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Magnetic resonance imaging of the pancreas in streptozotocin-induced diabetic rats: Gadofluorine P and gd-dota

World Journal of Gastroenterology 2015年第19期21卷 5831-5842页

作者： Hye Rim Cho Youkyung Lee Philip Doble David Bishop Dominic Hare Young-Jae Kim Kwang Gi Kim Hye Seung Jung Kyong Soo Park Seung Hong Choi Woo Kyung Moon Department of Radiology Seoul National University College of Medicine Department of Radiation Applied Life Science Seoul National University College of Medicine Department of Radiology College of MedicineHanyang University Hanyang University Guri Hospital Guri Department of Chemistry and Forensic Science University of TechnologySydney Biomedical Engineering Branch Division of Convergence Technology National Cancer Center Department of Internal Medicine Seoul NationalUniversity College of Medicine Center for Nanoparticle Research Institute for Basic Science and School of Chemical and Biological Engineering Seoul National University

AIM: To investigate the performance of Gadofluorine P-enhanced magnetic resonance imaging(MRI) on the diagnosis of diabetes in a streptozotocin(STZ)-induced diabetic rat model.METHODS: Fischer 344 rats were treated with STZ.Rats not treated with STZ served as controls. T1-weighted MRI was performed using a 3T scanner before and after the injection of gd-dota or Gadofluorine P(6 diabetic rats, 5 controls). The normalized signal intensity(SI) and the enhancement ratio(ER) of the pancreas were measured at each time point, and the values were compared between the normal and diabetic rats using the Mann-Whitney test. In addition,the values were correlated with the mean islet number.Optimal cut-off values were calculated using a positive test based on receiver operating characteristics.Intrapancreatic gd concentration after the injection of each contrast media was measured using laser ablation-inductively coupled plasma-mass spectrometry in a separate set of rats(4 diabetic rats, 4 controls for Gadofluorine P; 2, 2 for gd-dota).RESULTS: The normalized SI and ER of the pancreas using gd-dota were not significantly different between diabetic rats and controls. With Gadofluorine P, the values were significantly higher in the diabetic rats than in the control rats 30 min after injection(P gd-dota(0.967 vs 0.667, P = 0.085). An increase in normalized SI 30 min after Gadofluorine P was correlated with a decrease in the mean number of islets(r 2 = 0.510, P = 0.014). Intra-pancreatic gd was higher in rats with Gadofluorine P injection than gd-dota injection(Gadofluorine P vs gd-dota, 7.37 vs 0.00, P gd was observed between the control and diabetic animals that were sacrificed 30 min after Gadofluorine P injection(control vs diabetic, 3.25 ng/g vs 10.55 ng/g, P < 0.05)CONCLUSION: In this STZ-i

关键词： Gadofluorine P gd-dota Magnetic resonancecontrast media Type 1 diabetes Pancreas

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镰状细胞性贫血儿童疼痛性骨危象的gd-dota增强MRI

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国际医学放射学杂志 1995年第5期 309-309页

作者：周辅昔王绍武

为评价gd-dota增强MRI在处理镰状细胞性贫血儿童疼痛性骨危象(painful osseous crises)中的作用,作者在9例患儿的11次骨危象中做了MRI、核素骨扫描和超声检查。每一病人的骨危象病因由临床医师根据患者病程、对抗生素治疗的反应和手术... 详细信息

为评价gd-dota增强MRI在处理镰状细胞性贫血儿童疼痛性骨危象(painful osseous crises)中的作用,作者在9例患儿的11次骨危象中做了MRI、核素骨扫描和超声检查。每一病人的骨危象病因由临床医师根据患者病程、对抗生素治疗的反应和手术标本的细菌学检查作出最终诊断,结果符合急性

关键词： MRI 镰状细胞性贫血 gd-dota 疼痛性危象儿童

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在短、宽口径,1.5T系统中的全身增强MR血管成像:gd-BOPTA和gd-dota的个体对照

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国际医学放射学杂志 2008年第A6期31卷 525-525页

作者： M.Rasmus J.Bremerich T.Egelhof R.W.Huegli G.Bongartz D.Bilecen 王东烨 Department of Radiology University Hospital Basel Petersgraben 4 4031 Basel Switzerland.

全身增强磁共振血管成像(CE-MRA)"一站式"扫描能够提供全部循环系统的信息。短、宽口径扫描仪可能因Z轴视野受限而还未能应用于全身CE-MRA。

关键词： MR血管成像 gd-Bopta gd-dota 对比增强全身血管成像

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