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Altered Expression Profile of Micro RNAs in gastric stromal tumor

Journal of Huazhong University of Science and Technology(Medical Sciences) 2015年第6期35卷 842-850页

作者：肖军汪其贤朱尤庆 Department of Gastroenterology and Hubei Provincial Center of Clinical Study for Digestive Diseases Zhongnan Hospital Wuhan University

Summary： MicroRNAs （miRNAs） play important roles in carcinogenesis, but the global miRNA ex- pression profile in gastric stromal tumor tissues remains unclear. This study was to examine the miRNA expression profile in gastric stromal tumor tissues and explore the function of dysregulated miRNAs by performing gene ontology （GO） and pathway enrichment analysis. Total RNA was extracted and puri- fied from 3 pairs of frozen gastric stromal tumor tissues and the adjacent non-tumor tissues by using mirVanaTM miRNA isolation kit. The miRNA expression was analyzed with Affymetrix microarrays （version 4.0） containing 2578 human mature microRNA probes. The dysregulated microRNAs were validated by quantitative RT-PCR in 30 pairs of gastric stromal tumor tissues. The target gene of the dysregulated microRNAs was predicted by miRanda, TargetScan and PicTar. GO and pathway enrich- ment analysis was conducted to examine the potential function of miR-3178 and miR-193a-5p. The re- suits showed that there were 12 differently expressed microRNAs in gastric stromal tumor tissues, among which 10 miRNAs were down-regulated, and 2 were up-regulated （P〈0.05）. The validation re- sults by RT-PCR were in accordance with those by microRNA microarry. GO analysis found that the target genes of miR-3178 were involved in 5 GO terms and those of miR-193a-5p in 7 GO terms in level 2. Pathway enrichment analysis suggested that miR-3178 and miR-193a-5p were related to 57 and 122 signaling pathways, respectively. It was concluded that gastric stromal tumor displays a unique miRNA signature. This specific expression may become a new diagnostic and prognostic biomarker for gastric stromal ~xnor. miR-3178 and miR-193a-5p function as suppressive microRNAs, and they may also become diagnosis and treatment targets for gastric stromal tumor.

关键词： microRNA gastric stromal tumor signal pathway gene

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Relationship between Ki-67 and CD44 expression and microvascular formation in gastric stromal tumor tissues

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World Journal of Clinical Cases 2022年第2期10卷 469-476页

作者： Bing Ma Xiao-Tian Huang Gui-Jun Zou Wen-Yu Hou Xiao-Hui Du Department of General Surgery The PLA General HospitalBeijing 100853China

BACKGROUND A gastric stromal tumor(GST)is a mesenchymal tumor that occurs in the gastrointestinal tract;its biological characteristics are highly ***,the severity of a GST is often evaluated by factors such as risk classification,tumor size,and mitotic ***,these indicators are not very *** patients classified as low risk are also at risk of metastasis and ***,more accurate and objective clinical biological behavior evaluations are urgently *** To determine the relationship between Ki-67 and CD44 expression in GSTs and microvessel formation and *** Eighty-six GST tissue specimens from our hospital were selected for this *** immunohistochemical staining technique was used to detect Ki-67,CD44,and microvessel density(MVD)in the collected samples to analyze the different risk grades and mitotic *** addition,this approach was used to determine the differences in the expression of Ki-67 and CD44 in GST tissues with varying lesion *** In GSTs with positive expression of the Ki-67 protein,the proportions of patients with medium-to-high risk and more than five mitotic counts were 24.07%and 38.89%,*** GSTs with positive expression of the CD44 protein,the proportions of patients with medium-to-high risk and more than five mitotic counts were 23.73%and 38.98%,*** GSTs with negative expression of the Ki-67 protein,these values were relatively high(3.70%and 11.11%,respectively).The MVD in GSTs with positive and negative expression of the CD44 protein was 15.92±2.94 and 13.86±2.98/Hp,respectively;the difference between the two groups was significant(Ptumor risk and mitotic ***44 expression is correlated with microvessel formation in tumor tissues.

关键词： gastric stromal tumor Ki-67 CD44 Expression Microvascular formation Formation of microvessels

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Splenosis masquerading as gastric stromal tumor: A case report

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World Journal of Clinical Cases 2021年第20期9卷 5724-5729页

作者： Hui-Da Zheng Jian-Hua Xu Ya-Feng Sun Department of Gastrointestinal Surgery The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

BACKGROUND Splenosis is a rare benign disease that often disguises itself as a malignant *** are few articles providing a comprehensive description of splenosis,especially cases located in the stomach being treated by laparoscopic *** SUMMARY A 44-year-old man presented with recurrent upper abdominal pain for more than half a *** patient had splenic rupture caused by trauma more than 10 years ago and underwent *** abdominal contrast-enhanced computed tomography scan revealed an irregular soft tissue *** revealed an approximately 3.0 cm×3.0 cm mucosal eminence at the posterior wall of the upper segment of the gastric *** was not performed since the lesion was found under the mucosa and the gastric mucosa appeared *** to these findings,a diagnosis of gastric stromal tumor was made,although a definitive differential diagnosis was not known before *** laparoscopic resection of the gastric stromal tumor was performed,an astonishing finding was made when postoperative pathology showed that the lesion comprised typical spleen *** This case highlights the strong similarities between splenosis and malignant tumors.A detailed medical history combined with various effective auxiliary examinations can help improve differential diagnosis.

关键词： Splenosis gastric stromal tumor Laparoscopy Case report

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Multi-slice spiral computed tomography in differential diagnosis of gastric stromal tumors and benign gastric polyps,and gastric stromal tumor risk stratification assessment

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World Journal of Gastrointestinal Oncology 2022年第10期14卷 2004-2013页

作者： Xiao-Long Li Peng-Fei Han Wei Wang Li-Wei Shao Ying-Wei Wang Diagnostic Radiology Department The First Medical Center of PLA General HospitalBeijing 100853China Pathology Department The Seventh Medical Center of PLA General HospitalBeijing 100700China

BACKGROUND The biological characteristics of gastric stromal tumors are complex,and their incidence has increased in recent *** stromal tumors(GST)have potential malignant tendencies,and the probability of transformation into malignant tumors is as high as 20%-30%.AIM To investigate the value of multi-slice spiral computed tomography(MSCT)in the differential diagnosis of GST and benign gastric polyps,and GST risk stratification *** We included 64 patients with GST(GST group)and 60 with benign gastric polyps(control group),confirmed by pathological examination after surgery in PLA General Hospital,from January 2016 to June *** differences in the MSCT imaging characteristic parameters and enhanced CT values between the two groups before surgery were *** to the National Institutes of Health’s standard,GST is divided into low-and high-risk groups for MSCT imaging characteristic parameters and enhanced CT *** The incidences of extraluminal growth,blurred boundaries,and ulceration in the GST group were significantly higher than those in the control group(Pgastric polyp sensitivity,specificity,misdiagnosis rate,missed diagnosis rate,and areas under the curve(AUCs)were 73.44%,83.33%,26.56%,16.67%,0.784,*** receiver operating characteristic curves were plotted with the arterial CT value and enhanced peak CT value,with a statistical *** results showed that the sensitivity,specificity,misdiagnosis rate,missed diagnosis rate,and AUC value of arterial CT in the differential diagnosis of GST and gastric polyps were 80.18%,62.20%,19.82%,37.80%,and 0.710,*** sensitivity,specificity,misdiagnosis rate,missed diagnosis rate,and AUC value of the enhanced peak CT value in the differential diagnosis of GST and gastri

关键词： Multi-slice spiral computed tomography Differential diagnosis gastric stromal tumor Benign gastric polyps Risk stratification

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Screening for Differentially Expressed Genes of gastric stromal tumor Originating from Muscularis Propria

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Chinese Medical Journal 2017年第6期130卷 737-740页

作者： Ju Huang Bo Zhang Liu-Ye Huang Department of Clinical Medicine Queen Mary School of Nanchang University Nanchang Jiangxi 330031 China Department of Gastroenterology Affiliated Yantai Yuhuangding Hospital of Qingdao University Yantai Shandong 264000 China

INTRODUCTION gastric stromal tumor （GST） is a set of gastrointestinal mesenchymal tumors those originate from interstitial cells of Cajal. Its early diagnosis and treatment are critical to prognosis. The occurrence of GST remains obscure; this study used Affymetrix expression spectrum chip to detect the gene expression spectrum of GST and explore new molecular target that is used in the treatment and prognosis of GST.

关键词： Gene Expression gastric stromal tumor Microarray Analysis Muscularis Propria

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Spontaneous rupture of the giant gastric stromal tumor(> 35 cm) as a rare cause of acute abdomen: a case report

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The Chinese-German Journal of Clinical Oncology 2014年第4期13卷 194-196页

作者： Libo Feng Dong Xia Qing Liu Yi Liu Liang Xu Department of Gastrointestinal Surgery The Affiliated Hospital of Luzhou Medical College

A case of spontaneous rupture of giant gastrointestinal stromal tumor(GIST) of stomach causing acute abdomen is described below. A male patient with abdominal mass presented with symptoms and signs of acute abdomen after admitting for 1 day. After preoperative management and evaluation, an exploratory laparotomy was performed, where rupture of a huge tumor in the stomach was found. A subtotal gastrectomy including the mass was performed and the final immunohistochemical examination verified that the neoplasm was a high risk GIST. The postoperative period was uneventful and the patient received treatment with imatinib mesylate, and regular follow-up without recurrence.

关键词： gastric stromal tumor rupture acute abdomen surgery

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Coexistence of esophageal blue nevus, hair follicles and basaloid sqamous carcinoma:A case report

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World Journal of Gastroenterology 2008年第26期14卷 4253-4256页

作者： Dong-Guan Wang Xin-Gong Li Hong Gao Xi-Yin Sun xiao-Qiu Zhou Department of Pathology Dongying People's Hospital Dongying 257091 Shandong Province China

We present the case of a 57-year-old man who underwent esophagectomy for esophageal carcinoma found at barium meal and gastroscopic examination. He was diagnosed as esophageal basaloid squamous carcinoma （BSC） and gastric stromal tumor, which were associated with focal proliferation of melanocytes/ pigmentophages and hair follicles in esophageal mucosa. Melanocytic hyperplasia （melanocytosis） has previously been recognized as an occasional reactive lesion, which can accompany esophageal inflammation and invasive squamous carcinoma. The present case is unusual because of its hyperplasia of not only melanocytes but also hair follicles. To our knowledge, this is the first report of esophageal blue nevus and hair follicle coexisting with BSC.

关键词： Esophagus Basaloid squamous carcinoma Blue nevus Hair follicle gastric stromal tumor

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Effect of gastroscopy combined with laparoscopy on gastric stromal tumors

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Journal of Hainan Medical University 2020年第18期26卷 57-60页

作者： Chun-Tao Ma Hai-Ling Zhang Yong-Dong Wang Shijiazhuang Cardiovascular and Cerebrovascular Disease Hospital 050000 Department of Gastroenterology Shijiazhuang First Hospital050000 Hebei Ningjin County Hospital 055500

Objective:To analyze the clinical effect of gastroscopy combined with laparoscopy in the treatment of gastric stromal ***:From January 2015 to December 2017,53 patients with gastric interstitial tumors were screened from the patients who were examined or admitted to our *** patients who were not suitable for surgical treatment with gastroscopy and laparoscopy will be *** a control group,a total of 21 patients were treated with open surgery;the remaining 32 patients were treated as a study group with gastroscopy combined with *** treatment,analyze intraoperative or postoperative indicators,pathological results,risk of tumor recurrence,and incidence of ***:The operation time in the study group was significantly longer than that in the control *** blood loss,abdominal drainage volume,exhaust time,analgesic use time,and hospital stay in the study group were significantly shorter than those in the control group,Ptumor results in the group,P>0.05,which was not statistically significant;the difference in recurrence risk between the study group and the control group was not significant,P>0.05;the incidence of complications was significantly lower in the study *** the control group,the difference was significant,Pgastric stromal tumors has a significant effect,is safe and reliable,and is worthy of clinical promotion.

关键词： Gastroscopy Laparoscopy gastric stromal tumor

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Clinical Control Study of Endoscopic Full-thickness Resection and Laparoscopic Surgery in the Treatment of gastric tumors Arising from the Muscularis Propria

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Chinese Medical Journal 2015年第11期128卷 1455-1459页

作者： Cheng-Rong Wu Liu-Ye Huang Juan Guo Bo Zhang Jun Cgi Cheng-Ming Sun Li-Xin Jiang Zhi-Hua Wang Ai-Hong Ju Department of Gastroenterology Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University Yantai Shandong 264000 China Department of Clinical Laboratory Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University Yantai Shandong 264000 China Department of Abdominal Surgery Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University Yantai Shandong 264000 China

Background： gastric stromal tumors arising from the muscularis propria are located in deeper layers. Endoscopic resection may be contraindicated due to the possibility of perforation. These tumors are therefore usually removed by surgical or laparoscopic procedures. This study evaluated the curative effects, safety and feasibility of endoscopic full-thickness resection （EFR） of gastric stromal tumors originating from the muscularis propria. Methods： This study enrolled 92 patients with gastric stromal tumors 〉2.5 cm originating from the muscularis propria. Fifty patients underwent EFR, and 42 underwent laparoscopic intragastric surgery. Operation time, complete resection rate, length of hospital stay, incidence of complications, and recurrence rates were compared in these two groups. Results： EFR resulted in complete resection of all 50 gastric stromal tumors, with a mean procedure time of 85± 20 min, a mean hospitalization time of 7.0± 1.5 days and no complications. Laparoscopic intragastric surgery also resulted in a 100% complete resection rate, with a mean operation time of 88 ± 12 min and a mean hospitalization period of 7.5 ± 1.6 days. The two groups did not differ significantly in operation time, complete resection rates, hospital stay or incidence of complications （P 〉 0.05）. No patient in either group experienced tumor recurrence. Conclusions： EFR technique is effective and safe for the resection of gastric stromal tumors arising from the muscularis propria.

关键词： Endoscopy Full-thickness Excision gastric stromal tumor Muscularis Propria Treatment

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