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Cancer cell membrane camouflaged biomimetic gelatin-based nanogel for tumor inhibition

Chinese Chemical Letters 2024年第11期35卷 389-394页

作者： Yuanzheng Wang Chen Zhang Shuyan Han Xiaoli Kong Changyun Quan Jun Wu Wei Zhang Department of Orthopedics Guizhou Provincial People's HospitalGuiyang 550000China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments(Sun Yat-sen University) School of Biomedical EngineeringSun Yat-sen UniversityGuangzhou 510006China Department of Nephrology Center of Kidney and UrologyThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong Kong SAR 999077China Department of Outpatient The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China

Enhancing the active tumor targeting ability and decreasing the clearance of reticuloendothelial system(RES)are important issues for drug delivery systems(DDSs)in cancer *** recent years,cell membrane camouflage,as one of the biomimetic modification strategies,has shown huge *** natural properties of source cells can be inherited,allowing the DDSs to successfully avoid phagocytosis by macrophages,prolong circulation time,and achieve homologous targeting to lesion *** this study,a cancer cell membrane camouflaged nanoplatform based on gelatin with a typical core-shell structure was developed for cancer ***(DOX)loaded gelatin nanogel(NG@DOX)acted as the inner core,and 4T1(mouse breast carcinoma cell)membrane was set as the outer shell(M-NG@DOX).The M-NG platform enhanced the ability of homologous targeting due to the surface protein of cell membrane being completely retained,which could promote the cell uptake of homotypic cells,avoid phagocytosis by RAW264.7 macrophages,and therefore increase accumulation in tumor ***,due to the better controlled drug release capability of M-NG@DOX,premature release of DOX in circulation could be reduced,minimizing side effects in common *** a result,the biomimetic nanoplatform in this study,obtained by a cancer cell membrane camouflaged drug delivery system,efficiently reached desirable tumor elimination,providing a significant strategy for effective targeted therapy and specific carcinoma therapy.

关键词： Cell membrane camouflage Biomimetic gelatin nanogel Drug delivery Tumor therapy

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