检索结果-南通市图书馆

gegen qinlian decoction enhances immunity and protects intestinal barrier function in colorectal cancer patients via gut microbiota

引用

World Journal of Gastroenterology 2020年第48期26卷 7633-7651页

作者： Yang Li Zhong-Xin Li Chen-Yang Xie Jing Fan Ji Lv Xin-Jian Xu Jian Lv Wen-Tao Kuai Yi-Tao Jia Department of Oncology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina Department of Oncology Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Second Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Surgery The First Hospital of QinhuangdaoQinhuangdao 066000Hebei ProvinceChina Department of Thoracic Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Emergency Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND We previously showed,using the Traditional Chinese Medicine System Pharmacology Database,that gegen qinlian decoction(GQD)had a direct antitumor effect,and was combined with programmed cell death protein(PD)-1 inhibitors to treat microsatellite stable(MSS)tumor-bearing ***,the effect of GQD on patients with colorectal cancer(CRC)is not *** To determine the therapeutic mechanism of GQD in improving immune function,reducing inflammation and protecting intestinal barrier *** Seventy patients with CRC were included in this study:37 in the control group and 33 in the treatment *** proportions of CD4+T,CD8+T,natural killer(NK),NKT and T regulatory cells were measured by flow *** of the cytokines tumor necrosis factor(TNF)-α,interferon(IFN)-γ,interleukin(IL)-2,IL-6,IL-10 and serotonin(5-hydroxytryptamine;5-HT)in serum were assessed by enzyme-linked immunosorbent assay(ELISA).The expression of zonula occludens(ZO)-1,occludin,nuclear factor(NF)-κB and TNF-αin tumor and normal tissues was measured by *** composition of gut microbiota from patients in the treatment group was assessed using 16S rDNA *** There were no adverse events in the treatment *** proportion of CD4+T cells and NKT cells in the post-treatment group was significantly higher than that in the pre-treatment and control groups(P<0.05).The level of TNF-αin the posttreatment group was significantly lower than that in the pre-treatment and control groups(P<0.05).The concentration of 5-HT in the post-treatment group was significantly lower than that in the pre-treatment group(P<0.05).The expression of ZO-1 and occludin in tumor tissues in the treatment group was significantly higher than that in the control group(P<0.05).The expression of ZO-1 in normal tissues of the treatment group was significantly higher than that in the control group(P=0.010).Compared with the control group,expression of NF-κB and TNF-αin tumor tis

关键词： Colorectal cancer gegen qinlian decoction Immunity Inflammation Intestinal barrier function Gut microbiota

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antidiabetic Effects of gegen qinlian decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine

引用

Genomics, Proteomics & Bioinformatics 2020年第6期18卷 721-736页

作者： Xizhan Xu Zezheng Gao Fuquan Yang Yingying Yang Liang Chen Lin Han Na Zhao Jiayue Xu Xinmiao Wang Yue Ma Lian Shu Xiaoxi Hu Na Lyu Yuanlong Pan Baoli Zhu Linhua Zhao Xiaolin Tong Jun Wang CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Endocrinology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Beijing University of Chinese Medicine Beijing 100029China Laboratory of Protein and Peptide Pharmaceuticals&Laboratory of Proteomics Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Shenzhen Hospital Guangzhou University of Chinese MedicineShenzhen 518034China

gegen qinlian decoction(GQD),a traditional Chinese medicine(TCM)formula,has long been used for the treatment of common metabolic diseases,including type 2 diabetes ***,the main limitation of its wider application is ingredient complexity of this ***,it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its ***,we compared the effects of GQD and berberine,a hypothetical key active pharmaceutical ingredient of GQD,on a diabetic rat model by comprehensive analyses of gut microbiota,short-chain fatty acids,proinflammatory cytokines,and ileum *** results show that berberine and GQD had similar effects on lowering blood glucose levels,modulating gut microbiota,inducing ileal gene expression,as well as relieving systemic and local *** expected,both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria,including Faecalibacterium and Roseburia,thereby attenuating intestinal inflammation and lowering *** of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or ***,concentration of serum proinflammatory cytokines and expression of immune-related genes,including Nfkb1,Stat1,and Ifnrg1,in pancreatic islets were significantly reduced after *** study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut *** strategy employed would facilitate further standardization and widespread application of TCM in many diseases.

关键词： Gut microbiota Type 2 diabetes mellitus Traditional Chinese medicine Berberine gegen qinlian decoction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Administration of modified gegen qinlian decoction for hemorrhagic chronic radiation proctitis: A case report and review of literature

引用

World Journal of Clinical Cases 2023年第5期11卷 1129-1136页

作者： Shao-Yong Liu Liu-Ling Hu Shi-Jun Wang Zhong-Li Liao Traditional Chinese Medicine Cancer Treatment Center Chongqing University Cancer HospitalChongqing 400030China The Center for Gastroenterology Diagnosis and Minimally Invasive Treatment of Early Gastrointestinal CancerChongqing University Cancer HospitalChongqing 400030China

BACKGROUND Hemorrhagic chronic radiation proctitis(CRP) is a common late complication of irradiation of the pelvis and seriously impairs life quality. There is no standard treatment for hemorrhagic CRP. Medical treatment, interventional treatment, and surgery are available, but they are limited in their applications due to nondefinite efficacy or side effects. Chinese herbal medicine(CHM), as a complementary or alternative therapy, may provide another option for hemorrhagic CRP *** SUMMARY A 51-year-old woman with cervical cancer received intensity-modulated radiation therapy and brachytherapy with a total dose of 93 Gy fifteen days after hysterectomy and bilateral adnexectomy. She received six additional cycles of chemotherapy with carboplatin and paclitaxel. Nine months after radiotherapy treatment, she mainly complained of 5-6 times diarrhea daily and bloody purulent stools for over 10 d. After colonoscopy examinations, she was diagnosed with hemorrhagic CRP with a giant ulcer. After assessment, she received CHM treatment. The specific regimen was 150 mL of modified gegen qinlian decoction(GQD) used as a retention enema for 1 mo, followed by replacement with oral administration of 150 mL of modified GQD three times per day for 5 mo. After the whole treatment, her diarrhea reduced to 1-2 times a day. Her rectal tenesmus and mild pain in lower abdomen disappeared. Both colonoscopy and magnetic resonance imaging confirmed its significant improvement. During treatment,there were no side effects, such as liver and renal function *** Modified GQD may be another effective and safe option for hemorrhagic CRP patients with giant ulcers.

关键词： Hemorrhagic chronic radiation proctitis Chinese herbal medicine gegen qinlian decoction Retention enema Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Double-blinded,randomized clinical trial of gegen qinlian decoction pinpoints Faecalibacterium as key gut bacteria in alleviating hyperglycemia

引用

Precision Clinical Medicine 2024年第1期7卷 21-33页

作者： Zezheng Gao Wenhui Zhang Lisha He Han Wang Yufei Li Xiaotian Jiang Sha DI Xinmiao Wang Xuan Zhang Lin Han Yanwen Liu Chengjuan Gu Mengyi Wu Xinhui He Lei Cheng Jun Wang Xiaolin Tong Linhua Zhao Institute of Metabolic Diseases Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Department of Endocrinology Guang anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Chengdu University of Traditional Chinese Medicine Chengdu 611137China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China Centre for Evidence-Based Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Department of Endocrinology Affiliated Hospital of Changchun University of Chinese MedicineChangchun 13000oChina Biologicals Science and Technology Institute Baotou Teacher's CollegeBaotou 014030China Department of Endocrinology Zhengzhou T.C.M.HospitalZhengzhou 450007China Shenzhen Hospital Guangzhou University of Chinese Medicine(Futian)Shenzhen 518000China Department of Cardiology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Cardiology Yunnan Provincial Hospital of Traditional Chinese MedicineKunming 650000China Key Laboratory of Development and Application of Rural Renewable Energy Biogas Institute of Ministry of Agriculture and Rural AffairsChengdu 610041China

Background:Accumulating evidence suggests that metabolic disorders,including type 2 diabetes mellitus(T2DM),can be treated with traditional Chinese medicine formulas,such as the gegen qinlian decoction(GQD).This study elucidates the mechanisms by which gut microbes mediate the anti-diabetic effects of ***:We conducted a double-blind randomized clinical trial involving 120 untreated participants with *** the 12-week intervention,anthropometric measurements and diabetic traits were recorded every 4 *** microbiota and serum metabolites were measured before and after the intervention using 16S rDNA sequencing,liquid chromatography-mass spectrometry,and Bio-Plex ***:Anti-diabetic effects were observed in the GQD group in the human ***,glycated hemoglobin,fasting plasma glucose,and two-hour postprandial blood glucose levels were significantly lower in the GQD group than in the placebo ***,Faecalibacterium was significantly enriched in the GQD group,and the short-chain fatty acid levels were higher and the serum inflammation-associated marker levels were lower in the GQD group compared to the placebo ***,Faecalibacterium abundance negatively correlated with the levels of serum hemoglobin,fasting plasma glucose,and pro-inflammatory ***,the diabetes-alleviating effect of Faecalibacterium was confirmed by oral administration of Faecalibacterium prausnitzi(DSMZ 17677)in ***:GQD improved type 2 diabetes primarily by modulating the abundance of Faecalibacterium in the gut microbiota,alleviating metabolic disorders and the inflammatory state.

关键词： double-blinded randomized controlled trial type 2 diabetes mellitus gegen qinlian decoction Faecalibacterium metabolic disorders inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Puerarin on the Pharmacokinetics of Baicalin in gegen qinlian decoction (葛根芩连汤) in Mice

引用

Chinese Journal of Integrative Medicine 2018年第7期24卷 525-530页

作者： KONG Hui WANG Xue-qian WANG Qing-guo ZHAO Yan SUN Ye ZHANG Yue XU Jie-kun QU Hui-hua School of Preclinical Medicine Beijing University of Chinese Medicine Center of Scientific Experiment Beijing University of Chinese Medicine

Objective： To study the pharmacokinetics of puerarin（PUE） in gegen qinlian decoction（葛根芩连汤, GQD）, and the effects of PUE dosage variations on the pharmacokinetics of baicalin（BAL） in mice. Methods： GQD is composed of the concentrated granules of four Chinese herbs. Three dosages with different levels of PUE, including GQD, GQD co-administered with PUE, and GQD co-administration with two times the amount of PUE, were used to research the pharmacokinetics of PUE and BAL in mice. The indirect competitive enzyme-linked immunosorbent assay（ic ELISA） methods based on an anti PUE-monoclonal antibody（MAb） and BAL-MAb were employed to determine the concentration of PUE and BAL in mice blood. Results： After the co-administration of GQD with PUE, the area under the curves（AUC0-14 h） of PUE increased 2.8 times compared with GQD. At the dose of GQD co-administration at two times that of PUE, the AUC0-14 h of PUE was almost equal to that of GQD co-administration of PUE, showing non-linear pharmacokinetics. The AUC0-48 h of BAL showed a good dose-related increase of PUE（r=0.993） in the range from 100 to 300 mg/kg, indicating that PUE dramatically affects the absorption of BAL in mice. There was no significant difference in the other pharmacokinetic parameters, such as the first time of maximum concentration（Tmax）, the second Tmax, or the mean residence time. Conclusions： The ic ELISA methods were successfully applied to pharmacokinetic studies of PUE and BAL in GQD in mice. The dosage variability of PUE of the main ingredient in GQD affects its own pharmacokinetic characteristics and the absorption characteristics of BAL.

关键词： pharmacokinetics gegen qinlian decoction indirect competitive enzyme-linked immunosorbent assay puerarin baicalin Chinese medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The potential role of gegen qinlian decoction in the treatment of coronavirus disease 2019 based on network pharmacology and validation of lipopolysaccharide-induced macrophages

引用

Integrative Medicine Discovery 2024年第24期8卷 1-8页

作者： Lei Wang Ling-Yun Wang Li Zhong Jian-Feng Shi Xiao-Ming Yao Wan-Wei Yang Department of Clinical Laboratory Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese medicineJiangsu Province Academy of Traditional Chinese MedicineNanjing 210028China

Background:Coronavirus disease 2019(COVID-19)is caused by severe acute respiratory syndrome coronavirus 2,which has led to deaths and currently lacks an efficient *** studies suggesting the potential of the gegen qinlian decoction(GQD)in preventing COVID-19,comprehensive analyses of its anti-COVID-19 potential are still ***:GQD treatment was evaluated for its efficacy in ameliorating the early stage(24 hours)of lipopolysaccharide(LPS)-induced cytokine storm in ***,target genes of GQD were co-analyzed with COVID-19 signature genes to identify key ingredients and their *** was also conducted using an LPS-induced macrophage ***:GQD treatment effectively ameliorated the early stage of LPS-induced cytokine storm in *** ingredients such as quercetin were found to be involved in multiple pathways,including inflammation,immunity,oxidative stress,cell proliferation,and apoptosis,through the AGE-RAGE signaling pathway and IL-17 signaling *** the LPS-induced macrophage model,quercetin inhibited macrophage polarization(M1)and the secretion of inflammatory factors(IL-6,TNF-α,IL-17A).Conclusions:Our results indicate that GQD can be utilized in the treatment of cytokine storm induced by COVID-19 and has the potential to treat COVID-19 by suppressing the COVID-19 signature genes and macrophage polarization.

关键词： gegen qinlian decoction coronavirus disease 2019 network pharmacology macrophage polarization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mechanism of gegen qinlian decoction in Treating Type 2 Diabetes Mellitus Complicated with NAFLD Based on Network Pharmacology

引用

Medicinal Plant 2024年第4期15卷 11-15页

作者： Yujia HUANG Xiaoyi HUANG Xinyu XU Qianqian QIN Yasi NONG Yanyang LI Wenyong FENG Chunxiu YIN Kang LUO Xin XIE Xiaojin HUANG Suoyi HUANG Juan ZHONG College of Clinical Medicine Youjiang Medical University for NationalitiesBaise 533000China College of Basic Medicine Youjiang Medical University for NationalitiesBaise 533000China College of Public Health and Management Youjiang Medical University for NationalitiesBaise 533000China College of Pharmacy Youjiang Medical University for NationalitiesBaise 533000China Key Laboratory of China's Colleges for the Study of Characteristic Ethnic Medicine in Youjiang River Basin Baise 533000China College of Life Sciences Youjiang Medical University for NationalitiesBaise 533000China

[Objectives]To explore the mechanism of gegen qinlian decoction in treating type 2 diabetes mellitus(T2DM)complicated with non-alcoholic fatty liver disease(NAFLD)by analyzing the effective components of gegen qinlian decoction.[Methods]TCMSP database was used to analyze the active components of gegen qinlian decoction,and pubchem and Swiss ADME databases were also used to predict drug targets,extract T2DM complicated with NAFLD targets from OMIM and Genecards *** plot was drawn to obtain intersection targets,and finally Cytoscape was used to make core target maps and drug-target-disease network *** DAVID and Metascape database to analyze the intersection targets,the gene ontology information of Go and KEGG was *** informatics technology was used to visualize GO,and Cytoscape was used to make drug-target-disease network map-enrichment pathway map.[Results]The network pharmacological analysis showed that gegen qinlian decoction acted on the key targets of type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease,such as ALB and ALT1,through many components,and achieved the purpose of treating this *** chemical constituents of the drug include formononetin,5-hydroxyisomucronulatol-2,5-2-O-glucoside,cholesteryl laurate,isoliquiritigenin,etc.[Conclusions]This study provides a new idea and theoretical support for future drug research and clinical practice.

关键词： gegen qinlian decoction Type 2 diabetes mellitus complicated by non-alcoholic fatty liver disease Network pharmacology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical Effect of Modified gegen qinlian decoction Combined with Western Medicine on Children with Rotavirus Enteritis with Damp-Heat Syndrome

引用

Medicinal Plant 2024年第6期15卷 66-69,72页

作者： Jingrui DOU Huahua ZHANG Haiya HAO Ying YANG Xi'an Daxing Hospital Xi'an 710016China Gaoling Maternal and Child Health Hospital Xi'an 710200China The Second Affiliated Hospital of Shaanxi University of Chinese Medicine Xi'an 710003China

[Objectives]To explore the clinical effect of Modified gegen qinlian decoction combined with western medicine on children with rotavirus enteritis with damp-heat syndrome and its influence on myocardial enzymes.[Methods]One hundred and eighty children with rotavirus enteritis with damp-heat syndrome were randomly divided into control group and observation group,with 90 cases in each *** control group was given western medicine symptomatic treatment,and the observation group was given Modified gegen qinlian decoction treatment on the basis of the control *** groups were treated for 5 *** clinical efficacy,symptom disappearance time,myocardial zymogram indicator level and TCM syndrome scores were compared between the two groups.[Results]After 5 d of treatment,the total effective rate of the observation group was 94.44%,which was significantly higher than that of the control group(84.44%)(Pgegen qinlian decoction combined with western medicine can quickly relieve t

关键词： Rotavirus enteritis Children Damp-heat syndrome gegen qinlian decoction Myocardial zymogram TCM syndrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Processed Research about gegen qinlian decoction to Vascular Protection of Arrhythmias in Rats

Processed Research about Gegen Qinlian Decoction to Vascular...

引用

安徽省药理学会2012年学术年会

作者： Lei Mu Zi-jiang Long Jie Yong Ming Chen Cheng-chen Wei Bo-chun Ding Department of pharmacology Anhui College of Traditional Chinese Medicine

Objective Observe gegen qinlian decoction to vascular protection of arrhythmia in *** Ligating the left anterior descending artery of the rat and then detecting limbⅡECG by injury model of myocardial ischemia 30min and reperfusion 15min in *** the operation,postoperative radioimmunoassay is used to detect the content of plasma endothelin(ET) and angiotensinⅡ(AngⅡ);the tumor necrosis factor-α(TNF-α) of serum and the nuclear factor-κB(NF-κB) of myocardial tissue are measured by using *** Compared with the sham operation group,increased AngⅡ、TNF-αand NF-κB expressions are found in model group rats after reperfusion(Pgegenqinlian decoction can significantly reduce reperfusion arrhythmia score(Pgegen qinlian decoction group(Pgegen qinlian decoction has a certain protective effect against reperfusion induced arrhythmia,which is related to reducing the content of AngⅡand then suppressing the expression of NF-κB、TNF-α、ET in infarcted reflow.

关键词： gegen qinlian decoction Myocardial ischemia and reperfiision Arrhythmia ET Angll TNF-α NF-κB

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

The Antipyretic and Bacteriostatic Action of gegen Qinlan decoction and Its Effects of Immune Function

引用

Military Medical Research 1987年第2期 158-161页

作者：佟丽黄添友许俊杰 Department of Traditional Chinese Medicine The First Medical College of PLA Guangzhou

The pharmacological effect about the recipe of ancient Chinesemedicine and herb drugs—gegen qinlian decoction(GGQLD)was *** results showed that it could markedly lower the body temperature of feverishrabbits caused by infection of *** effect is as strong as that ofAspirin compound(APC),there is no statistical significance between animaltreated by GGQLD and those by *** could also inhibit the growth of manykinds of bacteria(Staphylococcus;Bacillus dysenteriae;Pneumococcus)in vivoand in *** was observed that the percentage of ANAE~+ lymphocytes in thespleen and lymphonodes and the number of PFC in the spleen of mouse could beincreased by ***,the phagocytic effect of peritoneal macrophagesin mice treated by GGQLD was strengthened,which suggested that the antifebrileand antibiotic effects of this medicine are partly related to its efficiency to enhancethe immunity against pathogens.

关键词： gegen qinlian decoction antipyresis antibiotic effect immunity

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：