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Medical therapy for advanced gastro-entero-pancreatic and bronchopulmonary neuroendocrine tumors

Journal of Cancer Metastasis and Treatment 2016年第1期2卷 329-340页

作者： Mariangela Torniai Silvia Rinaldi Francesca Morgese Giulia Ricci Azzurra Onofri Christian Grohé Rossana Berardi Department of Medical Oncology UniversitàPolitecnica delle Marche60100 AnconaItaly Department of Respiratory Diseases Ev.Lungenklinik BerlinUniversitätsmedizin ChariteLindenberger Weg 2713125 BerlinGermany

neuroendocrine tumors(NETs)represent a spectrum of rare neoplasms arising in different organism *** on the site of onset,they also can be distinguished using lab exams(secreting ***),clinical symptoms(functioning ***),behavioral,morphological characteristics(tumor cells’architectural growth patterns,mitotic and Ki-67 index,presence of necrosis),and grade of cellular *** aim of this review is to focus on the main signaling pathways targeted by medical treatments of advanced sporadic gastro-entero-pancreatic(GEP)and bronchopulmonary(BP)neuroendocrine *** scientific literature regarding treatment of advanced GEP and BP-NETs has been extensively reviewed using MEDLINE and PubMed databases,selecting principal and more recent research articles,clinical trials,and updated *** analogues represent a valid approach to control symptoms in functioning tumors and to inhibit tumor progression in certain categories on the basis of the typical somatostatin receptor expression observed in *** pathogenesis of NETs has been the subject of increased interest in recent *** driver mutations pathway genes have been identified as important factors in the carcinogenesis process and,therefore,as potential targets for new anticancer *** mutations have been shown in epidermal growth factor receptor,stem cell factor receptor,platelet-derived growth factor receptor,vascular endothelial growth factor,basic-fibroblastic growth factor,transforming growth factor,insulin-like growth factor-1,and their *** M-Tor inhibition pathway modulation has led to the approval of drugs in this field such as *** drugs and several combination regimens with targeted and newer biological agents are being developed and tested in recently conducted and ongoing trials.

关键词： gastrointestinal and bronchopulmonary neuroendocrine tumors advanced disease medical treatment targeted agents

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