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Goodpasture syndrome and hemorrhage after renal biopsy: A case report

World Journal of Clinical Cases 2020年第2期8卷 404-409页

作者： Wei-Long Li Xi Wang Shu-Yuan Zhang Zi-Gan Xu Ying-Wei Zhang Xing Wei Chun-Di Li Ping Zeng Shao-Dong Luan Department of Nephrology Shenzhen Longhua District Central Hospital

BACKGROUND Goodpasture syndrome(GS) is a rare disease, the morbidity of which is estimated to be 0.5-0.8 per million per year. Hemorrhage is the most serious complication in renal biopsy. Despite the fact that both GS and hemorrhage after renal biopsy are rare, it has not been reported that they are likely to occur in the same *** SUMMARY A 30-year-old man with diffuse pulmonary hemorrhage and rapid progressive renal function caused by anti-glomerular basement membrane disease presented atypical symptoms without hemoptysis, accompanied by life-threatening hypoxemia. Plasmapheresis was performed, and glucocorticoids and cyclophosphamide were administered. The patient started to show signs of improvement. Percutaneous renal biopsy is an appropriate diagnostic measure that is commonly safe, but this patient experienced hemorrhage after operation,thus necessitating embolization of the renal artery to stop the bleeding. The patient’s condition was improved, and the serum anti-glomerular basement membrane antibody level was 106 AU/m L(normal range: < 24 AU/m L) and slowly decreased. His discharge medications were oral daily prednisone(30 mg)and continued maintenance *** GS is a rare organ-specific autoimmune disease that is invariably ubiquitous in the lung and kidney areas. Renal biopsy is the appropriate procedure for the treatment of GS disease, although it is an invasive measure.

关键词： Goodpasture disease Anti-glomerular basement membrane disease Renal biopsy Hemorrhage glomerular basement membrane Case report

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Albumin Modulates the Production of Matrix Metalloproteinases-2 and -9 in Podocytes

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2009年第6期29卷 710-714页

作者：方展何方方陈珊孙希锋朱忠华张春 Department of Nephrology Union Hospital Tongji Medical College Huazhong University of Science and Technology

To investigate the effects of albumin on the production of matrix metalloproteinases-2 （MMP-2） and matrix metalloproteinases-9 （MMP-9）in podocytes. Podocytes were treated with bovine serum albumin （BSA） at the concentration of 0.1, 0.5, 1, 2 g/L, respectively. Conditioned media were harvested 12, 24, 48 and 72 h after the treatment. The expression of MMP-2 and MMP-9 was assayed by gelatin zymography, RT-PCR and Western blotting analysis. Our results showed that in comparison with the control group, BSA increased the expression of MMP-2 and MMP-9 mRNA and protein in a doseand time-dependent manner （P〈0.05）. Meanwhile, the enzymatic activities of MMP-2 and MMP-9 in the culture supernatants of podocytes were also increased （P〈0.05）. It is concluded that albumin up-regulated the expression of MMP-2 and MMP-9 at gene and protein levels in a time-and dose-dependent manner.

关键词： podocytes albumin matrix metalloproteinases glomerular basement membrane

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Production and Characterization of Recombinant Rat Non-Collagen Domain of α3 Chain of Type IV Collagen α3 (IV) NC1 Antigen

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CellBio 2016年第3期5卷 27-48页

作者： Afsana Munni School of Life Science University of Bedfordshire Luton UK

The glomerulonephritis disease is characterized by inflammation of glomeruli or small blood vessels in the kidney that causes kidney diseases. The reason of glomerulonephritis disease is to deposit the anti-GBM auto antibody in the glomerular basement membrane. The type IV collagen is the main component of glomerular basement membrane that has α3 chain of type (IV) collagen of non-collagenous domain which contains N-terminal 7S domain, a triple helical collagenous domain and C-terminal non-collagenous glomerular domain (NC1). The amino terminal of α3 (IV) NC1 that induces the Experimental Autoimmuno Glomerulonephritis (EAG) in rat model has been identified. The recombinant rat α3 (IV) NC1 antigen has nine amino acid spans that are consistent with antibody or T cell epitope that induces in EAG. The research is carried out on the recombinant rat α3 (IV) NC1 production, purification, quantification, and characterization. The circulation of anti-GBM antibody in glomerular basement membrane can be measured by the ELISA assay. In addition, the recombinant rat antigen is secreted in HEK293 cell supernatant that is purified by Anti-FLAG M2 monoclonal IgG antibody affinity column and characterized and quantified by SDS-PAGE gel electrophoresis and Western blotting techniques.

关键词： Auto-Immuno Kidney Disease Glomerulonephritis Disease glomerular basement membrane α3 (IV) NC1-Non-Collagen Domain of α3 Chain of Type IV Collagen α3 (IV) Antibody(Ab) Antigen (Ag) Anti glomerular basement membrane Experimental Autoimmune Glomerulonephritis Enzyme-Linked Immunosorbent Assay (ELISA) Human Embryonic Kidney (HEK) Ig-Immunoglobulin (IgG IgA) IgAN-IgA nephropathy

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