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ginkgo biloba extract alleviates fatty liver hemorrhagic syndrome in laying hens via reshaping gut microbiota

Journal of Animal Science and Biotechnology 2024年第1期15卷 277-294页

作者： Xinyue Yang Depeng Li Meihong Zhang Yuqing Feng Xiaolu Jin Dan Liu Yuming Guo Yongfei Hu State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background ginkgo biloba extract(GBE)is evidenced to be effective in the prevention and alleviation of metabolic disorders,including obesity,diabetes and fatty liver ***,the role of GBE in alleviating fatty liver hemorrhagic syndrome(FLHS)in laying hens and the underlying mechanisms remain to be ***,we investigated the effects of GBE on relieving FLHS with an emphasis on the modulatory role of GBE in chicken gut *** The results showed that GBE treatment ameliorated biochemical blood indicators in high-fat diet(HFD)-induced FLHS laying hen model by decreasing the levels of TG,TC,ALT and *** lipid accumulation and pathological score of liver were also relieved after GBE ***,GBE treatment enhanced the antioxidant activity of liver and serum by increasing GSH,SOD,T-AOC,GSH-PX and reducing MDA,and downregulated the expression of genes related to lipid synthesis(FAS,LXRα,GPAT1,PPARγand Ch REBP1)and inflammatory cytokines(TNF-α,IL-6,TLR4 and NF-κB)in the *** profiling analysis revealed that GBE treatment reshaped the HFD-perturbed gut microbiota,particularly elevated the abundance of Megasphaera in the ***,targeted metabolomic analysis of SCFAs revealed that GBE treatment significantly promoted the production of total SCFAs,acetate and propionate,which were positively correlated with the GBE-enriched gut ***,we confirmed that the GBE-altered gut microbiota was sufficient to alleviate FLHS by fecal microbiota transplantation(FMT).Conclusions We provided evidence that GBE alleviated FLHS in HFD-induced laying hens through reshaping the composition of gut *** findings shed light on mechanism underlying the anti-FLHS efficacy of GBE and lay foundations for future use of GBE as additive to prevent and control FLHS in laying hen industry.

关键词： Antioxidation Fecal microbiota transplantation FLHS ginkgo biloba extract Inflammation Megasphaera

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ginkgo biloba extract protects against depression-like behavior in mice through regulating gut microbial bile acid metabolism

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Chinese Journal of Natural Medicines 2023年第10期21卷 745-758页

作者： ZHOU Junchi FAN Qilin CAI Xiaoying ZHANG Youying HOU Yuanlong CAO Shuqi LIZiguang FENG Mengzhen WANG Qingqing ZHANG Jianbing WANG Guangi ZHENG Xiao HAO Haiping State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China Laboratory of Metabolic Regulation and Drug Target Discovery School of PharmacyChina Pharmaceutical UniversityNanjing 210009China WanBangDe Pharmaceutical Group Co. Ltd.Wenlin 317500China

Depression is a mental disorder with high morbidity,disability and relapse *** biloba extract(GBE),a traditional Chinese medicine,has a long history of clinical application in the treatment of cerebral and mental disorders,but the key mechanism remains incompletely *** we showed that GEB exerted anti-depressant effect in mice through regulating gut microbial *** protected against unpredictable mild stress(UMS)-induced despair,anxiety-like and social avoidance behavior in mice without sufficient brain *** microbiome transplantation transmitted,while antibiotic cocktail abrogated the protective effect of *** bacterial profiling and metabolomics assay revealed a potential involvement of Parasutterella excrementihominis and the bile acid metabolite ursodeoxycholic acid(UDCA)in the effect of *** administration induced depression-like behavior in ***,these findings suggest that GBE acts on gut microbiome-modulated bile acid metabolism to alleviate stress-induced depression.

关键词： ginkgo biloba extract Depression Gut microbiome Gut-brain axis Bile acid

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ginkgo biloba extract Ameliorates Scopolamine-induced Memory Deficits via Rescuing Synaptic Damage

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Current Medical Science 2022年第3期42卷 474-482页

作者： Gui-jiao ZHANG Dong ZHENG Huan YU Xiao-ping LUO Wei WU Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective Alzheimer’s disease(AD)is the most common age-related neurodegenerative *** evidence suggests that synaptic dysfunction is associated with the onset and progression of ***,ginkgo biloba extract(EGb)is one of the most frequently investigated herbal medicines for enhancing cognition and alleviating neurodegenerative *** study aimed to investigate the effect and the mechanism of EGb on AD-like synaptic *** Scopolamine(SCO)-induced rats were used to mimic AD-like memory *** water maze test and fear conditioning test were conducted to evaluate the memory status of rats in response to different ***,the synapse alterations were assessed by Golgi staining,and Western blotting was conducted to assess the protein expression of PSD95,GluN2B,synapsin-1,and *** transcription quantitative polymerase chain reaction was applied to detect the mRNA expression of PSD95 and the levels of miR-1-3p/*** EGb supplement alleviated the learning and memory deficits induced by SCO in behavioral ***,EGb treatment attenuated synaptic damage elicited by SCO,manifested as increased dendritic spine density and the proportion of mushroom-type spines in hippocampal *** investigation indicated that EGb rescued the expression of synaptic-related proteins,especially PSD95,and decreased the levels of miR-1-3p/miR-206-3p in the rat *** The application of EGb effectively treats SCO-induced memory impairments probably by suppressing miR-1-3p/miR-206-3p and elevating the expression of PSD95.

关键词： ginkgo biloba extract Alzheimer’s disease synapse PSD95 MiR-1 MiR-206

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ginkgo biloba extract suppresses hypertrophy and extracellular matrix accumulation in rat mesangial cells

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Acta Pharmacologica Sinica 2006年第9期27卷 1222-1230页

作者： Jian-yun WANG~2 Xiao-xing YIN~(2,6)Yun-ming WU~2 Dao-quan TANG~2 Yuan-yuan GAO~2 Mei-rong WAN~4 Xiao-yu HOU~3 Bei ZHANG~5 2 Department of Pharmacy,3 Provincial Key Lab for Brain Diseases Bioinformation,Xuzhou Medical College,Xuzhou 221002,China 4 Center-Laboratory,Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002,China 5 Department of Obstetrics and Gynecology,The Third People's Hospital of Xuzhou,Xuzhou 221002,China Department of Pharmacy Xuzhou Medical College Xuzhou China Center-Laboratory Affiliated Hospital of Xuzhou Medical College Xuzhou China Provincial Key Lab for Brain Diseases Bioinformation Xuzhou Medical College Xuzhou China Department of Obstetrics and Gynecology The Third People's Hospital of Xuzhou Xuzhou China

Aim:To observe the effects of ginkgo biloba extract（EGb）on the hypertrophy ofmesangial cells and the accumulation of extracellular matrix（ECM）in ***:Cultured mesangial cells were allotted into 7 groups:normal group,solvent control group,high glucose group,low dose of EGb group,moderatedose of EGb group,high dose of EGb group,and captopril *** of cellantioxidases,S phase percentage and G0/G1phase percentage,collagen Ⅳ andlaminin,Smad2/3 and Smad7,TGF-β1mRNA were measured by different ***:For EGb-treated groups,when compared with high glucose group,thecell percentage of S phase was raised and the percentage of G0/G1was *** intensity of oxidative stress was *** expression of Smad2/3 wasgreatly decreased and Smad7 was *** Ⅳ,laminin and TGF-β1mRNA were also ***:EGb can suppress cell hypertrophy andthe accumulation of ECM in rat mesangial cells,which means it could play a vitalrole in the delay of glomerulosclerosis in diabetic nephropathy.

关键词： ginkgo biloba extract glomerulosclerosis oxidative stress TGF-β1 Smads

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ginkgo biloba extract for Angina Pectoris:A Systematic Review

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Chinese Journal of Integrative Medicine 2015年第7期21卷 542-550页

作者：孙天王显徐浩 Graduate School Beijing University of Chinese Medicine Cardiovascular Diseases Center Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Beijing University Cardiology Research Institute of Traditional Chinese Medicine Cardiovascular Diseases Center Xiyuan HospitalChina Academy of Chinese Medical Sciences

Objective： To evaluate the efficacy and safety of ginkgo biloba extract for patients with angina pectoris according to the available evidence. Methods： Electronic databases were searched for all of the randomized controlled trials （RCTs） of angina pectoris treatments with ginkgo biloba extract, either alone or combined with routine Western medicine （RWM）, and controlled by untreated, placebo, Chinese patent medicine, or RWM treatment. The RCTs were retrieved from the following electronic databases： PubMed/MEDLINE, ProQuest Health and Medical Complete, Springer, Elsevier, and ProQuest Dissertations and Theses, Wanfang Data, China National Knowledge Infrastructure （CNKI）, VIP database, China Biology Medicine （CBM）, Chinese Medical Citation Index （CMCI）, from the earliest database records to December 2012. No language restriction was applied. Study selection, data extraction, quality assessment, and data analyses were conducted according to the Cochrane standards. RevMan 5.1.0 provided by Cochrane Collaboration The data were analysed by using. Results： A total of 23 RCTs （involving 2,529 patients） were included and the methodological quality was evaluated as generally low. ginkgo biloba extract with RWM was more effective in angina relief and electrocardiogram improvement than RWM alone. Reported adverse events included epigastric discomfort, nausea, gastrointestinal reaction, and bitter taste. Conclusions： ginkgo biloba extract may have beneficial effects on patients with angina pectoris, although the low quality of existing trJals makes it difficult to draw a satisfactory conclusion. More rigorous, high quality clinical trials are needed to Drovide conclusive evidence.

关键词： ginkgo biloba extract angina pectoris systematic review Chinese medicine

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ginkgo biloba extract EGb 761^® Improves Central Vestibular Vertigo in Patients Undergoing Vestibular Exercises: A Randomised Placebo-Controlled Trial

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Neuroscience & Medicine 2022年第3期13卷 91-102页

作者： Wolfgang Heide Birgit Adlung Cornelia Körtke Robert Hoerr Department of Neurology General Hospital Celle Celle Germany Private Practice for Radiology Bad Zwischenahn Germany Private Practice for Neurology Lübeck-St. Lorenz Süd Germany Research & Development Dr. Willmar Schwabe GmbH & Co. KG Karlsruhe Germany

Background: ginkgo biloba extract EGb 761® is widely used to treat various types of vertigo. Aims: An exploratory trial was conducted to evaluate the efficacy of EGb 761® in addition to vestibular exercises in central vestibular vertigo caused by vertebro-basilar ischaemia. Subjects and Methods: In this randomised, placebo-controlled, double-blind trial, 40 patients were enrolled in the vertigo clinic of a neurological university hospital and treated with daily doses of 240 mg EGb 761® or placebo for a period of 180 days. All patients regularly performed vestibular exercises in addition. Efficacy was assessed using: a visual analogue scale for the patients to rate the overall intensity of vertigo;a numeric scale for physician-rated change;a vertigo score based on intensity, duration, and frequency of vertigo;and electronystagmography. Results: Until day 180, the mean patient-rated intensity of vertigo decreased by 46% during EGb 761® treatment and by 19% with placebo (p ® group compared to the placebo group. Nystagmus or other eye movement disorders were present only in small subgroups of patients without sufficient statistical power to detect differences between treatment groups. Conclusions: EGb 761® alleviated vertigo caused by ischaemic lesions in the brainstem or cerebellum in patients undergoing vestibular exercises.

关键词： ginkgo biloba extract EGb 761® Randomised Controlled Trial (RCT) Vertigo Dizziness Vestibular Exercises

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Protective effects of ginkgo biloba extract on 6-hydroxydopamine-induced apoptosis in PC12 cells

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Neural Regeneration Research 2011年第33期6卷 2565-2572页

作者： Jie Wang Yanbo Cheng Jiale Yin Qian LU Xingshun Xu Xiaoxing Yin Department of Pharmacy Xuzhou Medical College Xuzhou 221006 Jiangsu Province China Department of Neurology Affiliated Hospital of Xuzhou Medical College Xuzhou 221002 Jiangsu Province China

The present study analyzed the protective effects of ginkgo biloba extract against 6-hydroxydopamine-induced PC12 cell apoptosis in a model of Parkinson＇s disease. The results showed that ginkgo biloba extract had a potent cytoprotective action and inhibited apoptosis of PC12 cells induced by 6-hydroxydopamine. ginkgo biloba extract decreased the ratio of Bax to Bcl-2 and markedly inhibited the activation of p53 and caspase-3. These experimental findings indicate that ginkgo biloba extract may significantly reduce the effects of oxidative stress induced by 6-hydroxydopamine in PC12 cells and suppress cell apoptosis. The potential effects of ginkgo biloba extract might be greater than those of levodopa in the treatment of Parkinson＇s disease.

关键词： Parkinson's disease ginkgo biloba extract apoptosis oxidative stress PC12 cells neural regeneration

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The Effect of 2,5-hexanedione on Myelin Protein Zero Expression,and Its Mitigation Using ginkgo biloba extract

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Biomedical and Environmental Sciences 2011年第4期24卷 374-382页

作者： ZHAO Lei LIU QingJun CHEN Hong DUAN HuaWei BIN Ping LIU Qing NIU Yong DAI YuFei ZHENG YuXin National Institute for Occupational Health and Poison Control and Key laboratory of Chemical Safety and Health Chinese Center for Disease Control and Prevention Beijing 100050 China

Objective To investigate the role of myelin protein zero （P 0） in 2,5-hexanedione （2,5-HD）-induced peripheral nerve injury,and the protective effect of ginkgo biloba extract （Egb761） on 2,5-HD-induced toxic peripheral *** After 4 weeks of treatment with 2,5-HD at different doses （50,100,200,400 mg/kg） in rats,changes in the levels of P 0 in rat sciatic nerves was investigated,and the effect of Egb761 on 2,5-HD-induced toxic peripheral neuropathy was *** The blood-nerve barrier （BNB） permeability of the sciatic nerve increased,and the expression of P 0 mRNA and P 0 protein decreased in a dose-dependent manner after treatment with 2,5-HD for 4 *** with Egb761 protected against BNB interruption,and inhibited P 0 mRNA and protein reduction during 2,5-HD *** with Egb761 significantly reduced loss of body weight （P0.01） and mitigated gait abnormalities （2.85±0.22） induced by 400 mg/kg 2,5-HD （P0.01）.It also reduced the signs of neurotoxicity induced by 2,*** 2,5-HD inhibited the expression of P 0 in a dose-dependent manner,and this may be an important mechanism by which toxic peripheral neuropathy is induced by 2,***761 has a protective effect against 2,5-HD-induced peripheral neurotoxicity in rats.

关键词： Myelin protein zero 2 5-hexanedione ginkgo biloba extract

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A ginkgo biloba extract promotes proliferation of endogenous neural stem cells in vascular dementia rats

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Neural Regeneration Research 2013年第18期8卷 1655-1662页

作者： Jiwei Wang Wen Chen Yuliang Wang School of Medicine Shandong University Department of Physiology Weifang Medical University

The ginkgo biloba extract EGb761 improves memory loss and cognitive impairments in patients with senile dementia. It also promotes proliferation of neural stem cells in the subventricular zone in Parkinson＇s disease model mice and in the hippocampal zone of young epileptic rats. However, it remains unclear whether EGb761 enhances proliferation of endogenous neural stem cells in the brain of rats with vascular dementia. In this study, a vascular dementia model was established by repeatedly clipping and reperfusing the bilateral common carotid arteries of rats in combination with an intraperitoneal injection of a sodium nitroprusside solution. Seven days after establishing the model, rats were intragastrically given EGb761 at 50 mg/kg per day. Learning and memory abilities were assessed using the Morris water maze and proliferation of endogenous neural stem cells in the subventricular zone and dentate gyrus were labeled by 5-bromo-2-deoxyuridine immunofluorescence in all rats at 15 days, and 1, 2, and 4 months after model establishment. The escape latencies in Morris water maze tests of rats with vascular dementia after EGb761 treatment were significantly shorter than the model group. Immunofluorescence staining showed that the number and proliferation of 5-bromo-2-deoxyuridine-positive cells in the subventricular zone and dentate gyrus of the EGb761-treated group were significantly higher than in the model group. These experimental findings suggest that EGb761 enhances proliferation of neural stem cells in the subventricular zone and dentate gyrus, and significantly improves learning and memory in rats with vascular dementia.

关键词： neural regeneration traditional Chinese medicine ginkgo biloba extract EGb761 vasculardementia neural stem cells subventricular zone dentate gyrus learning and memory grants-supported paper neuroregeneration

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Activity of ginkgo biloba extract and Quercetin on Thrombomodulin Expression and Tissue-type Plasminogen Activator Secretion by Human Umbilical Vein Endothelial Cells

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Biomedical and Environmental Sciences 2006年第4期19卷 249-253页

作者： WEN-JUN LAN XIAO-XIANG ZHENG Key Laboratory for Biomedical Engineering of Ministry of Education of China Zhejiang University （ Yuquan Campus） Hangzhou 310027 Zhejiang China

Objective In order to investigate the pharmacological properties of ginkgo biloba extract （GBE） on improving blood circulation, the regulating action of GBE and quercetin （a main flavonoid ingredient in GBE） on thrombomodulin （TM） expression and tissue-type plasminogen activator （t-PA） secretion was studied. Methods Using flow cytometer and gel image system respectively, we evaluated the TM expression and the t-PA secretion by human umbilical vein endothelial cells （HUVECs） in vitro. Results The increase of TM expression on HUVECs surface was induced by GBE rather than quercetin in a dose- and time-dependent manner. Both GBE and quercetin increased the t-PA release significantly. Conclusion The effect of GBE on improving blood circulation may be partly attributed to its promoting TM expression and t-PA secretion by endothelial ceils, and quercetin participated in the effect of GBE on t-PA secretion. However, the action of GBE on increasing TM expression needs further study.

关键词： ginkgo biloba extract Quercetin Thrombomodulin Tissue-type plasminogen activator

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