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Updates on gastric electrical stimulation to treat obesity: Systematic review and future perspectives

World Journal of Gastrointestinal Endoscopy 2014年第9期6卷 419-431页

作者： Ryan Cha Jacques Marescaux Michele Diana IHU-Stras-bourg Image-Guided Minimally Invasive Surgical Institute University of Strasbourg IRCAD Digestive and Endocrine Surgery University of Strasbourg

AIM: To evaluate the current state-of-the-art of gastric electrical stimulation to treat obesity. METHODS: Systematic reviews of all studies have been conducted to evaluate the effect of different types of gastric electrical stimulation(GES) on ***: Thirty-one studies consisting of a total of 33 different trials were included in the systematic review for data analysis. Weight loss was achieved in most studies, especially during the first 12 mo, but only very few studies had a follow-up period longer than 1 year. Among those that had a longer follow-up period, many were from the Transcend(Implantable gastric stimulation) device group and maintained significant weight loss. Other significant results included changes in appetite/satiety, gastric emptying rate, blood pressure and neurohormone levels or biochemical markers such as ghrelin or HbA1 c respectively. CONCLUSION: GES holds great promises to be an effective obesity treatment. However, stronger evidence is required through more studies with a standardized way of carrying out trials and reporting outcomes, to determine the long-term effect of GES on obesity.

关键词： gastric electrical stimulation TANTALUS system Transcend implantable gastric stimulator Retrograde gastric electrical stimulation gastric vagal nerve stimulation gastric pacing EMPOWER trial Dual-lead implantable gastric electrical stimulation trial Laparoscopic obesity stimulation survey Screened health assessment and pacer evaluation

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