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genome biology: The Second Modern Synthesis

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Genomics,Proteomics & Bioinformatics 2005年第1期 11-12页

作者： Gane Ka-Shu Wong Beijing 101300 Beijing Genomics Institute China. Chinese Academy of Sciences

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Creating animal models, why not use the Chinese tree shrew ( Tupaia belangeri chinensis)？

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Zoological Research 2017年第3期38卷 118-126页

作者： Yong-Gang Yao Key Laboratory of Animal Models and Human Disease Mechanisms Kunming Institute of Zoology Chinese Academy of SciencesKunming Yunnan 650223 China Kunming Primate Research Center of the Chinese Academy of Sciences Kunming Institute of Zoology Chinese Academy of SciencesKunming Yunnan 650223 China

The Chinese tree shrew （Tupaia belangeri chinensis） a squirrel-like and rat-sized mammal, has a wide distribution in Southeast Asia, South and Southwest China and has many unique characteristics that make it suitable for use as an experimental animal. There have been many studies using the tree shrew （Tupaia belangeri） aimed at increasing our understanding of fundamental biological mechanisms and for the modeling of human diseases and therapeutic responses. The recent release of a publicly available annotated genome sequence of the Chinese tree shrew and its genome database （***） has offered a solid base from which it is possible to elucidate the basic biological properties and create animal models using this species. The extensive characterization of key factors and signaling pathways in the immune and nervous systems has shown that tree shrews possess both conserved and unique features relative to primates. Hitherto, the tree shrew has been successfully used to create animal models for myopia, depression, breast cancer, alcohol-induced or non-alcoholic fatty liver diseases, herpes simplex virus type 1 （HSV-1） and hepatitis C virus （HCV） infections, to name a few. The recent successful genetic manipulation of the tree shrew has opened a new avenue for the wider usage of this animal in biomedical research. In this opinion paper, I attempt to summarize the recent research advances that have used the Chinese tree shrew, with a focus on the new knowledge obtained by using the biological properties identified using the tree shrew genome, a proposal for the genome-based approach for creating animal models, and the genetic manipulation of the tree shrew. With more studies using this species and the application of cutting-edge gene editing techniques, the tree shrew will continue to be under the spot light as a viable animal model for investigating the basis of many different human diseases.

关键词： Chinese tree shrew genome biology Animal model Gene editing Innate immunity

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