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Effect of two-channel gastric electrical stimulation with trains of pulses on gastric motility

World Journal of Gastroenterology 2009年第19期15卷 2406-2411页

作者： Bin Yang Xiao-Hua Hou Geng-Qing Song Jin-Song Liu Jiande DZ Chen Department of Gastroenterology Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430022 Hubei Province China Department of Gastroenterology University of Texas Medical Branch Galveston TX 77555-0655United States

AIM： To investigate the effect of two-channel gastric electrical stimulation （GES） with trains of pulses on gastric emptying and slow ***： Seven dogs implanted with four pairs of electrodes and equipped with a duodenal cannula were involved in this study. Two experiments were *** first experiment included a series of sessions in the fasting state with trains of short or long pulses, each lasted 10 min. A 5-min recording without pacing was made between two sessions. The second experiment was performed in three sessions （control, single-channel GES, and two-channel GES）. The stimulus was applied via the 1st pair of electrodes for single-channel GES （GES via one pair of electrodes located at 14 cm above the pylorus）, and simultaneously via the 1st and 3rd channels for two-channel GES （GES via two pairs of electrodes located at 6 and 14 cm above the pylorus）, gastric liquid emptying was collected every 15 min via the cannula for 90 ***： GES with trains of pulses at a pulse width of 4 ms or higher was able to entrain gastric slow waves. Two-channel GES was about 50% more efficient than single-channel GES in entraining gastric slow waves. Two-channel but not single-channel GES with trains of pulses was capable of accelerating gastric emptying in healthy dogs. Compared with the control session, two-channel GES significantly increased gastric emptying of liquids at 15 rain （79.0% ± 6.4% vs 61.3% ± 6.1%, P 〈 0.01）, 30 min （83.2% ± 6.3 % vs 68.2% ± 6.9%, P 〈 0.01）, 60 min （86.9% ± 5.5 % vs 74.1% ± 5.9%, P 〈 0.01）, and 90 rain （91.0% ± 3.4% vs 76.5% ± 5.9%, P 〈 0.01）.CONCLUSION： Two-channel GES with trains of pulses accelerates gastric emptying in healthy dogs and may have a therapeutic potential for the treatment of gastric motility disorders.

关键词： gastric electrical stimulation gastric slowwaves gastric emptying Gastrointestinal motility gastric pacing

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gastric stimulation for weight loss

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World Journal of Gastroenterology 2012年第19期18卷 2309-2319页

作者： Meir Mizrahi Ami Ben Ya'acov Yaron Ilan Gastroenterology and Liver Units Hebrew University-Hadassah Medical CenterEin-KaremJerusalemPOB1200Israel

The prevalence of obesity is growing to epidemic proportions,and there is clearly a need for minimally invasive therapies with few adverse effects that allow for sustained weight *** and lifestyle therapy are safe treatments for obesity in the short term,but the durability of the weight loss is *** promising obesity drugs are in development,the currently available drugs lack efficacy or have unacceptable side *** leads to long-term weight loss,but it is associated with morbidity and *** electrical stimulation(GES) has received increasing attention as a potential tool for treating obesity and gastrointestinal dysmotility *** is a promising,minimally invasive,safe,and effective method for treating *** gastric pacing is aimed at alteration of the motility of the gastrointestinal tract in a way that will alter absorption due to alteration of transit *** addition,data from animal models and preliminary data from human trials suggest a role for the gut-brain axis in the mechanism of *** may involve alteration of secretion of hormones associated with hunger or *** selection for gastric stimulation therapy seems to be an important determinant of the treatment's ***,we review the current status,potential mechanisms of action,and possible future applications of gastric stimulation for obesity.

关键词： Obesity gastric stimulation gastric motil-ity External pacing gastric pacing Intestinal pacing

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Updates on gastric electrical stimulation to treat obesity: Systematic review and future perspectives

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World Journal of Gastrointestinal Endoscopy 2014年第9期6卷 419-431页

作者： Ryan Cha Jacques Marescaux Michele Diana IHU-Stras-bourg Image-Guided Minimally Invasive Surgical Institute University of Strasbourg IRCAD Digestive and Endocrine Surgery University of Strasbourg

AIM: To evaluate the current state-of-the-art of gastric electrical stimulation to treat obesity. METHODS: Systematic reviews of all studies have been conducted to evaluate the effect of different types of gastric electrical stimulation(GES) on ***: Thirty-one studies consisting of a total of 33 different trials were included in the systematic review for data analysis. Weight loss was achieved in most studies, especially during the first 12 mo, but only very few studies had a follow-up period longer than 1 year. Among those that had a longer follow-up period, many were from the Transcend(Implantable gastric Stimulation) device group and maintained significant weight loss. Other significant results included changes in appetite/satiety, gastric emptying rate, blood pressure and neurohormone levels or biochemical markers such as ghrelin or HbA1 c respectively. CONCLUSION: GES holds great promises to be an effective obesity treatment. However, stronger evidence is required through more studies with a standardized way of carrying out trials and reporting outcomes, to determine the long-term effect of GES on obesity.

关键词： gastric electrical stimulation TANTALUS system Transcend implantable gastric stimulator Retrograde gastric electrical stimulation gastric vagal nerve stimulation gastric pacing EMPOWER trial Dual-lead implantable gastric electrical stimulation trial Laparoscopic obesity stimulation survey Screened health assessment and pacer evaluation

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