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genotype e:The neglected genotype of hepatitis B virus

World Journal of Hepatology 2021年第12期13卷 1875-1891页

作者： Luicer Anne Olubayo Ingasia Constance Wose Kinge Anna Kramvis Hepatitis Virus Diversity Research Unit Department of Internal MedicineSchool of Clinical MedicineFaculty of Health SciencesUniversity of the WitwatersrandJohannesburg 2193GautengSouth Africa Department of Implementation Science Right to CareJohannesburg 0046GautengSouth Africa

Hepatitis B virus(HBV)(sub)genotypes A1,D3 and e circulate in sub-Saharan Africa,the region with one of the highest incidences of HBV-associated hepatocellular carcinoma *** genotype e was identified more than 20 years ago,and is the most widespread genotype in Africa,it has not been extensively *** current knowledge status and gaps in its origin and evolution,natural history of infection,disease progression,response to antiviral therapy and vaccination are *** e is an African genotype,with unique molecular characteristics that is found mainly in Western and Central Africa and rarely outside Africa except in individuals of African *** low prevalence of this genotype in the African descendant populations in the New World,phylogeographic analyses,the low genetic diversity and evidence of remnants of genotype e in ancient HBV samples suggests the relatively recent reintroduction into the *** is scarcity of information on the clinical and virological characteristics of genotype e-infected patients,disease progression and outcomes and efficacy of anti-HBV *** infected with genotype e have been characterised with high hepatitis B e antigen-positivity and high viral load with a lower end of treatment response to interferon-alpha.A minority of genotype e-infected participants have been included in studies in which treatment response was *** concern is that current guidelines do not consider patients infected with genotype ***,there is an urgent need for further large-scale investigations into genotype e,the neglected genotype of HBV.

关键词： Hepatitis B virus genotype e evolution Clinical significance Antiviral therapy Vaccination

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