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NRN1 and CAT Gene Polymorphisms, Complex Noise, and Lifestyles interactively Affect the Risk of Noise-induced Hearing Loss

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Biomedical and Environmental Sciences 2021年第9期34卷 705-718页

作者： LIU Shuang Yan SONG Wei Qin XIN Jia Rui LI Zheng LEI Song CHEN Ying Qi ZHAO Tian Yu WANG Hai Yan XU Liang Wen ZHANG Mei Bian HONG Yu YANG Lei Medical School Hangzhou Normal UniversityHangzhou 310000ZhejiangChina Ningbo Center for Disease Control and Prevention Ningbo 315700ZhejiangChina Central people's hospital of Zhanjiang Zhanjiang 524000ZhejiangChina Institute of Occupational Health and Radiation Protection Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310000ZhejiangChina

Objective The effects of interactions between genetic and environmental factors on the noise-induced hearing loss(NIHL)are still *** study aimed to assess interactions among gene polymorphisms,noise metrics,and lifestyles on the risk of *** A case-control study was conducted using 307 patients with NIHL and 307 matched healthy individuals from five manufacturing *** demographic data,lifestyle details,and noise exposure levels were *** Kompetitive allele-specific polymerase chain reaction(KASP)was used to analyze the genotypes of 18 *** GMDR model demonstrated a relevant interaction between NRN1 rs3805789 and CAT rs7943316(P=0.0107).Subjects with T allele of rs3805789 or T allele of rs7943316 had higher risks of NIHL than those with the SNP pair of rs3805789-CC and rs7943316-AA(P<0.05).There was an interaction among rs3805789,rs7943316,and kurtosis(P=0.0010).Subjects exposed to complex noise and carrying both rs3805789-CT and rs7943316-TT or rs3805789-CT/TT and rs7943316-AA had higher risks of NIHL than those exposed to steady noise and carrying both rs3805789-CC and rs7943316-AA(P<0.05).The best six-locus model involving NRN1 rs3805789,CAT rs7943316,smoking,video volume,physical exercise,and working pressure for the risk of NIHL was found to be the interaction(P=0.0010).An interaction was also found among smoking,video volume,physical exercise,working pressure,and kurtosis(P=0.0107).Conclusion Concurrence of NRN1 and CAT constitutes a genetic risk factor for *** noise exposure significantly increases the risk of NIHL in subjects with a high genetic risk *** between genes and lifestyles as well as noise metrics and lifestyles affect the risk of NIHL.

关键词： Noise-induced hearing loss Kurtosis CAT NRN1 Lifestyle Interaction generalized multifactor dimensionality reduction

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