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Research on Using IMRT Plan for Preoperative Rectal Cancer Patients

International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2020年第4期9卷 165-177页

作者： Quang Bui Vinh Soai Dang Quoc Cuong Bui Xuan Toan Hoang Van Truong Vu Radiotherapy Department Hanoi Oncology Hospital Hanoi Vietnam Medicinal Supplies-Medical Physics Division Hanoi Oncology Hospital Hanoi Vietnam

Aims: Research the possibility of using IMRT for rectal cancer patients in preoperative radiotherapy. Methods and Material: The research object is the preoperative radiotherapy plan for rectal cancer patients. The research group made two plans (IMRT, 3DCRT) for each image series of 34 rectal cancer patients who have received preoperative radiotherapy in Hanoi Oncology Hospital;and then compared the dose distribution on PTV, bladder, intestine, femoral bones, the average MU, and QA results of two types of plan. Results: The 95% isodose line and 50% isodose of IMRT plan are closer than those of 3DCRT plan. The average dose of PTV in IMRT plan and 3DCRT plan are 5006 ± 23 cGy and 5036 ± 42 cGy, respectively. The HTCI and HI values of IMRT and 3D plan are 0.97 ± 0.026 and 5.37 ± 1.32;1.00 ± 0.003 and 7.08 ± 0.88. About the dose of organ at risk: The maximum dose, average dose on the right, left femoral head in the IMRT plan are less than those values in the 3DCRT plan (6.2 Gy, 6 Gy, 7.4 Gy, 9 Gy, respectively). The maximum dose and average dose on the bladder of the IMRT plan are smaller than those values of the 3DCRT plan (5.3 Gy, 1.5 times, respectively). The maximum dose and average dose of intestine in the IMRT plan was less than those values in the 3DCRT plan (4.3 Gy, 1.54 times, respectively). The MU number of IMRT plan is 1.5 times bigger than that of 3DCRT plan. gamma index of IMRT plan is better than that of 3DCRT plan (99% compared with 97%). Conclusions: Using IMRT plan in preoperative radiotherapy for rectal cancer patients can still ensure covered PTV as well as the 3D PLAN. Furthermore, the dose of PTV in the IMRT plan is more uniform than those in the 3D plan, and the dose effect on the OAR surrounding PTV is much lower than when using the 3D plan. When IMRT plan were used to treat the preoperative rectal cancer patients, the LINAC took more time than when using 3DCRT plan.

关键词： Rectal Cancer Preoperative Radiotherapy IMRT HI HTCI gamma index

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Enhancing Precision in Radiotherapy Delivery: Validating Monte Carlo Simulation Models for 6 MV Elekta Synergy Agility LINAC Photon Beam Using Two Models of the GAMOS Code

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World Journal of Nuclear Science and Technology 2024年第2期14卷 146-163页

作者： Nogaye Ndiaye Oumar Ndiaye Papa Macoumba Faye Kodjo Joël Fabrice N’Guessan Djicknack Dione Khady Sy Moussa Hamady Sy Jean Paul Latyr Faye Alassane Traoré Ababacar Sadikhe Ndao Institute of Applied Nuclear Technology University Cheikh Anta Diop Dakar Senegal International Cancer Center of Dakar Dakar Senegal Department of Physics Faculty of Sciences and Technology University Cheikh Anta Diop Dakar Senegal

The most crucial requirement in radiation therapy treatment planning is a fast and accurate treatment planning system that minimizes damage to healthy tissues surrounding cancer cells. The use of Monte Carlo toolkits has become indispensable for research aimed at precisely determining the dose in radiotherapy. Among the numerous algorithms developed in recent years, the GAMOS code, which utilizes the Geant4 toolkit for Monte Carlo simula-tions, incorporates various electromagnetic physics models and multiple scattering models for simulating particle interactions with matter. This makes it a valuable tool for dose calculations in medical applications and throughout the patient’s volume. The aim of this present work aims to vali-date the GAMOS code for the simulation of a 6 MV photon-beam output from the Elekta Synergy Agility linear accelerator. The simulation involves mod-eling the major components of the accelerator head and the interactions of the radiation beam with a homogeneous water phantom and particle information was collected following the modeling of the phase space. This space was po-sitioned under the X and Y jaws, utilizing three electromagnetic physics mod-els of the GAMOS code: Standard, Penelope, and Low-Energy, along with three multiple scattering models: Goudsmit-Saunderson, Urban, and Wentzel-VI. The obtained phase space file was used as a particle source to simulate dose distributions (depth-dose and dose profile) for field sizes of 5 × 5 cm2 and 10 × 10 cm2 at depths of 10 cm and 20 cm in a water phantom, with a source-surface distance (SSD) of 90 cm from the target. We compared the three electromagnetic physics models and the three multiple scattering mod-els of the GAMOS code to experimental results. Validation of our results was performed using the gamma index, with an acceptability criterion of 3% for the dose difference (DD) and 3 mm for the distance-to-agreement (DTA). We achieved agreements of 94% and 96%, respective

关键词： GAMOS Monte Carlo LINAC Radiotherapy Dose Distribution Phase Space gamma index 6 MV Photon Beam

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Feasibility of Estimating Patient-Specific Dose Verification Results Directly from Linear Accelerator Log Files in Volumetric Modulated Arc Therapy

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2016年第4期5卷 317-328页

作者： Kengo Kosaka Masao Tanooka Hiroshi Doi Hiroyuki Inoue Kazuo Tarutani Hitomi Suzuki Yasuhiro Takada Masayuki Fujiwara Norihiko Kamikonya Shozo Hirota Department of Radiology Hyogo College of Medicine Nishinomiya Japan Department of Radiological Technology Hyogo College of Medicine College Hospital Nishinomiya Japan

The feasibility of estimating patient-specific dose verification results directly from linear accelerator (linac) log files has been investigated for prostate cancer patients who undergo volumetric modulated arc therapy (VMAT). Twenty-six patients who underwent VMAT in our facility were consecutively selected. VMAT plans were created using Monaco treatment planning system and were transferred to an Elekta linac. During the beam delivery, dynamic machine parameters such as positions of the multi-leaf collimator and the gantry were recorded in the log files;subsequently, root mean square (rms) values of control errors, speeds and accelerations of the above machine parameters were calculated for each delivery. Dose verification was performed for all the plans using a cylindrical phantom with diodes placed in a spiral array. The gamma index pass rates were evaluated under 3%/3 mm and 2%/2 mm criteria with a dose threshold of 10%. Subsequently, the correlation coefficients between the gamma index pass rates and each of the above rms values were calculated. Under the 2%/2 mm criteria, significant negative correlations were found between the gamma index pass rates and the rms gantry angle errors (r = 0.64, p gamma index pass rates. We suggest that the VMAT quality assurance (QA) results can be directly estimated from the log file thereby providing potential to simplify patient-specific prostate VMAT QA procedure.

关键词： Radiotherapy VMAT Log File Patient Specific QA Correlation gamma index

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Evaluation of Patient-Specific Quality Assurance for Carbon Ion Radiotherapy Using Full Energy Scanning Method at QST Hospital

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2022年第4期11卷 200-209页

作者： Asami Inomata Masashi Katsumata Sung Hyun Lee Yui Suzuki Takeo Nakajima Wataru Furuichi Keishi Yamaoka Atsushi Yamamoto Hideyuki Mizuno Ryosuke Kohno Accelerator Engineering Corporation Chiba Japan Department of Accelerator and Medical Physics National Institutes for Quantum and Radiological Science and Technology Chiba Japan Department of Heavy Particle Medical Science Graduate School of Medical Science Yamagata University Yamagata Japan QST Hospital National Institutes for Quantum and Radiological Science and Technology Chiba Japan Department of Radiological Sciences International University of Health and Welfare Tochigi Japan

Purpose: Patient-specific QA (PSQA) measurements for carbon ion radiotherapy (CIRT) are critical components of processes designed to identify discrepancies between calculated and delivered doses. We report the results of PSQA conducted at the QST Hospital during the period from September 2017 to March 2018. Methods: We analyzed PSQA results for 1448 fields for 10 disease sites with various target volumes, target depths and number of energy layers. For the PSQA, all the planned beams were recalculated on a water phantom with treatment planning software. The recalculated dose distributions were compared with the measured distributions using a 2D ionization chamber array at three depths, including 95% of the area of the prescription dose. These recalculated dose distributions were evaluated using the 3%/3mm gamma index with a passing threshold of 90%. Results: The passing rates for prostate, head and neck, and bone and soft tissue were 96.8%, 99.3%, and 91.7%, respectively. Additionally, 94.7% of lung plans with low energy beams passed. Overall, the CIRT in the QST Hospital reached a high passing rate of more than 95%. Although the remaining 5% failed to pass, there was no dependence between measurement depth and disease sites in these failures. Conclusion: Using PSQA measurements, we confirmed consistency between the planned and delivered doses for CIRT using the full energy scanning method.

关键词： Carbon Ion Radiotherapy Full Energy Scanning Patient-Specific Quality Assurance gamma index

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