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Metabonomic analysis of plasma biochemical changes in pyrexia rats after treatment with gegenqinlian decoction,aspirin and itraconazole by UHPLC-FT-ICR-MS

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Journal of Pharmaceutical Analysis 2020年第6期10卷 581-587页

作者： Ting Liu Ruiyun Li Yue Cui Zhiguo Yu Yunli Zhao School of Pharmacy Shenyang Pharmaceutical UniversityShenyang110016China School of Pharmacy Shenyang Medical CollegeShenyang110034China

A metabonomic approach involving an ultrahigh-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry(UHPLC-FT-ICR-MS)was used to investigate the changes in the endogenous metabolites in the plasma of rats with yeast-induced pyrexia treated with gegenqinlian decoction(GQLD),aspirin and *** differences in the small molecule profiles of treatment using traditional Chinese medicine,etiological treatment and symptomatic treatment were ***-six plasma metabolites were identified or putatively identified,and the effects of the three medicines on the thirty-six metabolites were *** metabolic pathways indicated that GQLD,aspirin and itraconazole ameliorated the rats with yeast-induced pyrexia predominantly by regulating the metabolisms of phospholipid,sphingolipid,fatty acid oxidation,fatty acid amides,amino acid and glycerolipid in *** pharmacodynamics and metabonomic results showed that the three medicines exhibited the therapeutic effects on pyrexia by regulating the perturbations of multiple *** study provided a scientific basis for an in-depth understanding of the therapeutic effects of GQLD,aspirin and itraconazole on rats with yeast-induced pyrexia.

关键词： gegenqinlian decoction Aspirin Itraconazole Pyrexia UHPLC-FT-ICR-MS Metabonomic

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The Effect and Mechanism of gegenqinlian decoction to Myocardial Ischemia Reperfusionlnduced Arrhythmia

The Effect and Mechanism of Gegenqinlian Decoction to Myocar...

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安徽省药理学会2012年学术年会

作者： Jie Yang Zi-jiang Long Lei Mu Ming Chen Cheng-chen Wei Bo-chun Ding Pharmacology school Anhui University of Traditional Chinese Medicine

Objective To Study the effect and mechanism of gegenqinlian decoction to myocardial ischemia reperfusion induced arrhythmia model role of rats,to provide experimental evidence for clinical *** To divided the health SD rats into six groups,there were 10 rats in each group,Sham operation group(equal capacity distilled water),Model group(equal capacity distilled water),The Wenxinkeli group(2.43g·kg-1),gegenqinlian decoction high dose(8.64g crude drug·kg-1),medium dose(4.32g crude drug·kg-1),low dose(2.16g crude drug·kg-1) *** the Sham operation group,the other groups were performed by liquating anterior interventricular branch of the left desending coronary artery rat to establish myocardial ischemia reperfusion induced arrhythmia model role of rats,after the administration of continuous 7 days, electrocardiogram of leadⅡwas examined on the myocardial ischemia-reperfusion model. Postoperative were determined by spectrophotometry myocardial tissue of Na+-K+-ATP enzyme (Na+-K+-ATPase),Ca2+-ATP enzyme(Ca2+-ATPase)activity and serum superoxide dismutase (SOD),malondialdehyde(MDA) *** gegenqinlian decoction can significantly reduce the incidence of arrhythmia,serum MDA and increase serum SOD,also can significantly increase Na+-K+-ATPase,Ca2+-ATPase activity(Pgegenqinlian decoction has good resistance to laboratory arrhythmia role in the way of increasing enzymes activity and removing oxygen free radicals,to improve arrhythmia role and protect the ischemic myocardium

关键词： gegenqinlian decoction the anti-arrythmic myocardial ischemia reperfusion

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