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Clinical characteristics,gastrointestinal manifestations and outcomes of COVID-19 patients in Iran;does the location matters?

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World Journal of Clinical Cases 2021年第18期9卷 4654-4667页

作者： Pooneh Mokarram Maryam Mehdipour Dalivand Antonio Pizuorno Farnaz Aligolighasemabadi Mohammadamin Sadeghdoust Ebtesam Sadeghdoust Farshad Aduli Gholamreza Oskrochi Hassan Brim Hassan Ashktorab Autophagy Research Center Department of BiochemistryShiraz University of Medical SciencesShiraz 71348Iran Department of Medicine Howard UniversityWashingtonDC 20060United States Department of Medicine La Universidad del ZuliaFaculty of MedicineMaracaibo 4002Venezuela Department of Internal Medicine Mashhad Medical Sciences BranchIslamic Azad UniversityMashhad 13131Iran Department of Internal Medicine School of MedicineDezful University of Medical SciencesDezful 64616Iran Collage of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait

BACKGROUND Coronavirus disease 2019(COVID-19)started in Asia,and Iran was one of its first *** To study the gastrointestinal(GI)symptoms and comorbidities associated with this pandemic in four different regions of *** We analyzed data from severe acute respiratory syndrome coronavirus 2 positive patients evaluated at four hospitals of Iran(n=91),including South(Shiraz),Southeast(Dezful),Rasht(North),and Northwest(Mashhad)between April and September ***,comorbidities and clinical findings including GI symptoms were *** descriptive analysis and correlation analyses of symptoms,comorbidities,and mortality were *** The average age of COVID-19 patients was 51.1 years,and 56%were *** rate was 17%.Cough with 84.6%,shortness of breath with 71.4%,fever with 52.7%,and loss of appetite with 43.9%were the main *** cardiac disease was the most common comorbidity with an average of 28.5%followed by hypertension(28.5%)and diabetes(25.2%).The highest comorbidity in North(Rasht)was diabetes(30%)and in South(Dezful)hypertension(37%).Shiraz leads cardiac disease with 43.4%.The most reported GI symptoms included nausea,diarrhea,vomiting,and abdominal pain,with 42.8%,31.8%,26.8%,and 12%prevalence,*** addition,albumin,alkaline phosphatase,aspartate aminotransferase,and alanine aminotransferase were elevated in 26.3%.CONCLUSION Our results show hypertension and diabetes as the most common comorbidities,but their distribution was different in COVID-19 patients in the four studied regions of ***,diarrhea,and elevated liver enzymes were the most common GI *** was also a high mortality rate that was associated with high infection rates in Iran at the beginning of the pandemic.

关键词： COVID-19 Pandemic gastrointestinal manifestation Iran

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