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γ-glutamyl transferase-to-platelet ratio based nomogram predicting overall survival of gallbladder carcinoma

World Journal of Gastrointestinal Oncology 2020年第9期12卷 1014-1030页

作者： Le-Jia Sun Ai Guan Wei-Yu Xu Mei-Xi Liu Huan-Huan Yin Bao Jin Gang Xu Fei-Hu Xie Hai-Feng Xu Shun-Da Du Yi-Yao Xu Hai-Tao Zhao Xin Lu Xin-Ting Sang Hua-Yu Yang Yi-Lei Mao Department of Liver Surgery Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of Clinical Medicine Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of General Surgery Beijing Friendship HospitalCapital Medical UniversityBeijing 100730China

BACKGROUND Gallbladder carcinoma(GBC)carries a poor prognosis and requires a prediction ***-glutamyl transferase–to–platelet ratio(GPR)is a recently reported cancer prognostic *** the mechanism for the relationship between GPR and poor cancer prognosis remains unclear,studies have demonstrated the clinical effect of both gamma-glutamyl transferase and platelet count on GBC and related gallbladder *** To assess the prognostic value of GPR and to design a prognostic nomogram for *** The analysis involved 130 GBC patients who underwent surgery at Peking Union Medical College Hospital from December 2003 to April *** patients were stratified into a high-or low-GPR *** predictive ability of GPR was evaluated by Kaplan–Meier analysis and a Cox regression *** developed a nomogram based on GPR,which we verified using calibration *** nomogram and other prognosis prediction models were compared using timedependent receiver operating characteristic curves and the concordance *** Patients in the high-GPR group had a higher risk of jaundice,were older,and had higher carbohydrate antigen 19-9 levels and worse postoperative *** analysis revealed that GPR,age,body mass index,tumor–node–metastasis(TNM)stage,jaundice,cancer cell differentiation degree,and carcinoembryonic antigen and carbohydrate antigen 19-9 levels were related to overall survival(OS).Multivariate analysis confirmed that GPR,body mass index,age,and TNM stage were independent predictors of poor *** curves were highly consistent with actual *** of timedependent receiver operating characteristic curves and the concordance index showed advantages for the nomogram over TNM *** GPR is an independent predictor of GBC prognosis,and nomogram-integrated GPR is a promising predictive model for OS in GBC.

关键词： gamma-glutamyl transferase-to-platelet ratio Gallbladder carcinoma Prognosis Nomogram Tumor-node-metastasis Patient management

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