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Association of serum pepsinogen with degree of gastric mucosal atrophy in an asymptomatic population

World Journal of Clinical Cases 2021年第31期9卷 9431-9439页

作者： Hao-Lei Cai Yu-Ling Tong Department of Surgery The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina International Healthcare Center The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina

BACKGROUND Atrophic gastritis is a precancerous lesion of the *** has been reported that pepsinogen(PG)can reflect the morphology and function of the gastric mucosa,and it is therefore used as a marker for the early diagnosis of atrophic *** To evaluate the diagnostic value of serum PG for degree of gastric mucosal atrophy in asymptomatic Chinese upon physical *** Medical data were collected from subjects who underwent transnasal gastroscopy between October 2016 and October *** each study subject,serum PG levels and presence of Helicobacter pylori(***)infection were *** was evaluated using the Operative Link for Gastritis Assessment(OLGA)classification and Operative Link on gastric Intestinal Metaplasia Assessment(OLGIM)*** statistical analyses were carried out using SPSS statistical *** A total of 2256 subjects were enrolled and 1922 cases were finally included in the *** on the OLGA grading system,the levels of PGI were slightly decreased,while those of PGII were slightly *** PGI/PGII ratio(PGR)was reduced with increasing *** association between PG and OLGA grading was higher compared with that between PG and the OLGIM grading *** with the OLGA-0 group,a statistically significant difference was observed in the mean age of OLGA-Ⅰ,Ⅲ,and Ⅳ groups(Pgastric mucosal atrophy in asymptomatic subjects.

关键词： Pepsinogen Helicobacter pylori Operative Link for Gastritis Assessment Atrophic gastritis gastric mucosal atrophy Biomarker

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