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Acupuncture and Moxibustion in Treating gastric diseases

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Acupuncture and Moxibustion in Treating Gastric Diseases

Susceptibility to Allitridi of Helicobacter Pyiori with Different Genotypes in gastric diseases

新时代新思维新跨越新发展——2019中国针灸学会年会暨40周年回顾

作者： OUYANG Lizhi LIU HuiJuan WANG Jing LI Mingyu ZHOU Wei CHANG Xiaorong College of Acupuncture and Moxibustion and Massage Hunan University of Chinese Medicine Teaching and Research Office of Acupuncture and Moxibustion Hunan University of Chinese Medicine

In recent decades, Acupuncture and Moxibustion have been widely used in clinic all over the world, and play an increasingly important role in the treatment of clinical diseases[1]. Although pain was adominant focus on acupuncture and moxibustion research consistently, other topics of disease gained more attention during recent years[2]. A large number of acupuncture and moxibustion experts dedicated to the treat research of gastric diseases and have made some progress. This paper aims to review and analyze literature, summarize theresearch progress of acupuncture and moxibustion in the treatment of gastric diseases, so as to provide a basis for clinical gastric diseases treating with acupuncture and moxibustion and improve clinical practice.

关键词： Acupuncture Moxibustion gastric diseases

来源： cnki会议评论

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Chinese Journal of Cancer Research 2008年第4期20卷 268-273页

作者：王莹刘博宫月华袁媛 Cancer Institute The First Affiliated HospitalChina Medical University Department of Thoracic Surgery General Hospital of the Shenyang CommandPLA

Objective： To investigate the difference in susceptibilities to allitridi of Helicobacter pylori （***） strains in different gastric diseases and the associations with different genotypes. Methods： *** strains were isolated from gastric antral biopsy specimens and identified. DNA was isolated from *** strains. Different genotypes were determined by polymerase chain reaction（PCR）, and the allitridi MICs were determined by agar dilution methods. MIC50 was calculated. Results： The susceptibilities of H, pylori strains varied among different gastric diseases. *** strains in superficial gastritis were significantly more susceptible to allitridi than those in atrophic gastritis （relative median potency was 0.49, 95% confidence interval was from 0.24 to 0.80）, strains in superficial gastritis were significantly more susceptible than those in gastric cancer （relative median potency was 0.32, 95% confidence interval was from 0.06 to 0.68） and strains in atrophic gastritis were significantly more susceptible than those in gastric cancer（relative median potency was 0.16, 95% confidence interval was from 0.02 to 0.40）. The susceptibilities of *** strains with different genotypes varied among different gastric diseases. In atrophic gastritis, strains with vacAsl＋ were significantly more susceptible to allitridi than those with vacAsl（relative median potency was 0.21, 95% confidence interval was from 0.04 to 0.73）. In gastric cancer, strains with vacAmlb＋ were significantly more susceptible than those with vacAmlb-（relative median potency was 0.07, 95% confidence interval was from 0.03 to 0.49）. Conclusion： The vacA genotypes play an important role in the susceptibility to allitridi in different gastric diseases.

关键词： gastric diseases H.pylori, vacA Susceptibility

Helicobacter pylori and gastric cancer: Indian enigma

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World Journal of Gastroenterology 2014年第6期20卷 1503-1509页

作者： Vatsala Misra Renu Pandey Sri Prakash Misra Manisha Dwivedi Department of Pathology Moti Lal Nehru Medical College Pandey Research 3312 Jackson Blvd Department of Gastroenterology and Hepatology MLN Medical College

Helicobacter pylori (H. pylori) is a gram negative microaerophilic bacterium which resides in the mucous linings of the stomach. It has been implicated in the causation of various gastric disorders including gastric cancer. The geographical distribution and etiology of gastric cancer differ widely in different geographical regions and H. pylori, despite being labeled as a grade I carcinogen, has not been found to be associated with gastric cancer in many areas. Studies in Asian countries such as Thailand, India, Bangladesh, Pakistan, Iran, Saudi Arabian countries, Israel and Malaysia, have reported a high frequency of H. pylori infection co-existing with a low incidence of gastric cancer. In India, a difference in the prevalence of H. pylori infection and gastric cancer has been noted even in different regions of the country leading to a puzzle when attempting to find the causes of these variations. This puzzle of H. pylori distribution and gastric cancer epidemiology is known as the Indian enigma. In this review we have attempted to explain the Indian enigma using evidence from various Indian studies and from around the globe. This review covers aspects of epidemiology, the various biological strains present in different parts of the country and within individuals, the status of different H. pylori-related diseases and the molecular pathogenesis of the bacterium.

关键词： gastric cancer gastric diseases Helicobacter pylori p53 mutation Carcinogen

Effect of Helicobacter pylori on gastric epithelial cells

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World Journal of Gastroenterology 2014年第36期20卷 12767-12780页

作者： Shatha Alzahrani Taslima T Lina Jazmin Gonzalez Irina V Pinchuk Ellen J Beswick Victor E Reyes Department of Microbiology and Immunology University of Texas Medical Branch Galveston TX 77555 United States MSIII School of Medicine University of Texas Medical Branch Galveston TX 77555 United States Department of Internal Medicine University of Texas Medical Branch Galveston TX 77555 United States Departments of Molecular Genetics and Microbiology University of New Mexico Health Sciences Center Albuquerque NM 87131 United States Departments of Pediatricsand and Microbiology and Immunology University of Texas Medical Branch Galves-ton TX 77555 United States

The gastrointestinal epithelium has cells with features that make them a powerful line of defense in innate mucosal immunity. Features that allow gastrointestinal epithelial cells to contribute in innate defense include cell barrier integrity, cell turnover, autophagy, and innate immune responses. Helicobacter pylori (H. pylori) is a spiral shape gram negative bacterium that selectively colonizes the gastric epithelium of more than half of the world’s population. The infection invariably becomes persistent due to highly specialized mechanisms that facilitate H. pylori’s avoidance of this initial line of host defense as well as adaptive immune mechanisms. The host response is thus unsuccessful in clearing the infection and as a result becomes established as a persistent infection promoting chronic inflammation. In some individuals the associated inflammation contributes to ulcerogenesis or neoplasia. H. pylori has an array of different strategies to interact intimately with epithelial cells and manipulate their cellular processes and functions. Among the multiple aspects that H. pylori affects in gastric epithelial cells are their distribution of epithelial junctions, DNA damage, apoptosis, proliferation, stimulation of cytokine production, and cell transformation. Some of these processes are initiated as a result of the activation of signaling mechanisms activated on binding of H. pylori to cell surface receptors or via soluble virulence factors that gain access to the epithelium. The multiple responses by the epithelium to the infection contribute to pathogenesis associated with H. pylori.

关键词： Helicobacter pylori Apoptosis gastric epithelial cells Proinflammatory cytokines Chronic inflammation gastric diseases gastric cancer

Helicobacter pylori infection:How does age influence the inflammatory pattern?

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World Journal of Gastroenterology 2022年第4期28卷 402-411页

作者： Glauber Rocha Lima Araújo Hanna Santos Marques Maria Luísa Cordeiro Santos Filipe Antônio França daSilva Breno Bittencourt da Brito Gabriel Lima Correa Santos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900Brazil

The inflammatory pattern during Helicobacter pylori(***)infection is changeable and *** childhood,it is possible to observe a predominantly regulatory response,evidenced by high concentrations of key cytokines for the maintenance of Treg responses such as TGF-β1 and IL-10,in addition to high expression of the transcription factor *** the other hand,there is a predominance of cytokines associated with the Th1 and Th17 responses among ***-positive *** the last few years,the participation of the Th17 response in the gastric inflammation against *** infection has been highlighted due to the high levels of TGF-β1 and IL-17 found in this infectious scenario,and growing evidence has supported a close relationship between this immune response profile and unfavorable outcomes related to the ***,this cytokine profile might play a pivotal role in the effectiveness of *** *** is evident that age is one of the main factors influencing the gastric inflammatory pattern during the infection with ***,and understanding the immune response against the bacterium can assist in the development of alternative prophylactic and therapeutic strategies against the infection as well as in the comprehension of the pathogenesis of the outcomes related to that microorganism.

关键词： Helicobacter pylori Inflammation Treg response Th1 response Th17 response gastric diseases

Molecular cross-talk between Helicobacter pylori and human gastric mucosa

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World Journal of Gastroenterology 2011年第11期17卷 1383-1399页

作者： Vittorio Ricci Marco Romano Patrice Boquet Department of Physiology Human Physiology SectionUniversity of Pavia Medical School27100 PaviaItaly Department of Internal Medicine Chair of GastroenterologySecond University of Naples80131 NaplesItaly Department of Clinical Bacteriology Nice University Medical School06202 NiceFrance

Helicobacter pylori (***) has co-evolved with humans to be transmitted from person to person and to colonize the stomach persistently.A well-choreographed equilibrium between the bacterial effectors and host responses permits microbial persistence and health of the host,but confers a risk for serious diseases including gastric *** its long coexistence with humans,*** has developed complex strategies to limit the degree and extent of gastric mucosal damage and in? ammation,as well as immune effector *** present editorial thus aims to introduce and comment on major advances in the rapidly developing area of ***/human gastric mucosa interaction (and its pathological sequelae),which is the result of millennia of co-evolution of,and thus of reciprocal knowledge between,the pathogen and its human host.

关键词： Helicobacter pylori gastric mucosa Pathogen/host interaction gastric diseases Bacterial virulence factors CagA VacA

Epidemiology of Helicobacter pylori Infection and Related gastric Pathologies in Moroccan Population

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Journal of Life Sciences 2017年第5期11卷 211-218页

作者： Ghizlane Bounder Hasna Boura Saloua Nadifiyine Mohamed Reda Jouimyi Mariem Bensassi Maria Kadi Meriem Eljihad Wafa Badre Hakima Benomar Anass Kettani Halima Lebrazi Fatima Maachi Laboratory of Helicobacter Pylori and gastric Pathologies Institut Pasteur du Maroc Casablanca 20360 Morocco Laboratory of Biology and Health. Faculty of Sciences Ben M'sik University Hassan If Casablanca 20800 Morocco . Laboratory of Histo-Cytopathology Institut Pasteur du Maroc Casablanca 20360 Morocco Gastroenterology Department Ibn Rochd University Hospital Center Casablanca 20360 Morocco

Helicobacter pylori （H. pylori） colonize the gastric mucosa of 50% of the world＇s population. This infection is closely associated with the development of peptic ulcer disease and gastric cancer. The present study was conducted to assess the prevalence of H, pylori infection in Moroccan population and the risk to develop gastric precancerous lesions and gastric cancer. Totally, 298 patients were enrolled, 68 of asymptomatic subjects and 230 of patients with gastric diseases. Histological examination was effected to diagnostic gastric lesions and to detect H. pylori. ELISA was used to determine H. pylori status of patients. The prevalence of H. pylori within asymptomatic and symptomatic subjects was observed higher. A significant relationship was detected between H. pylori infection and the risk of gastric diseases （p-value 〈 0.0001）. A meaningful association between chronic gastritis increasing and age was observed （p-value = 0.03）. The risk to develop gastric cancer among infected patients was observed elevated with rate of 9%. Our results showed a high prevalence of H. pylori in both asymptomatic and gastric diseases patients. We noticed that chronic gastric infection increases with age. We remarked also that the risk to develop gastric cancer among infected patients was elevated in our population.

关键词： Helicobacterpylori prevalence Moroccan population gastric diseases gastric cancer.

Diagnostic advances of artificial intelligence and radiomics in gastroenterology

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Artificial Intelligence in Gastroenterology 2020年第2期1卷 37-50页

作者： Pei Feng Zhen-Dong Wang Wei Fan Heng Liu Jing-Jing Pan Department of Radiology PLA Rocket Force Characteristic Medical CenterBeijing 100088China Department of Ultrasound Beijing Sihui Hospital of Traditional Chinese MedicineBeijing 100022China

Traditional medical imaging,including ultrasound,computed tomography,magnetic resonance imaging,or positron emission tomography,remains widely used diagnostic modalities for gastrointestinal diseases at *** modalities are used to assess changes in morphology,attenuation,signal intensity,and enhancement *** tumors,especially malignant tumors,are commonly seen in clinical practice with an increasing number of deaths each *** the imaging manifestations of different diseases usually overlap,accurate early diagnosis of tumor lesions,noninvasive and effective evaluation of tumor staging,and prediction of prognosis remain ***,traditional medical images contain a great deal of important information that cannot be recognized by human eyes but can be extracted by artificial intelligence(AI)technology,which can quantitatively assess the heterogeneity of lesions and provide valuable information,including therapeutic effects and patient *** the development of computer technology,the combination of medical imaging and AI technology is considered to represent a promising field in medical image *** new emerging field is called“radiomics”,which makes big data mining and extraction from medical imagery possible and can help clinicians make effective decisions and develop personalized treatment ***,AI and radiomics have been gradually applied to lesion detection,qualitative and quantitative diagnosis,histopathological grading and staging of tumors,therapeutic efficacy assessment,and prognosis *** this minireview,we briefly introduce the basic principles and technology of ***,we review the research and application of AI and radiomics in gastrointestinal diseases,especially diagnostic advancements of radiomics in the differential diagnosis,treatment option,assessment of therapeutic efficacy,and prognosis evaluation of esophageal,gastric,hepatic,pancreatic,and colorect

关键词： Artificial intelligence Radiomics Texture analysis Gastroenterology Esophageal disease gastric diseases Hepatic disease