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Therapeutic potential of gastrodia elata blume for the treatment of Alzheimer's disease

Neural Regeneration Research 2013年第12期8卷 1061-1070页

作者： Guang-Biao Huang Tong Zhao Sushma Shrestha Muna Hong-Mei Jin Jong-Il Park Kyu-Sik Jo Bo-Hee Lee Soo-Wan Chae Sun-Young Kim Soo-Hyun Park Eun-Ock Park Eun-Kyung Choi Young-Chul Chung Department of Psychiatry Chonbuk National University Medical SchoolJeonju 561-756 Republic of Korea Muju Chunma Native Local Industrial Center Muju 568-844 Republic of Korea Clinical Trial Center for Functional Foods Chonbuk National University HospitalJeonju 561-756 Republic of Korea Department of Pharmacology Chonbuk National University Medical SchoolJeonju 561-756 Republic of Korea

Several studies have demonstrated that the Chinese herb gastrodia elata blume can protect against amyloid beta-peptide （Ap）-induced cell death. To investigate the possible therapeutic effects of gastrodia elata blume on Alzheimer＇s disease, we established a rat model of AIzheimer＇s disease by injecting A325-35 into bilateral hippocampi. These rats were intragastrically administered 500 or 1 000 mg/kg gastrodia elata blume per day for 52 consecutive days. Morris water maze tests showed that gastrodia elata blume treatment significantly improved the spatial memory of Alzheimer＇s disease rats. Congo red staining revealed that gastrodia elata blume significantly reduced the number of amyloid deposits in the hippocampus of these rats. Western blot analysis showed that choline acetyltransferase expression in the medial septum and hippocampus was significantly increased by the treatment of gastrodia elata blume, while EIIman method showed significant decrease in the activity of acetylcholinesterase in all three regions （prefrontal cortex, medial septum and hippocampus）. These findings suggest that long-term administration of gastrodia elata blume has therapeutic potential for Alzheimer＇s disease.

关键词： neural regeneration neuroprotective effect Traditional Chinese medicine gastrodia elata blume Alzheimer's disease Morris water maze test choline acetyltransferase acetylcholinesterase grants-supported paper neuroregeneration

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天麻(gastrodia elata blume)的药理与应用

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云南医药 1980年第4期 48-53页

作者：邓士贤莫云强昆明医学院药理学教研组昆明制药厂中心试验室

天麻又名赤箭,属蓝科(Orchida Ceae)植物,产于云南、四川、贵州、陕西、安徽及湖北等地,药用干燥块茎,系我国贵重的中药。两千多年前《神农本草经》早已记载了天麻的功效,天麻“久服益气力长”。明朝李时珍《本草纲目》记载:“天麻辛、... 详细信息

天麻又名赤箭,属蓝科(Orchida Ceae)植物,产于云南、四川、贵州、陕西、安徽及湖北等地,药用干燥块茎,系我国贵重的中药。两千多年前《神农本草经》早已记载了天麻的功效,天麻“久服益气力长”。明朝李时珍《本草纲目》记载:“天麻辛、温、无毒。久服益气,轻身长年”,治疗“语多恍惚,善惊失忘”。亦有文献记载天麻能“熄风定惊”。化学成分早期研究:1936年 Mar 及 Read 二氏测定天麻含维生素 A,含量为

关键词：天麻人工合成化学成分平肝熄风药 gastrodia elata blume 药理研究

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中国药用植物——天麻(gastrodia elata blume)

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华中师院学报(自然科学版) 1980年第3期 61-67页

作者：苏宏汉华中师院生物系

天麻是我国著名药材之一,向视为珍品,本文阐述其历史,特性及其药用部分的块茎(天麻)之所以形成,与蜜环菌的关系。末后选例示天麻的治病效果,以广应用.

关键词：蜜环菌榛蘑中国药用植物块茎地下茎 gastrodia elata blume 天麻平肝熄风药菌索菌束

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Cardiovascular protective properties of gastrodin

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Asian Pacific Journal of Tropical Biomedicine 2022年第4期12卷 141-147页

作者： Shu-Ting Yang Shu-Bai Liu School of Life Sciences Yunnan UniversityKunming 650091YunnanChina State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming650201YunnanChina

Cardiovascular diseases cause significant morbidity and mortality worldwide,incurring a major public health *** elata blume is a traditional Chinese herbal medicine that has been widely used to treat central nervous system and cardiovascular ***,as the major active component in gastrodia elata blume,can confer protection against cardiovascular *** this review,we summarize the anti-inflammatory actions,anti-cardiac hypertrophy,anti-hypertension,anti-atherosclerosis,and angiogenic effects of gastrodin,as well as its protective effects on vascular cells and against myocardial ischemia-reperfusion *** medical potential of gastrodin in diabetes-related cardiovascular diseases is also discussed.

关键词： Gastrodin Cardiovascular diseases Myocardial ischemia-reperfusion injury gastrodia elata blume Anti-atherosclerosis Cardio-protection

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Gastrodin Derivatives from gastrodia elata

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Natural Products and Bioprospecting 2019年第6期9卷 393-404页

作者： Cheng-Bo Xu Qing-Lan Guo Ya-Nan Wang Sheng Lin Cheng-Gen Zhu Jian-Gong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050People’s Republic of China

Nine new gastrodin derivatives,including seven p-hydroxybenzyl-modified gastrodin ethers(1-7),6′-O-acetylgastrodin(8),and 4-[α-d-glucopyranosyl-(1→6)-β-d-glucopyranosyloxy]benzyl alcohol(9),together with seven known derivatives,were isolated from an aqueous extract of gastrodia elata(“tian ma”)*** structures were determined by spectroscopic and chemical methods as well as single crystal X-ray *** 1-4,7,10,and 11 were also isolated from a reaction mixture by refluxing gastrodin and p-hydroxybenzyl alcohol in *** both gastrodin and p-hydroxybenzyl alcohol exist in the plant,the reaction results provide evidence for the production and increase/decrease of potential effective/toxic components when“tian ma”is decocted solely or together with ingredients in Chinese traditional medicine formulations,though the isolates were inactive in the preliminarily cell-based assays at concentrations of 10μ***,using ultra-performance liquid chromatography high-resolution electrospray ionization mass spectrometry(UPLC-HRESIMS),4,7,10,and 11,as well as component variations,were detectable in the freshly prepared extracts of different types of samples,including the freeze-dried fresh *** rhizomes.

关键词： Orchidaceae gastrodia elata blume p-Hydroxybenzyl gastrodin ethers Reaction of gastrodin with p-hydroxybenzyl alcohol Component variation during decocting

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陇南的天麻生产现状与发展对策

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林业科技通讯 2021年第11期 61-65页

作者：乔旭田茂琳王国祥尹玉保武建华王云霞张慧张梅陇南市农业科学研究所甘肃陇南746000 陇南市科学技术协会甘肃陇南746000 甘肃省农业科学院中药材研究所康县中药材技术指导站康县华凤天麻种植农民专业合作社

陇南的天麻(gastrodia elata blume)天麻素含量高,品质好。由于国家退耕还林政策,天麻产业的发展受到限制。天麻生产的关键环节萌发菌、蜜环菌和麻种生产技术和育种技术滞后,药农种植天麻的技术同样落后于周边产区。本文在广泛调查的基... 详细信息

陇南的天麻(gastrodia elata blume)天麻素含量高,品质好。由于国家退耕还林政策,天麻产业的发展受到限制。天麻生产的关键环节萌发菌、蜜环菌和麻种生产技术和育种技术滞后,药农种植天麻的技术同样落后于周边产区。本文在广泛调查的基础上对陇南天麻的生产现状进行了概述,并针对生产中存在的问题提出了发展建议。

关键词：天麻 gastrodia elata blume 发展现状陇南

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