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Molecular pathogenesis of lymphomas of mucosa-associated lymphoid tissue-from(auto)antigen driven selection to the activation of NF-_(k)B signaling

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Science China(Life Sciences) 2015年第12期58卷 1246-1255页

作者： ZHANG YiAn WEI Zheng LI Jing LIU Peng Department of Hematology Zhongshan Hospital Fudan University Shanghai 200032 China

Lymphomas of mucosa-associated lymphoid tissue(MALT) are typically present at sites such as the stomach, lung or urinary tract, where lymphoid tissues scatter in mucosa lamina propria, intra- or sub-epithelial cells. The infection of certain pathogens, such as Helicobacter pylori, Chlamydophila psittaci, Borrelia burgdorferi, hepatitis C virus, or certain autoantigens cause these sites to generate a germinal center called the "acquired lymphoid tissue". The molecular pathogenesis of MALT lymphoma is a multi-step process. Receptor signaling, such as the contact stimulation of B cell receptors and CD4 positive T cells mediated by CD40/CD40-ligand and T helper cell type 2 cytokines like interleukin-4, contributes to tumor cell proliferation. A number of genetic alterations have been identified in MALT lymphoma, and among them are important translocations, such as t(11;18)(q21;q21), t(1;14)(p22;q32), t(14;18)(q32;q21) and t(3;14)(p13;q32). Fusion proteins generated by these translocations share the same NF-?B signaling pathway, which is activated by the caspase activation and recruitment domain containing molecules of the membrane associated guanylate kinase family, B cell lymphoma-10 and MALT1(CBM) protein complex. They act downstream of cell surface receptors, such as B cell receptors, T cell receptors, B cell activating factors and Toll-like receptors, and participate in the biological process of MALT lymphoma. The discovery of therapeutic drugs that exclusively inhibit the antigen receptor signaling pathway will be beneficial for the treatment of B cell lymphomas in the future.

关键词： malt lymphoma helicobacter pylori chromosomal translocation genetic alteration NF-_(k)B

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Comprehensive Analysis of the Role of Forkhead Box J3(FOXJ3)in Human Cancers

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Wuhan University Journal of Natural Sciences 2024年第1期29卷 74-84页

作者： YANG Yang LI Yulong WANG Xiaoli School of Public Health Shaanxi University of Chinese MedicineXianyang 712046ShaanxiChina Department of Gastroenterology Shaanxi Provincial People's hospitalXi'an 710068ShaanxiChina Department of Dermatology Affiliated Hospital of Shaanxi University of Chinese MedicineXianyang 712000ShaanxiChina

Forkhead box J3(FOXJ3)is a member of the forkhead box(Fox)***,increasing evidence has revealed the relationship between Fox family members and ***3 is involved in various types of cancer,including lung cancer,tongue squamous carcinoma,and prostate cancer;however,a comprehensive pan-cancer analysis of FOXJ3 remains ***,we explored the function of FOXJ3 across cancers using online websites and databases including TIMER2.0,Sanger Box,UALCAN,GEPIA2.0,c Bio Portal,CancerSEA,STRING,Bio GRID and Metascape to analyze the role of FOXJ3 in *** expression of FOXJ3 was found in various *** genetic alteration percentage in tumors was determined,and elevated FOXJ3 expression was found to be associated with worse overall survival in brain lower grade glioma(LGG),liver hepatocellular carcinoma(LIHC),sarcoma(SARC)and thyroid *** FOXJ3 expression was related to worse prognosis with disease-free survival in adrenocortical carcinoma,LGG and ***3 expression was related to immune infiltration in several *** analysis showed that histone modification,the TGF-βsignaling pathway,and chromatin organization were the top three enriched ontology clusters of the top 100 similar genes of *** pancancer analysis provides comprehensive insights into FOXJ3 from the perspective of bioinformatics in different cancers,where it serves as a potential biomarker for prognosis,especially in LGG and ***3 is also correlated with immune infiltrates in certain human tumors.

关键词： FOXJ3 cancer genetic alteration prognosis

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Asian variant intravascular large B-cell lymphoma with highly suspected central nervous system involvement:A case report

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World Journal of Clinical Cases 2023年第33期11卷 8058-8064页

作者： Yong-Pyo Lee Seung-Myoung Son Jihyun Kwon Department of Internal Medicine Chungbuk National University HospitalCheongju 28644South Korea Department of Pathology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju 28644South Korea

BACKGROUND Intravascular large B-cell lymphoma(IVLBCL)is a rare subtype of extranodal *** particular,the Asian variant of IVLBCL is characterized by hemophagocytic lymphohistiocytosis along with bone marrow ***,central nervous system(CNS)involvement is uncommon in this variant compared to the Western ***,we report a case of typical Asian variant IVLBCL with highly suspected CNS involvement and discuss the nature of the disease and its genetic *** SUMMARY A 67-year-old female patient complained of gradually worsening cognitive *** hospitalized,she developed a high fever and showed marked *** imaging revealed a suspected leptomeningeal *** no malignant cells were found in the cerebrospinal fluid(CSF),the protein and lactate dehydrogenase levels in CSF were *** marrow examination revealed an increased number of hemophagocytic histiocytes,and 18F-fluorodeoxyglucose(FDG)positron emission tomography with computerized tomography scan revealed increased FDG uptake in both adrenal glands,the liver,and the right ethmoid sinus.A tissue biopsy showed atypical large lymphoid cells with prominent nucleoli in the vessels,and the tumor cells were positive for CD20,BCL2,BCL6,and IRF4/*** addition,targeted sequencing identified MYD88,TET2,and PIM1 ***,we diagnosed the patient with the Asian variant of IVLBCL with highly suspected CNS *** Suspicion of IVLBCL and immediate diagnosis lead to timely ***,careful CNS examination at diagnosis is recommended.

关键词： Intravascular large B-cell lymphoma Asian variant Hemophagocytic lymphohistiocytosis Central nervous system involvement genetic alteration Case report

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