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gastrointestinal symptoms and associated factors in Chinese patients with functional dyspepsia

World Journal of Gastroenterology 2013年第32期19卷 5357-5364页

作者： Jiao Yu Shi Liu Xiu-Cai Fang Jun Zhang Jun Gao Ying-Lian Xiao Li-Ming Zhu Fen-Rong Chen Zhao-Shen Li Pin-Jin Hu Mei-Yun Ke Xiao-Hua Hou Division of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Division of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Sciences Division of Gastroenterology Second Affiliated Hospital of Medical CollegeXi’an Jiaotong University Division of Gastroenterology Changhai HospitalSecond Military Medical University Division of Gastroenterology First Affiliated Hospital of Sun Yat-sen University

AIM: To study the evolution of gastrointestinal symptoms and associated factors in Chinese patients with functional dyspepsia (FD).METHODS: From June 2008 to November 2009, a total of 1049 patients with FD (65.3% female, mean age 42.80 ± 11.64 years) who visited the departments of gastroenterology in Wuhan, Beijing, Shanghai, Guangzhou, and Xi’an, China were referred for this study. All of the patients fulfilled the Rome III criteria for FD. Baseline demographic data, dyspepsia symptoms, anxiety, depression, sleep disorder, and drug treatment were assessed using self-report questionnaires. Patients completed questionnaires at baseline and after 1, 3, 6 and 12 mo follow-up. Comparison of dyspepsia symptoms between baseline and after follow-up was explored using multivariate analysis of variance of repeated measuring. Multiple linear regression was done to examine factors associated with outcome, both longitudinally and horizontally.RESULTS: Nine hundred and forty-three patients (89.9% of the original population) completed all four follow-ups. The average duration of follow-up was 12.24 ± 0.59 mo. During 1-year follow-up, the mean dyspeptic symptom score (DSS) in FD patients showed a significant gradually reduced trend (P symptoms (P < 0.001). Multiple linear regression analysis showed that sex (P < 0.001), anxiety (P = 0.018), sleep disorder at 1-year follow-up (P = 0.019), weight loss (P < 0.001), consulting a physician (P < 0.001), and prokinetic use during 1-year follow-up (P = 0.035) were horizontally associated with DSS at 1-year follow-up. No relationship was found longitudinally between DSS at 1-year follow-up and patient characteristics at baseline.CONCLUSION: Female sex, anxiety, and sleep disorder, weight loss, consulting a physician and prokinetic use during 1-year follow-up were associated with outcome of FD.

关键词： Functional dyspepsia gastrointestinal symptoms Dyspeptic symptom score Helicobacter pylori infection Postprandial distress syndrome Epigastric pain syndrome Rome III criteria

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gastrointestinal symptoms as the first sign of chronic granulomatous disease in a neonate: A case report

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World Journal of Clinical Cases 2021年第32期9卷 9997-10005页

作者： Er-Yan Meng Zi-Ming Wang Bing Lei Li-Hong Shang Division of Neonatology The Third Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Chongqing Medical College Chongqing 400016China

BACKGROUND Chronic granulomatous disease(CGD)characterized by recurrent and severe bacterial and fungal infections is most common in *** SUMMARY We reported a 24-d-old male infant who developed gastrointestinal symptoms as the first sign of *** gastrointestinal symptoms representing the first sign of CGD are very rare,and prompt diagnosis and treatment with broad-spectrum antibiotics were of crucial importance.

关键词： Chronic granulomatous disease gastrointestinal symptoms Infant Neonate Fever Diarrhea

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gastrointestinal symptoms in patients with COVID-19: Is there a relationship with mortality and new variations of SARS-CoV-2?

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World Journal of Gastroenterology 2021年第37期27卷 6345-6347页

作者： Igor Braga Ribeiro Diogo Turiani Hourneaux de Moura Eduardo Guimarães Hourneaux de Moura Departamento de Gastroenterologia Serviço de Endoscopia Gastrointestinal do Hospital das Clínicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao Paulo 05403-010Brazil

Coronavirus disease 2019(COVID-19)is caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Although,respiratory symptoms are typical the digestive system is also a susceptible target with gastrointestinal symptoms present even in the absence of respiratory *** gastrointestinal symptoms of COVID-19 include diarrhea,abdominal pain,anorexia,and nausea among other *** questions that remain to be answered include:Do patients with gastrointestinal symptoms have a higher mortality?SARS-CoV-2 variants are already a global reality:Do these variants present with a greater prevalence of gastrointestinal symptoms?Do patients with these symptoms warrant more intensive care unit care?

关键词： COVID-19 SARS-CoV-2 gastrointestinal symptoms Intensive care unit Variant

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Clinical characteristics of patients with COVID-19 presenting with gastrointestinal symptoms as initial symptoms: Retrospective case series

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World Journal of Clinical Cases 2020年第14期8卷 2950-2958页

作者： Yun Yang Yuan-Chao Li Si-Cong Wang Qing-Qing Dai Xue-Song Jiang Shu Zuo Liu Jia Jun-Bo Zheng Hong-Liang WangDepartment of Critical Care Medicine the Second Affiliated Hospital of Harbin Medical University Harbin 150001Heilongjiang ProvinceChina Department of Critical Care Medicine the Cancer Hospital of Harbin Medical UniversityHarbin 150081Heilongjiang ProvinceChina

BACKGROUND A large number of pneumonia cases due to coronavirus disease 2019(COVID-19)have been first reported in ***,the virus is sweeping all around the world and has infected millions of *** and pulmonary symptoms have been noticed as major and early signs of infection,whereas gastrointestinal symptoms were also observed in a significant portion of *** clinical investigation of disease onset was underestimated,especially due to the neglection of cases presenting with gastrointestinal *** To characterize the clinical features of coronavirus-infected patients with gastrointestinal symptoms as initial *** This is a retrospective,single-center case series of the general consecutive hospitalized patients with confirmed COVID-19 at Wuhan Union Hospital from February 2,2020 to February 13,*** to their initial symptoms,these patients were classified into two *** in group one presented with pulmonary symptoms(PS)as initial symptoms,and group two presented with gastrointestinal symptoms(GS).Epidemiological,demographic,clinical,laboratory,and treatment data were collected for *** Among the 50 patients recruited,no patient has been admitted to intensive care units,and no patient died during the *** duration of hospitalization was longer in the GS group than in the PS group(12.13±2.44 vs 10.00±2.13,Pgastrointestinal symptoms as initial symptoms need more days of viral shedding and hospitalization than the patients presenting

关键词： COVID-19 Initial symptoms gastrointestinal symptoms Hospitalization Viral transmission

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Pathophysiological mechanisms underlying gastrointestinal symptoms in patients with COVID-19

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World Journal of Gastroenterology 2021年第19期27卷 2341-2352页

作者： Byungchang Jin Rajan Singh Se Eun Ha Hannah Zogg Paul J Park Seungil Ro Department of Physiology and Cell Biology University of Nevada School of MedicineRenoNV 89557United States Department of Medicine Renown HealthRenoNV 89557United States

gastrointestinal(GI)symptoms,such as diarrhea,abdominal pain,vomiting,and anorexia,are frequently observed in patients with coronavirus disease 2019(COVID-19).However,the pathophysiological mechanisms connecting these GI symptoms to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infections remain *** studies indicate that the entry of SARS-CoV-2 into intestinal cells leads to downregulation of angiotensin converting enzyme 2(ACE2)receptors resulting in impaired barrier *** intestinal ACE2 functions as a chaperone for the amino acid transporter B0AT1,the B0AT1/ACE2 complex within the intestinal epithelium acts as a regulator of gut microbiota composition and *** to the B0AT1/ACE2 complex lead to microbial dysbiosis through increased local and systemic immune *** studies have also suggested that altered serotonin metabolism may be the underlying cause of GI disorders involving *** findings of elevated plasma serotonin levels and high fecal calprotectin in COVID-19 patients with diarrhea indicate that the viral infection evokes a systemic inflammatory response that specifically involves the ***,the elevated proinflammatory cytokines correlate with elevated serotonin and fecal calprotectin levels further supporting the evidence of GI inflammation,a hallmark of functional GI ***,the finding that rectal swabs of COVID-19 patients remain positive for SARS-CoV-2 even after the nasopharynx clears the virus,suggests that viral replication and shedding from the GI tract may be more robust than that of the respiratory tract,further indicating fecal-oral transmission as another important route of viral *** review summarized the evidence for pathophysiological mechanisms(impaired barrier function,gut inflammation,altered serotonin metabolism and gut microbiota dysbiosis)underlying the GI symptoms in patients with COVID-19.

关键词： COVID-19 gastrointestinal symptoms Gut microbiota dysbiosis Impaired barrier function Serotonin Angiotensin converting enzyme 2 receptor

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Correlation between the neuroendocrine axis,microbial species,inflammatory response,and gastrointestinal symptoms in irritable bowel syndrome

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World Journal of Gastroenterology 2024年第35期30卷 3985-3995页

作者： Xin Zhang Wei-Wei Jin Hong-Gang Wang Department of Gastroenterology Tongde Hospital of Zhejiang ProvinceTaizhou 524333Zhejiang ProvinceChina Department of Nutrition Tongde Hospital of Zhejiang ProvinceTaizhou 524333Zhejiang ProvinceChina Department of Gastroenterology Taizhou Municipal HospitalTaizhou 524333Zhejiang ProvinceChina

BACKGROUND This study examines the complex relationships among the neuroendocrine axis,gut microbiome,inflammatory responses,and gastrointestinal symptoms in patients with irritable bowel syndrome(IBS).The findings provide new insights into the pathophysiology of IBS and suggest potential therapeutic targets for improving patient *** To investigate the interactions between the neuroendocrine axis,gut microbiome,inflammation,and gastrointestinal symptoms in patients with *** Patients diagnosed with IBS between January 2022 and January 2023 were selected for the *** individuals undergoing routine check-ups during the same period served as the control *** were collected on neuroendocrine hormone levels,gut microbiome profiles,inflammatory biomarkers,and gastrointestinal symptomatology to analyze their interrelations and their potential roles in IBS *** IBS patients exhibited significant dysregulation of the neuroendocrine axis,with altered levels of cortisol,serotonin,and neuropeptides compared to healthy *** gut microbiome of IBS patients showed reduced diversity and specific alterations in bacterial genera,including Bifidobacterium,Lactobacillus,and Faecalibacterium,which were associated with neuroendocrine ***,elevated levels of inflammatory markers,such as C-reactive protein,interleukin-6,and tumor necrosis factor-α,were observed and correlated with the severity of gastrointestinal symptoms like abdominal pain,bloating,and altered bowel *** The findings suggest that targeting the neuroendocrine axis,gut microbiome,and inflammatory pathways may offer novel therapeutic strategies to alleviate symptoms and improve the quality of life in IBS patients.

关键词： gastrointestinal symptoms Inflammatory response Intestinal microbiota Irritable bowel syndrome Neuroendocrine axis Relationship study

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Improving early diagnosis of multiple endocrine neoplasia type 1 by assessing the gastrointestinal symptoms,hypercalcemia,and elevated serum gastrin

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World Journal of Gastroenterology 2024年第43期30卷 4677-4681页

作者： Tsvetelina Velikova Velik Lazarov Medical Faculty Sofia University St.Kliment OhridskiSofia 1407Bulgaria Obstetrics and Gynaecology Second Specialised Hospital for Obstetrics and Gynaecology“Sheynovo”Sofia 1504Bulgaria

Despite advancements in the field,early diagnosis of multiple endocrine neoplasia type 1(MEN1)remains *** letter to the editor highlighted the importance of carefully assessing gastrointestinal symptoms,hypercalcemia,and elevated serum gastrin levels,as suggested by Yuan et al in their *** focused on a patient with recurrent abdominal pain and diarrhea whose diagnostic path led to establishing a MEN1 diagnosis within a *** emphasized the need for clinicians to consider MEN1 in patients with similar presentations,particularly when gastrointestinal symptoms persist or recur after discontinuation of proton pump inhibitors,especially knowing that early recognition and intervention are crucial for improving patient outcomes.

关键词： Multiple endocrine neoplasia type 1 gastrointestinal symptoms Hypercalcemia Early detection Early diagnosis

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Study on the occurrence and influencing factors of gastrointestinal symptoms in hemodialysis patients with uremia

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World Journal of gastrointestinal Surgery 2024年第7期16卷 2157-2166页

作者： Dan Yuan Xiao-Qi Wang Feng Shao Jing-Jing Zhou Zhong-Xin Li Department of Nephrology Beijing Luhe Hospital Affiliated to Capital Medical UniversityBeijing 101100China

BACKGROUND gastrointestinal symptoms are common in patients with uremia undergoing hemodialysis,and these symptoms seriously affect patients'*** To assess the occurrence and factors influencing gastrointestinal symptoms in patients with uremia undergoing *** We retrospectively selected 98 patients with uremia who underwent regular hemo-dialysis treatment in the blood purification center of our hospital from December 2022 to December *** gastrointestinal symptoms and scores of each dimension were evaluated using the gastrointestinal Symptom Grading Scale(GSRS).Patients were divided into gastrointestinal symptoms and no gastrointestinal symptom groups according to whether they had gastrointestinal *** factors that may affect gastrointestinal symptoms were identified by single-factor *** logistic regression analysis was performed to identify independent risk factors for gastrointestinal *** gastrointestinal symptoms included indigestion,constipation,reflux,diarrhea,abdominal pain,and eating disorders,and the total average GSRS score was 1.35±*** study showed that age,number of tablets,dialysis time,glucocorticoid,parathyroid hormone(PTH),combined diabetes mellitus and C-reactive protein(CRP)were independent risk factors for gastrointestinal symptoms in patients with uremia undergoing hemodialysis,whereas body mass index(BMI),hemoglobin(Hb),and urea clearance index were independent protective factors(Pgastrointestinal symptoms are mostly mild in patients with uremia undergoing hemodialysis,most commonly including dyspepsia,eating disorders,and gastroesophageal *** independent influencing factors mainly include the BMI,age,number of pills taken,dialysis time,urea clearance index,Hb,use of glucocorticoids,and thyroid hormone ***,CRP,and diabetes are clinically related factors influencing the occurrence of gastrointestinal symptoms,and targeted prevention can be perform

关键词： Uremic hemodialysis gastrointestinal symptoms Influencing factors Blood pressure dialysis Chronic renal failure

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Observation on the Nursing Effect of Ginger Moxibustion on gastrointestinal symptoms in Patients with Heart Failure Due to Yang Qi Deficiency

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Journal of Clinical and Nursing Research 2024年第6期8卷 135-141页

作者： Yijing Wang Xuzhou Hospital of Traditional Chinese Medicine Xuzhou 221000Jiangsu ProvinceChina

Objective:To evaluate the nursing measures and effects of ginger moxibustion in the treatment of heart failure(yang qi deficiency type)with gastrointestinal ***:86 patients with heart failure(yang qi deficiency type)accompanied by gastrointestinal symptoms who were admitted to the hospital between January 2023 and January 2024 were selected and divided into 43 cases in each group by random number table grouping;Group I implemented integrated care,while Group II adopted conventional *** indicators of care were compared between the two ***:After the nursing care,the digestive symptom scores of Group I were lower than those of Group I,and the psychological scores were lower than those of Group II(Pgastrointestinal symptoms and enhance the psychological health of patients with heart failure(yang qi deficiency type)with gastrointestinal symptoms.

关键词： Ginger moxibustion Yang qi deficiency Heart failure gastrointestinal symptoms

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Weight Loss and gastrointestinal symptoms in Advanced Cancer Patients Treated with Platinum-based Chemotherapy

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Journal of Nutritional Oncology 2020年第2期5卷 97-104页

作者： Hui Gao Dong Bo Liu Jin Tong Jing Han Bo Liu Si Xian Zhu Liu Huang Ying Yao Shi Ying Yu Qiang Fu Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Clinical Nutrition Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Peripherally Inserted Central Venous Catheters(PICC) Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective This study assessed the weight loss changes and gastrointestinal symptoms in patients with advanced tumors receiving platinum-containing *** We retrospectively reviewed 297 patients with advanced cancers[124 gastrointestinal(GI)cancer patients,119 lung cancer patients and 54 head and neck cancer(HNC)patients]receiving first-line chemotherapy at Tongji *** patients’changes in body weight,body mass index(BMI),and biochemical parameters(serum haemoglobin and albumin levels)were compared before and after two chemotherapy *** More than half[54.88%(163/297)]of the patients had experienced unintentional weight loss in the 6 months before chemotherapy,and weight loss≥5%and≥10%of the body mass was noted in 35.69%and 20.20%of the patients,*** two cycles of platinum-based chemotherapy,the proportions of patients with a>5%reduction in body weight among patients with GI,lung,and head and neck cancers were 47.5%(59/124),44.53%(53/119),and 46.2%(25/54),*** patients with GI and lung cancers were more vulnerable to extreme weight loss(≥10%)than those with HNC(P=0.025).The serum hemoglobin levels were also remarkably decreased relative to those before chemotherapy(all Psymptoms reported by all patients included anorexia(61.28%),vomiting(52.53%),and nausea(51.18%).A higher proportion of patients with≥10%weight loss experienced anorexia and vomiting(OR=12.21 and 3.61,P=0.008 and 0.047,respectively).Conclusions For advanced cancer patients receiving platinum-based chemotherapy,the GI symptoms are the major factor related to their nutritional *** nutritional screening,evaluation and treatment should be applied during the treatment of cancer in order to reduce GI symptoms and improve the patient’s nutritional status.

关键词： Weight loss Platinum-based chemotherapy gastrointestinal symptoms Hemoglobin

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