检索结果-南通市图书馆

glomerular disease Associated with Takayasu Arteritis:6 Cases Analysis and Review of the Literature

Chinese Medical Sciences Journal 2009年第2期24卷 69-75页

作者： Xue-mei Li Wen-ling Ye Yu-bing Wen Hang Li Li-meng Chen Dong-yan Liu Xue-jun Zeng Xue-wang Li Department of Nephrology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China Department of General Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To evaluate the clinical features,renal histopathology and therapeutic response to glucocorticoid and immunosuppressive agents in patients with glomerular disease associated with Takayasu arteritis(TA).Methods Patients with TA and renal biopsy-confirmed glomerular disease were investigated *** of them had renal artery stenosis or occlusive *** Six patients with glomerulopathy,accounting for 3.75% of the 160 TA patients admitted to our hospital at the same period,were *** of them were females with a mean age of 35.5 ± 10.0 *** cases presented with lower extremity *** tests showed that one was nephrotic syndrome,three were nephrotic range proteinuria,and two of them had mild renal *** other two patients were asymptomatic microscopic hematuria and *** pathology revealed mild immunoglobulin A nephropathy in two cases,mild mesangial proliferative glomerulonephritis(GN),membranoproliferative GN,minimal change disease,and fibrillary GN in one case *** cases received glucocorticoids and cyclophosphamide *** and microscopic hematuria disappeared in 2 to 4 weeks after the initiation of therapy in three *** patient with membranoproliferative GN also reached complete remission of proteinuria and recovered renal function 6 months after the *** TA may induce glomerular disease as a part of its histological *** from ischemic glomerular disease,glomerular disease should be suspected when TA patients have microscopic hematuria or proteinuria,that may be therapeutically responsive to glucocorticoids and immunosuppressive agent in relative early phase.

关键词： Takayasu arteritis glomerular disease glomerulonephritis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Review of plasma exchange and rituximab for prevention of recurrent focal segmental glomerulosclerosis after a prior graft loss

引用

World Journal of Transplantation 2024年第4期14卷 133-139页

作者： Sophie Gharaei Hashim Abbas Durga Anil Kanigicherla Manchester Medical School University of ManchesterManchester M139WLUnited Kingdom Department of Renal Medicine Manchester University NHS Foundation TrustManchester M139WLUnited Kingdom

BACKGROUND Focal segmental glomerulosclerosis(FSGS)often recurs after transplantation,leading to graft dysfunction and graft *** who have lost prior grafts due to recurrence are at particularly high risk of re-recurrence in subsequent *** and plasma exchange have been used pre-emptively to prevent post-transplant ***,the efficacy of such preventative measures remains *** To investigate the outcomes of preventative rituximab and plasma exchange for recurrent FSGS in transplant recipients after prior graft *** We conducted a systematic review of 11 studies with 32 patients who had experienced prior graft loss due to post-transplant FSGS recurrence and were treated with either pre-emptive plasma exchange alone,rituximab alone,or a combination of *** Overall,47%of the 32 patients experienced recurrence despite prophylactic ***-recurrence was seen in 25%(1/4)with pre-emptive rituximab alone,and 45%recurrence(9/20)with plasma exchange ***-recurrence was noted in 63%with the use of combined plasma exchange and *** There is a paucity of available evidence in the literature to draw clear conclusions on the benefits of pre-emptive measures to prevent FSGS *** small sample sizes and variations in protocols call for larger and controlled studies to serve this patient population at high risk of recurrence and graft loss.

关键词： Focal segmental glomerulosclerosis glomerular disease Plasma exchange Rituximab Transplantation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Epidemiology of biopsy-proven glomerular diseases in Chinese children: A scoping review

引用

Chronic diseases and Translational Medicine 2022年第4期8卷 271-280页

作者： Yetong Li Yue Yang Li Zhuo Dan Wu Wenge Li Xiaorong Liu Department of Nephrology Beijing Children's HospitalNational Centerfor Children's HealthCapital Medical UniversityBeijingChina Department.of Nephrology China-Japan Friendship HospitalCapital Medical UniversityBeijingChina

Background: glomerular disease is the leading cause of chronic kidney disease globally. No scoping review reports have focused on China’’s spectrum of glomerular diseases in children. This study aimed to systematically identify and describe retrospective studies on pediatric glomerular disease based on available data on sex, age, study period, and ***: Six databases were systematically searched for relevant studies from initiation to December 2021 in PubMed, Embase, Web of Science, Global Health Library, Wangfang Database, and ***: Thirty-four studies were identified in the scoping review, including 40,430 patients with biopsy-proven diagnoses. The proportion of boys was significantly higher than that of girls. In this study, 28,280 (70%) cases were primary glomerular disease, 10,547 (26.1%) cases were diagnosed as secondary glomerular disease, and 1146 (2.8%) cases were hereditary glomerular disease. Minimal change disease is the most common glomerular disease among children in China, followed by mesangial proliferative glomerulonephritis, IgA nephropathy, and purpura nephritis. We observed increments in glomerular diseases in periods 2 (2001–2010) and 3 (2011–2021). The proportion of major glomerular diseases varies significantly in the different regions of ***: The spectrum of pediatric glomerular diseases varied across sex, age groups, study periods, and regions, and has changed considerably over the past 30 years.

关键词： child and adolescent China glomerular disease kidney glomerulus renal biopsy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes(imPODs)

引用

Genes & diseases 2018年第2期5卷 137-149页

作者： Xinyi Yu Liqun Chen Ke Wu Shujuan Yan Ruyi Zhang Chen Zhao Zongyue Zeng Yi Shu Shifeng Huang Jiayan Lei Xiaojuan Ji Chengfu Yuan Linghuan Zhang Yixiao Feng Wei Liu Bo Huang Bo Zhang Wenping Luo Xi Wang Bo Liu Rex C.Haydon Hue H.Luu Tong-Chuan He Hua Gan Departments of Nephrology Orthopaedic SurgeryCardiologyGeneral SurgeryPlastic Surgeryand Clinical Laboratory MedicineThe First Affiliated Hospital of Chongqing Medical UniversityChongqing400016China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine and the Affiliated Hospitals of Chongqing Medical UniversityChongqing400016China Department of Biochemistry and Molecular Biology China Three Gorges University School of MedicineYichang443002China Department of Clinical Laboratory Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang330031China Key Laboratory of Orthopaedic Surgery of Gansu Province and the Department of Orthopaedic Surgery The Second Hospital of Lanzhou UniversityLanzhou730030China

glomerular podocytes are highly specialized epithelial cells and play an essential role in establishing the selective permeability of the glomerular filtration barrier of *** the viability and structural integrity of podocytes is critical to the clinical management of glomerular diseases,which requires a thorough understanding of podocyte cell *** mature podocytes lose proliferative capacity,a conditionally SV40 mutant tsA58-immortalized mouse podocyte line(designated as tsPC)was established from the Immortomouse over 20 years ***,the utility of the tsPC cells is hampered by the practical inconvenience of culturing these *** this study,we establish a user-friendly and reversibly-immortalized mouse podocyte line(designated as imPOD),on the basis of the tsPC cells by stably expressing the wildtype SV40 T-antigen,which is flanked with FRT *** show the imPOD cells exhibit long-term high proliferative activity,which can be effectively reversed by FLP *** imPOD cells express most podocyte-related markers,including WT-1,Nephrin,Tubulin and Vinculin,but not differentiation marker *** imPOD cells do not form tumor-like masses in *** further demonstrate that TGFb1 induces a podocyte injury-like response in the FLP-reverted imPOD cells by suppressing the expression of slit diaphragm-associated proteins P-Cadherin and ZO-1 and upregulating the expression of mesenchymal markers,a-SMA,Vimentin and Nestin,as well as fibrogenic factors CTGF and ***,our results strongly demonstrate that the newly engineered im-POD cells should be a valuable tool to study podocyte biology both under normal and under pathological conditions.

关键词： Chronic kidney disease FLP recombinase glomerular disease Glomerulus Immortalization Nephropathy Podocyte SV40 T antigen

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multifaceted relationship between diabetes and kidney diseases:Beyond diabete

引用

World Journal of Diabetes 2023年第10期14卷 1450-1462页

作者： Pasquale Esposito Daniela Picciotto Francesca Cappadona Francesca Costigliolo Elisa Russo Lucia Macciò Francesca Viazzi Department of Internal Medicine and Medical Specialties(DiMI) University of GenoaGenoa 16132Italy Unit of Nephrology Dialysis and TransplantationIRCCS Ospedale Policlinico San MartinoGenoa 16132Italy

Diabetes mellitus is one of the most common causes of chronic kidney *** involvement in patients with diabetes has a wide spectrum of clinical presentations ranging from asymptomatic to overt proteinuria and kidney *** development of kidney disease in diabetes is associated with structural changes in multiple kidney compartments,such as the vascular system and *** alterations include thickening of the glomerular basement membrane,loss of podocytes,and segmental mesangiolysis,which may lead to microaneurysms and the development of pathognomonic Kimmelstiel-Wilson *** lesions directly related to diabetes,awareness of the possible coexistence of nondiabetic kidney disease in patients with diabetes is *** nondiabetic lesions include focal segmental glomerulosclerosis,IgA nephropathy,and other primary or secondary renal *** diagnosis of these conditions is crucial in guiding clinical management and therapeutic ***,the relationship between diabetes and the kidney is bidirectional;thus,new-onset diabetes may also occur as a complication of the treatment in patients with renal ***,we review the complex and multifaceted correlation between diabetes and kidney diseases and discuss clinical presentation and course,differential diagnosis,and therapeutic opportunities offered by novel drugs.

关键词： Diabetes Diabetic kidney disease Nondiabetic kidney disease Biomarkers glomerular disease Kidney biopsy Sodium-glucose cotransporter-2 inhibitors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：