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Immune function, gastrointestinal hormone levels, and their clinical significance in patients with gastric ulcers complicated with depression

引用

World Journal of Psychiatry 2023年第9期13卷 665-674页

作者： Yun-Han Yang De-Jun Cui Zai-Li Yang Wen-Qiang Yuan Bo Huang Department of Gastroenterology Guizhou Inflammatory Bowel Disease Research CenterNational Institution of Drug Clinical TrialGuizhou Provincial People’s HospitalMedical College of Guizhou UniversityGuiyang 550002Guizhou ProvinceChina

BACKGROUND gastric ulcer(GU)is a common digestive tract disease,and medical records of GU combined with depression are increasingly ***,the risk factors and pathogenesis of GU complicated with depression remain *** immune function and gastrointestinal hormone levels may also be significant risk ***,this study explored the immune function and gastrointestinal hormone levels in patients with GU combined with *** To explore the immune function,gastrointestinal hormone level,and clinical significance of patients with GU combined with *** A retrospective analysis was conducted on 300 patients with GU combined with depression admitted to Guizhou Provincial People’s Hospital from January 2021 to June 2022 as the study *** to the Hamilton depression Scale(HAMD)score,patients were divided into mild-to-moderate(n=210)and heavy(n=90)*** data,immune function indices[immunoglobulin A(IgA),IgM,IgG,serum CD4+and CD8+percentage,and CD4+/CD8+ratio],and gastrointestinal hormone indices[serum gastrin(GAS),cholecystokinin(CCK),and motilin(MTL)levels]were *** basic data of the two groups were compared,and the immune function and gastrointestinal hormone indices were *** logistic regression was used to analyze the factors influencing the severity of GU complicated with *** receiver operating characteristic(ROC)curve and area under the ROC curve(AUC)were used to analyze the value of the immune function index,gastrointestinal hormone index,and combined index in predicting the severity of GU complicated with *** There were no marked differences in sex,age,body mass index,abdominal distension,abdominal pain,belching,nausea,vomiting,or sleep disorders between the heavy and mild-to-moderate groups(P>0.05).There was a marked difference in the family history of depression between the heavy and mild-to-moderate groups(P<0.05).There were significant differences

关键词： gastric ulcer combined with depression Immune function Gastrointestinal hormones

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