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gamma-glutamyl transpeptidase to Platelet Ratio Predicts Liver Injury in Hepatitis B e Antigen-negative Chronic Hepatitis B Patients With Normal Alanine Aminotransferase

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 247-253页

作者： Xiang-An Zhao Jian Wang Jie Wei Jiacheng Liu Guangmei Chen Li Wang Guiyang Wang Juan Xia Weihua Wu Shengxia Yin Xin Tong Xiaomin Yan Weimao Ding Xiaoxing Xiang Rui Huang Chao Wu Department of Gastroenterology Northern Jiangsu People’s HospitalClinical Medical College of Yangzhou UniversityYang-zhouJiangsuChina Department of Infectious Diseases Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjingJiangsuChina Department of Infectious Diseases Nanjing Drum Tower Hospital Clini-cal College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingJiangsuChina Department of Infectious Diseases Affiliated Hospital of Nanjing University of Chinese MedicineNanjingJiangsuChina Department of Hepatology Huai’an No.4 People’s HospitalHuai’anJiangsuChina

Background and Aims:Chronic hepatitis B virus(HBV)infection is a serious health problem *** liver injury in patients with hepatitis B e antigen(HBeAg)-negative chronic hepatitis B(CHB)with detectable HBV DNA and normal alanine aminotransferase(ALT)is crucial to guide their clinical *** aimed to investigate the stages of liver inflammation and fibrosis as well as the predictive accuracy of gamma-glutamyl transpepti-dase-to-platelet ratio(GPR)in these ***:A total of 184 treatment-naïve HBeAg-negative CHB pa-tients with detectable HBV DNA and normal ALT were *** Scheuer scoring system was used to classify liver inflammation and ***:The distribution of patients with different liver inflammation grades were as follows:G0,0(0%);G1,97(52.7%);G2,68(37.0%);G3,12(6.5%);and G4,7(3.8%).The distribution of patients with different liver fibrosis stages were as follows:S0,22(12.0%);S1,72(39.1%);S2,42(22.8%);S3,19(10.3%);and S4,29(15.8%).The areas under the re-ceiver operating characteristic(AUROC)curves of GPR in predicting significant inflammation,severe inflammation,and advanced inflammation were 0.723,0.895,and 0.952,*** accuracy of GPR was significantly superior to that of ALT in predicting liver *** AUROCs of GPR in predicting significant fibrosis,severe fibrosis,and cirrhosis were 0.691,0.780,and 0.803,*** predictive accuracy of GPR was significantly higher than that of aminotransferase-to-platelet ratio index(APRI)and fibrosis index based on four factors(FIB-4)in identifying advanced fibrosis and cirrhosis,and it was superior to FIB-4 but comparable to APRI in identifying significant ***:Nearly half of the HBeAg-negative CHB patients with detectable HBV DNA and normal ALT levels had significant liver inflammation or *** can serve as an accurate predictor of liver inflammation and fibrosis in these patients.

关键词： Chronic hepatitis B Liver injury gamma-glutamyl transpeptidase Platelet

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Helicobacter pylori gamma-glutamyl transpeptidase and its pathogenic role

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World Journal of Gastroenterology 2014年第3期20卷 630-638页

作者： Vittorio Ricci Maria Giannouli Marco Romano Raffaele Zarrilli Department of Molecular Medicine Human Physiology SectionUniversity of Pavia Medical School Department of Public Health Hygiene SectionUniversity of Naples "Federico Ⅱ" Department of Clinical and Experimental Medicine Chair of GastroenterologySecond University of Naples CEINGE Biotecnologie Avanzate

Helicobacter pylori(***)gamma-glutamyl transpeptidase(GGT)is a bacterial virulence factor that converts glutamine into glutamate and ammonia,and converts glutathione into glutamate and *** GGT causes glutamine and glutathione consumption in the host cells,ammonia production and reactive oxygen species *** products induce cell-cycle arrest,apoptosis,and necrosis in gastric epithelial *** GGT may also inhibit apoptosis and induce gastric epithelial cell proliferation through the induction of cyclooxygenase-2,epidermal growth factor-related peptides,inducible nitric oxide synthase and *** GGT induces immune tolerance through the inhibition of T cell-mediated immunity and dendritic cell *** effect of GGT on *** colonization and gastric persistence are also discussed.

关键词： Helicobacter pylori gamma-glutamyl transpeptidase Bacterial virulence factor Gastric epithelial cell damage T cell-mediated immunity

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Relationship between alcohol consumption and clinical manifestation of patients with fatty liver:a single-center study

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Hepatobiliary & Pancreatic Diseases International 2011年第3期10卷 276-279页

作者： International Health Care Center (Wang XF) and Department of Gastroenterology (Yue M),First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China [a] International Health Care Center First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China [b] Department of Gastroenterology First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China

BACKGROUND:Fatty liver is a common chronic liver disease *** is associated with an increasing morbidity in China in recent *** aim of this study was to analyze the effect of drinking alcohol on the hemoglobin and biochemical values of patients with fatty ***:We investigated the clinical and laboratory data of 669 patients with fatty *** the 669 patients,166 consumed alcohol more than 60 g per week for at least 2 years,and 503 did not have a history of long-term alcohol *** further analyzed the relationship between alcohol consumption and clinical characteristics of these ***:The values of aspartate transaminase (AST),gammaglutamyl transpeptidase (GGT),and hemoglobin in the long-term consumption group were significantly higher than those in the non long-term consumption group (P<0.05).In the patients without long-term alcohol consumption,the values of GGT and hemoglobin in patients with light alcohol consumption were significantly higher than those in non alcohol consumers (P<0.05).CONCLUSION:Alcohol consumption is associated with significantly increased values of AST,GGT,and hemoglobin in patients with fatty liver,suggesting their potential roles in hepatic steatosis.

关键词： alcohol consumption fatty liver hemoglobin aspartate transaminase gamma-glutamyl transpeptidase

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