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Mechanism of ginsenoside rh1 in Regulating Breast Cancer Cell Extravasation Based on CCL20- CCR6

Proceedings of Anticancer Research 2022年第5期6卷 58-63页

作者： Wenming Zhao Binjuan Zhou Jirui Sun Haizhi Qiao Jinmei Li Shuangqiu Ma Xu Wang Jinku Zhang Department of Pathology Baoding First Central HospitalBaoding 071000Hebei ProvinceChina

Objective:To explore the regulatory mechanism of ginsenoside rh1 on breast cancer cell extravasation based on CCL20-CCR6.Methods:In 2021,a total of 34 patients with breast cancer were treated in Baoding First Central Hospital.During hospitalization,pathological examinations were performed,and all the patients were diagnosed with invasive ductal carcinoma.Out of the 34 cases,16 cases were found to have CCR6 expression in breast cancer tissues,in which they were recorded as the CCR6 expression group,whereas 18 cases did not have CCR6 expression;these cases were recorded as the CCR6 non-expression group.During the same period,21 normal patients were selected as the control group.The peripheral blood CCL20 level and the expression of CCR6 on the surface of CD3+T lymphocytes were analyzed.The extracts of cancer cells were collected,purified,and cultured,and the effect of ginsenoside rh1 on the invasion and metastasis of breast cancer cells was analyzed.Results:The peripheral blood CCL20 level in the CCR6 expression group was significantly higher than that in the CCR6 non-expression group and the control group,in which p12,24,and 48 hours,the cell survival rate of each dose group was significantly higher than that of the blank control group and the dimethyl sulfoxide(DMSO)group(pginsenoside rh1 can effectively regulate the invasion and migration of breast cancer cells.

关键词： CCL20 CCR6 ginsenoside rh1 Breast cancer

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A New Saponin Transformed from ginsenoside rh_1 by Bacillus subtilis

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Chinese Chemical Letters 2005年第3期16卷 359-361页

作者： GuoHongLI YueMaoSHEN KeQinZHANG LaboratoryforConservationandUtilizationofBio-resource YunnanUniversityKunming650091 TheStateKeyLaboratoryofPhytochemistryandPlantResourcesinWestChina KunmingInstituteofBotanyChineseAcademyofSciencesKunming650204

A novel saponin was isolated from the transformed products of ginsenoside rh1 by Bacillus subtilis. It's structure was determined to be 3-O-β-D-glucopyranosyl-6-O-β-D-gluco- pyranosyl-20 (S)-protopanaxatriol on the ... 详细信息

关键词： ginsenoside rh1 novel saponin biotransformation.

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Simultaneous quantification of ginsenoside Rg1 and its metabolites by HPLC–MS/MS:Rg1 excretion in rat bile, urine and feces

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Acta Pharmaceutica Sinica B 2016年第6期6卷 593-599页

作者： Chiyu He Ru Feng Yupeng Sun Shifeng Chu Ji Chen Chao Ma Jie Fu Zhenxiong Zhao Min Huang Jiawen Shou Xiaoyang Li Yuzhu Wang Jinfeng Hu Yan Wang Juntian Zhang State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences Beijing Analytical Application Center Shimadzu (China) Co. Ltd.

ginsenoside Rg1(Rg1), the major effective component of ginseng, has been shown to have multiple bioactivities, but low oral bioavailability. The aim of this study was to develop a simple, sensitive and rapid high performance liquid chromatography–tandem mass spectrometry(LC–MS/MS) method, which could be used to validate and quantify the concentrations of Rg1 and its metabolites in Sprague-Dawley rat bile,urine, and feces after oral administration(25 mg/kg). Calibration curves offered satisfactory linearity(r40.995)within the determined ranges. Both intra-day and inter-day variances were less than 15%, and the accuracy was within 80–120%. The excretion recoveries of Rg1, ginsenoside rh1(rh1), and protopanaxatriol(Ppt) in bile,urine, and feces combined were all greater than 70%. The fecal excretion recoveries of Rg1, rh1, and Ppt were40.11%, 22.19%, and 22.88%, respectively, whereas 6.88% of Rg1 and 0.09% of rh1 were excreted in bile.Urinary excretion accounted for only 0.04% of Rg1. In conclusion, the observed excretion profiles for Rg1 and its metabolites after oral administration are helpful for understanding the poor oral bioavailability of Rg1 and will aid further investigations of Rg1 as a pharmacologically active component.

关键词： ginsenoside Rg1 ginsenoside rh1 Protopanaxatriol Excretion LC–MS/MS

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