamako Mali Medical biology Laboratory Service of the Point G University Hospital Bamako Mali Nephrology Department of the Regional Hospital of Kayes Kayes Mali

Introduction: Morbidity and mortality in paediatric practice is dominated in Africa by malaria, diarrhoeal diseases and acute respiratory infections. Aim: In order to evaluate the glomerular filtration rate (GFR) with the formulas commonly used by medical laboratories, we proposed to undertake this study. Patients and Method: This was a descriptive, prospective and cross-sectional study conducted at the PA and KA medical biology laboratory in Bamako Hamdalaye ACI 2000 in collaboration with the medical biology and hospital hygiene laboratory service at the Point G University Hospital. Results: During the study period, we recruited 360 subjects, 189 of whom were male (52.5%) and 171 female (47.5%). The mean age was 8.75 ± 4.8 years with extremes of 1 and 17 years. Subjects aged 15 to 17 years were the most numerous. The reference means GFR of the subjects according to age was with the SCHWARTZ formula 179.16 ± 50.47 with extremes of 173.93 and 184.39;with CKD-Epi 37.63 ± 11.25 with extremes of 36.46 and 38.79;with MAYO 107.87 ± 18.11 with extremes of 105.99 and 109.75 and MDRD 350.83 ± 251.15 with extremes of 324.79 and 376.86. Conclusion: The Mayo formula showed a better distribution around the mean than other formulas for estimating the glomerular filtration rate.

关键词： glomerular filtration rate Reference Value Young Subjects

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