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gilbert syndrome combined with prolonged jaundice caused by contrast agent:Case report

World Journal of Gastroenterology 2018年第13期24卷 1486-1490页

作者： Jian-Dan Qian Feng-Qin Hou Tai-Ling Wang Chen Shao Gui-Qiang Wang Department of Infectious Diseases and the Center for Liver Diseases Peking University First HospitalBeijing 100034China Department of Pathology China-Japan Friendship HospitalBeijing 100029China Department of Pathology Beijing YouAn Hospital Capital Medical UniversityBeijing 100069China The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Peking University International Hospital Beijing 102206China

This case highlights a patient with gilbert syndrome who underwent endoscopic retrograde cholangiopancreatography(ERCP) with removal of bile duct stones, who then experienced an unexplained increase in bilirubin, with total bilirubin(TBIL) levels increasing from 159.5 μmol/L to 396.2 μmol/L and to a maximum of 502.8 μmol/L after 9 d. Following the decrease in the TBIL level, enhanced magnetic resonance cholangiopancreatography(MRCP) was performed to exclude any possible remaining choledocholithiasis. Nevertheless, the serum bilirubin level increased again, with TBIL levels rising from 455.7 μmol/L to 594.8 μmol/L and a maximum level of 660.3 μmol/L with no remaining bile duct stones. A liver biopsy showed severe bile duct cholestasis with no inflammation. Based on the exclusion of other potential causes of hyperbilirubinemia and the fact that both instances of increased bilirubin occurred after ERCP and MRCP, the contrast agents iopromide and gadoterate meglumine were suspected to be the causes of the hyperbilirubinemia. As of the writing of this report, the patient's bilirubin levels have spontaneously returned to baseline levels. In summary,ERCP and MRCP utilizing the contrast agents iopromide and gadoterate meglumine may possibly induce prolonged hyperbilirubinemia.

关键词： Contrast agent Iopromide Gadoterate meglumine gilbert syndrome Jaundice

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Prevalence of gilbert Syndrome in Bangladesh

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Open Journal of Blood Diseases 2018年第1期8卷 1-9页

作者： Sanjana Zaman Hiroko Fukushima Ryoko Suzuki Mohammad Delwer Hossain Hawlader Shoji Yoshimatsu Yu Kanai Gias U. Ahsan Takashi Fukushima Department of Child Health Faculty of Medicine University of Tsukuba Tsukuba Japan Department of Public Health North South University Dhaka Bangladesh Department of Pediatrics University of Tsukuba Hospital Tsukuba Japan Department of Pediatrics National Hospital Organization Minami Kyoto Hospital Kyoto Japan

Background: gilbert syndrome (GS) is characterized by an elevated serum bil-irubin due to a polymorphism in Uridine Diphosphate Glucuronosyl Transferase (UGT1A1) gene. Several studies have found high prevalence of gilbert Syn-drome in some Asian countries but still haven’t explored in Bangladesh. Aim of this study was to determine the allele frequencies of two different variants of UGT1A1 polymorphisms (UGT1A1 6 and UGT1A1 28) among Bangladeshi population. Materials and method: Total 150 unrelated volunteer from outpa-tient unit of the Central Hospital Limited, and Bangabandhu Sheikh Mujib Medical University, Dhaka were enrolled in this study. Peripheral blood was obtained from each subject and DNA extraction was done by Genomic DNA Isolation Kit. Polymorphisms of UGT1A1*6 (c.211G>A) was genotyped using the TaqMan Assay-on-Demand SNP Typing System and UGT1A1*28 (c.-53_-52TA) promoter repeat number polymorphism was determined by PCR method on an ABI PRISM 3130 Genetic Analyzer. Results: 57.3% of the study participants were male, mean age of them was 4.05 years. Minor allele fre-quency (MAF) was 0.442 (44.2%) for UGT1A1*28 and 0.047 (4.7%) for UGT1A1*6. Conclusion: This is the first ever study conducted among Bangla-deshi population to identify the gilbert syndrome and found very high prevalence. Drugs those who are conjugated by UGT1A1 may lead to worse adverse event due to UGT1A1 polymorphism. Infants having decreased UGT1A1 enzyme activity develop neonatal jaundice and its further complication like Ker-nicterus. Higher incidence of gilbert syndrome among Bangladeshi might be the alert for the clinicians treating neonatal jaundice.

关键词： gilbert Syndrome Uridine Diphosphate Glucuronosyl Transferase

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第一跖背动脉gilbert分型的再理解

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中华显微外科杂志 2013年第3期36卷 209-210页

作者：侯致典王增涛钟世镇山东大学附属省立医院手足外科济南250021 南方医科大学临床解剖学研究所

本文探讨国内文献有关第一跖背动脉Gilber分型的翻译描述同原文的区别。侯致典等查阅国内相关专著、期刊文献中对第一跖背动脉gilbert分型的翻译描述及模式图，对照gilbert原文，比较国内文献同原文的差别。发现国内绝大多数文献对Gilb... 详细信息

本文探讨国内文献有关第一跖背动脉Gilber分型的翻译描述同原文的区别。侯致典等查阅国内相关专著、期刊文献中对第一跖背动脉gilbert分型的翻译描述及模式图，对照gilbert原文，比较国内文献同原文的差别。发现国内绝大多数文献对gilbert分型的文字翻译和示意图描述存在一些不准确甚至错误。本刊刊出此文，旨在讨论与争鸣，以更正对第一跖背动脉gilbert分型的认识，有利于国际交流及临床手术的开展。

关键词：第一跖背动脉 t分型 gilbert 国内文献期刊文献临床手术国际交流原文

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"I Am a Chinese with Black Skin"--Ugandan Vice President gilbert Bukenya

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Voice of Friendship 2004年第2期 39-40页

作者： Lin Yi

In November in Beijing it is already winter. People wearheavy coats. Chairs outside snack bars have been moved inside, and green plants can only be found in rooms with heating. But on the African continent, especially... 详细信息

关键词： gilbert winter continent lying Skin heating Africa

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两家5例gilbert综合征综合报告

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临床儿科杂志 1994年第5期12卷 314-315页

作者：董淑兰李文馨陈志红孙羽非刘令慧倪旭东宋颖云于学仁牛西安陕西省核工业四一七医院青岛医学院附属医院儿科陕西省核工业四一七医院 266003

家系1 先证者(Ⅲ)女,8岁。自幼间歇性巩膜、皮肤黄染。每次发作3～50天,多于发热时黄染加重,口服鲁米那后症状减轻。除黄疸外,无其他不适,大小便颜色正常。第1胎第1产,足月顺产,有生理性黄疸史,无肝炎接触史。父母非近亲结婚,其母孕期... 详细信息

家系1 先证者(Ⅲ)女,8岁。自幼间歇性巩膜、皮肤黄染。每次发作3～50天,多于发热时黄染加重,口服鲁米那后症状减轻。除黄疸外,无其他不适,大小便颜色正常。第1胎第1产,足月顺产,有生理性黄疸史,无肝炎接触史。父母非近亲结婚,其母孕期健康。体检:生长发育正常,巩膜及全身皮肤黄染。心肺(一),肝剑突下1cm,软,无压痛,肋下未触及。实验室检查:(1)黄疸期:黄疸指数15～35U,

关键词：未结合胆红素家系调查 gilbert 皮肤黄染血清总胆红素巩膜黄染综合征综合病症

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gilbert乘法器的三次非线性误差

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Journal of Semiconductors 1985年第6期 576-583页

作者：易明銧李青松北京市半导体器件研究所

本文利用双极型晶体管的Gummel-Poon模型,分析了gilbert乘法器的非线性误差,获得了三次误差的表达式.结果表明,gilbert乘法器的三次非线性误差起源于晶体管的基区电导调制效应.指出了三次非线性误差可以通过合理的电路和版图设计获得改... 详细信息

本文利用双极型晶体管的Gummel-Poon模型,分析了gilbert乘法器的非线性误差,获得了三次误差的表达式.结果表明,gilbert乘法器的三次非线性误差起源于晶体管的基区电导调制效应.指出了三次非线性误差可以通过合理的电路和版图设计获得改善.本文还进行了详细的实验论证,实验结果与理论分析一致.

关键词：双极型晶体管非线性误差电导调制效应三次非线性基区乘法器 gilbert

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gilbert综合征(附16例报告)

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实用内科杂志 1988年第6期 306-307页

作者：葛政举徐克成孟宪鏞南通医学院附属医院内科

gilbert综合征为体质性黄疸中最常见的一种,临床上甚易漏误诊。现将资料较完整的16例gilbert综合征分析如下,着重探讨其诊断问题。临床资料一、一般资料:男12例,女4例。起病年龄17～32岁,其中30岁2例。

关键词：高胆红素血症体质微绒毛光面内质网滑面内质网胆红质胆色素胆红素 gilbert 综合病症综合征

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gilbert综合征一例

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河北医药 1983年第5期 61-62页

作者：徐德义解放军408医院内一科

gilbert 综合征又称幼年间歇性黄疸或体质性肝功能不全、先天性非溶血性黄疸(游离胆红素增高型)我院曾收治一例,报告如下。患者男性、19岁、战士,住院号16358。患者在半个月前无明显原因出现乏力,食欲不振,但无(口恶)心,腹胀及两季肋部... 详细信息

gilbert 综合征又称幼年间歇性黄疸或体质性肝功能不全、先天性非溶血性黄疸(游离胆红素增高型)我院曾收治一例,报告如下。患者男性、19岁、战士,住院号16358。患者在半个月前无明显原因出现乏力,食欲不振,但无(口恶)心,腹胀及两季肋部疼痛。在本单位卫生所检查时发现皮肤巩膜轻度黄染、疑“急性黄疸型肝炎”送某医院,因未能确诊于1973年7月27日转入我院。既往体健,

关键词：游离胆红素非溶血性 gilbert 血清胆红素综合征综合病症

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