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Antioxidant Activity and Phytochemical Screening in Acacia rigidula Benth. Leaves

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Advances in Bioscience and Biotechnology 2024年第1期15卷 15-38页

作者： Aneth Ochoa-Negrete Rene Rangel Marcus Antonius Ynalvez Ruby A. Ynalvez Department of Biology and Chemistry Texas A&M International University Laredo TX USA Department of Social Sciences Texas A&M International University Laredo TX USA

This study aimed to compare the total phenolic content (TPC) and antioxidant activities of A. rigidula extracts. It also aimed to identify phenolic acids present in the extracts. The 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and ferric thiocyanate lipid peroxidation antioxidant assays were performed. High performance liquid chromatography was used to identify phenolic acids. There was no solvent effect on TPC nor on scavenging activities, and inhibition of lipid peroxidation (p > 0.05) among solvent extracts. On the other hand, 1:1:3 water: acetone: methanol extract (10.22 mg GAE/g sample) had significantly higher reducing potential than 50% ethanol extract (EE) (9.259 mg GAE/g sample) (p 0.05). Phenolic fraction designated as fraction 4 had the highest antioxidant activity (p gallic, caffeic, vanillic, p-coumaric, salicylic acids and vanillin.

关键词： Acacia Plant Extract Antioxidant Activity Total Phenolic acid HPLC gallic acid

Exosome-functionalized magnesium-organic framework-based scaffoldswith osteogenic, angiogenic and anti-inflammatory properties foraccelerated bone regeneration

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Bioactive Materials 2022年第12期7卷 26-41页

作者： Yue Kang Chang Xu Ling’ao Meng Xufeng Dong Min Qi Daqing Jiang Department of Breast Surgery Cancer Hospital of China Medical University44 Xiaoheyan RoadDadong DistrictShenyang110042PR China School of Materials Science and Engineering Dalian University of Technology2 Linggong RoadGanjingzi DistrictDalian116024China

Exosomes derived from human adipose-derived stem cells (hADSCs-Exos) have shown potential as an effectivetherapeutic tool for repairing bone defects. Although metal-organic framework (MOF) scaffolds are promisingstrategies for bone tissue regeneration, their potential use for exosome loading remains unexplored. In this study,motivated by the potential advantages of hADSCs-Exos and Mg-GA MOF, we designed and synthesized anexosome-functionalized cell-free PLGA/Mg-GA MOF (PLGA/Exo-Mg-GA MOF) scaffold, taking using of thebenefits of hADSCs-Exos, Mg2+, and gallic acid (GA) to construct unique nanostructural interfaces to enhanceosteogenic, angiogenic and anti-inflammatory capabilities simultaneously. Our in vitro work demonstrated thebeneficial effects of PLGA/Exo-Mg-GA MOF composite scaffolds on the osteogenic effects in human bonemarrow-derived mesenchymal stem cells (hBMSCs) and angiogenic effects in human umbilical endothelial cells(HUVECs). Slowly released hADSCs-Exos from composite scaffolds were phagocytosed by co-cultured cells,stabilized the bone graft environment, ensured blood supply, promoted osteogenic differentiation, and acceleratedbone reconstruction. Furthermore, our in vivo experiments with rat calvarial defect model showed thatPLGA/Exo-Mg-GA MOF scaffolds promoted new bone formation and satisfactory osseointegration. Overall, weprovide valuable new insights for designing exosome-coated nanocomposite scaffolds with enhanced osteogenesisproperty.

关键词： Metal-organic framework Exosomes Magnesium ions gallic acid Osteogenesis Angiogenesis Anti-inflammation Rat calvarial defect model Bone regeneration

Chemical composition of Galla chinensis extract and the effect of its main component(s) on the prevention of enamel demineralization in vitro

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International Journal of Oral Science 2012年第3期4卷 146-151页

作者： Xue-Lian Huang Ming-Dong Liu Ji-Yao Li Xue-Dong Zhou Jacob M ten Cate State Key Laboratory of Oral Diseases Sichuan UniversityChengduChina West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Cariology Endodontology Pedodontology Academic Centre for Dentistry Amsterdam(ACTA)University of Amsterdam and Free University AmsterdamAmsterdamThe Netherlands Department of Analytical Toxicology West China School of Preclinical and Forensic MedicineSichuan UniversityChengduChina

To determine the chemical composition of Galla chinensisextract （GCE） by several analysis techniques and to compare the efficacy of GCE and its main component（s） in inhibition of enamel demineralization, for the development of future anticaries agents, main organic composition of GCE was qualitatively determined by liquid chromatography-time of flight-mass spectrometry （LC-TOF-MS） and quantified by high-performance liquid chromatography-diode array detector （HPLC-DAD）. Inorganic ions were tested by inductively coupled plasma-atomic emission spectroscopy and F was especially measured by ion chromatography. Then, bovine enamel blocks were randomly divided into four treatment groups and were subjected to a pH-cycling regime for 12 times. Each cycle included 5-min applications with one of four treatments： 4g.L-1 GCE solution, 4g.L-1 gallic acid （GA） solution, I g.L-1 NaF solution （positive control）, deionized water （DDW, negative control）, and then 60-min application in pH 5.0 acidic buffer and 5-min application in neutral buffer. acidic buffers were retained for calcium analysis. The main organic composition of GCE were GA and its isomer, and, to a lesser extent, small molecule gallotannins. The content of GA in GCE was 71.3%±0.2% （w/w）. Inorganic ions were present in various amounts, of which Ca was （136±2.82） μg.g-1, and Zn was （6.8±0.1） μg.g-1. No F was detected in GCE. in pH cycling, GA showed an effect similar to GCE in inhibiting enamel demineralization （P〉0.05）. GA was found to be the main effective, demineralization inhibiting component of GCE and could be a promising agent for the development of anticaries agents.

关键词： active component Galla chinensis gallic acid composition dental caries

3D Tungsten Trioxide Nanosheets as Optoelectronic Materials for On-chip Quantification of Global Antioxidant Capacity

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Chemical Research in Chinese Universities 2021年第3期37卷 763-771页

作者： DAI Mengjiao MA Weiguang HAN Fangjie HAN Dongfang HAN Lipeng WANG Wei ZHAO Bolin HAN Dongxue NIU Li WANG Zhenxin State Key Laboratory of Electroanalytical Chemistry c/o Engineering Laboratory for Modern Analytical TechniquesChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022P.R.China University of Science and Technology of China Hefei230026P.R.China Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023P.R.China Center for Advanced Analytical Science c/o School of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhou510006P.R.China

The photoelectrochemical properties of semiconductors mainly depend on the size and shape of the corresponding ***,3D WO3 nanosheets were controllably synthesized with the aid of polyethyleneimine,which presents enhanced photocurrent *** on this excellent photoelectrochemical property,a photoelectrochemical chip was prepared by lithography technology for the smart monitoring of the antioxidant capacity(AC)in red wine and exhibits a series of advantages including rapid response time,high sensitivity,and long-lasting *** mechanism of the present photoelectrochemical sensing was explored and shows a single electron transfer ***,only 200µL of samples are required for one testing,which demonstrates that the present photoelectrochemical chip can be potentially integrated with a portable commercial device(such as a mobile phone)for further research and development of food and drug supervision.

关键词： 3D tungsten trioxide nanosheet Photoelectrochemical chip Antioxidant capacity assessment Red wine assessment gallic acid

Novel enzymatically crosslinked chitosan hydrogels with free-radical-scavenging property and promoted cellular behaviors under hyperglycemia

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Progress in Natural Science:Materials International 2020年第5期30卷 661-668页

作者： Dieu Linh Tran Phuong Le Thi Thai Thanh Hoang Thi Ki Dong Park Department of Molecular Science and Technology Ajou University Biomaterials and Nanotechnology Research Group Faculty of Applied Sciences Ton Duc Thang University

The impairment of regenerative processes induced by high blood-glucose level(hyperglycemia) and excessive reactive oxygen species(ROS) contributes to the diabetic complication progression and development. In this study, an injectable, in situ crosslinkable chitosan hydrogel with ROS-scavenging capability was developed by conjugating gallic acid onto the chitosan backbone(CGA). We hypothesized that gallic acid serves as both antioxidant and crosslinking moieties to form hydrogel in situ by means of enzymatic crosslinking with horseradish peroxidase(HRP). The rapid gelation(from 30 s) was observed by vial tilting. The mechanical properties and microstructures of CGA hydrogels can be well controlled by varying the concentrations of H2O2. The ROSscavenging ability of these CGA hydrogels was demonstrated against DPPH radical, hydroxyl radical, and total reducing power. Notably, in an in vitro hyperglycemia environment, CGA hydrogels significantly improved the proliferation and migration of human dermal fibroblast cells, which are closely related to diabetic wound healing. These results suggest that CGA hydrogels have potential as advanced materials for the treatment of diabetes-related diseases via attenuating the excessive ROS production and improving cellular behaviors.

关键词： Chitosan gallic acid Injectable hydrogel Hyperglycemia Free-radical-scavenging

Nutritional, Textural, Sensory Properties and Storage Stability Evaluation of Newly Formulated Strawberry Bar

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Food and Nutrition Sciences 2023年第4期14卷 287-299页

作者： Nargis Akter Md. Sajib Al Reza Md. Esrafil Md. Al Amin Sonyia Akter Neaz Morshed Reza Md. Nazmul Huda Nasim Pratima Roy Dina Department of Food Technology and Nutritional Science Faculty of Life Science Mawlana Bhashani Science and Technology University Santosh Bangladesh Department of Biological Sciences Graduate School of Science Tokyo Metropolitan University Hachioji Japan Department of Chemistry and Biochemistry The University of Texas at Arlington Arlington USA

An analytical study was conducted to develop a strawberry bar and analysis of the nutritional quality and storage stability of a newly formulated strawberry bar. In proximate analysis moisture, ash, pH, acidity, vitamin C, total phenolic content, and antioxidant of strawberry pulp were found 82%, 0.5%, 2.57, 1.38%, 49 mg/100g, 0.33%, 75.17% whereas, in the strawberry bar, it was found 18%, 0.71%, 2.10, 1.10%, 22 mg/100g, 0.14%, 56.13% respectively. For textural properties analysis, the textural profile of the strawberry bar such as hardness, factorability, viscosity, cohesiveness, adhesiveness, springiness, gumminess, chewiness, probe diameter, threshold, filtering range of strawberry bar was found 5.538 × 104 N/m, 0.000 N/m2, 1.687 × 104 N/m2, 0.6636, 2.908 × 103 J/m3, 0.8664, 3.675 × 104 N/m2, 3.184 × 104 N/m2, 20.000 mm, 5 N, 0.4 N respectively whereas the maximum level was 17.4 N at 29.628 seconds and the minimum level was -5.3 N at 30.166 seconds. The sensory evaluation of the strawberry bar was conducted based on nine-point hedonic scales. The sensory evaluation results indicated that the appearance of the strawberry bar was liked very much and the taste, texture, color, aroma, and overall acceptability of the strawberry bar were liked moderately by panelists. In microbiological analysis, the Total Viable Count (TVC) and Total Coliform Count (TCC) of the strawberry bar were found safe levels for up to third days. But on the sixth day, the TCC of the strawberry bar was not found and the TVC of the strawberry bar was found 17 × 104 cfu/g respectively which is higher than the permitted value (Gulf Standard: 105 cfu/g). From the microbial point of view, the newly formulated strawberry bar was safe to consume for up to 3 days but not for 6 days.

关键词： Strawberry Pulp Strawberry Bar Antioxidant Sensory Evaluation Texture gallic acid

Phytochemical Study and Evaluation of the Antiradical Activity of Extracts of Oleaginous Seeds of Panda oleosa and Isolona hexaloba from Gabon

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Food and Nutrition Sciences 2022年第2期13卷 165-180页

作者： M.-A. N’negue ép Mezui-Mbeng Darina Medza Prosper Edou Engonga Ognane Bikoro Lié Lyne Mengome Nestor Engone Abougone Sophie Laboratory of Chemistry-Biochemistry of the Faculty of Medicine University of Health Sciences Libreville Gabon Institute of de Pharmacopoeia and Traditional Medicine (IPHAMETRA) National Center for Scientific and Technical Research (CENAREST) Department of Phytochemistry Libreville-Gabon Pharmacopée et Médecine Traditionnelle (IPHAMETRA) Centre National de la Recherche Scientifique et Technique (CENAREST) Département de Phytochimie Libreville Gabon Ecole Normale Supérieure Department of Physical Sciences Laboratoire Pluridisciplinaire des Sciences (LAPLUS) Libreville Gabon

Our study focused on phytochemical tests and evaluation of the anti-free radical activity of seed extracts of two oleaginous plants from Gabon used in traditional medicine or as condiments: Panda oleosa and Isolona hexaloba. The extraction was carried out by maceration with solvents of increasing polarity: cyclohexane, trichloroethylene, acetone, ethanol and finally distilled water. The total yields of the extracts are about 69.50% for Panda oleosa and 34.28% for Isolona hexaloba. The phytochemical tests carried out on the extracts of the seeds of Panda and Isolona highlight in both seeds the presence of alkaloids, polyphenols, triterpenes, carotenoids, reducing compounds, flavonoids, total sugars, coumarins, anthraquinones, free quinones, free anthracene derivatives, and terpenoids. Isolona seeds also contain leucoanthocyanins, sterols, cardiac glycosides and saponins. Phytochemical tests revealed the absence of tannins and mucilage in both seeds. The free radical scavenging activity was measured by scavenging the free radical cation of 2,2’-azino-bis[3-ethylbenzothiazoline-6-sulfonic acid] (ABTS-+) with gallic acid as the reference antioxidant. The results of the free radical scavenging activity of the aqueous and ethanolic extracts of both seeds showed that the aqueous extracts were more active than the ethanolic extracts. The IC50s of the aqueous and ethanolic extracts of Panda seeds are 40 and 60 μg·mL-1 respectively, and those of the aqueous and ethanolic extracts of Isolona are 37.5 and 95 μg·mL-1 respectively. gallic acid, the reference antioxidant (IC50 = 0.37 μg·mL-1) is about 10 times more active than the aqueous extracts of both seeds, 16 times more active than the ethanolic extract of Panda and 25 times more active than the ethanolic extract of Isolena.

关键词： Panda oleosa Isolona hexaloba Oleaginous Seeds Extracts Phytochemical Screening Antiradical Activity ABTS-+ gallic acid

Synthesis and Characterization of 1,4-Benzodioxane-6-Carboxylic acid Amide Analogs

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International Journal of Organic Chemistry 2022年第3期12卷 143-160页

作者： Nabil Idris Alan J. Anderson Oladapo Bakare Department of Chemistry Howard University Washington DC USA Department of Natural Sciences Bowie State University Bowie USA

A library of new 1,4-benzodioxane-6-carboxylic acid amide analogs was designed and synthesized. These analogs were obtained in six steps from gallic acid. Firstly, esterification of the commercially available gallic acid in methanol in the presence of sulfuric acid afforded methyl 3,4,5-trihydroxybenzoate (9) in satisfactory yield. The ester 9 was then reacted with an excess of 1,2-dibromoethane in the presence of K2CO3 in acetone to furnish the 6,8-disubstituted-1,4-benzodioxane (10) in 45% yield. The reaction of 10 with various mercaptans gave the sulfide derivative 11, 12, and 13 in moderate yield. Subsequent hydrolysis of the methyl ester in 13 followed by conversion to the acid chloride and reaction of the acid chloride intermediate with different commercially available primary and secondary amines gave the amide analogs 18 - 32 with an average yield of 43%. Conversion of the sulfide group in Compound 23 to Sulfoxide 33 or Sulfone 34 was accomplished by reaction with either 30% H2O2/TeO2 or 30% H2O2, respectively. The structures of the synthesized compounds were characterized using FTIR, 1H-NMR, 13C-NMR, and high-resolution ESI-MS.

关键词： gallic acid 1 4-Benzodioxane Derivatives Prostate Cancer Anticancer Drugs

Identified Analytical Profile for Microelements, Trace Metals, Amino acids and Screening of Anti-Diabetic Activity from Flower and Leaf Extracts of Moringa oleifera in Streptozotocin (STZ)-Induced Diabetic Rats

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Pharmacology & Pharmacy 2022年第6期13卷 149-163页

作者： Hemalatha Kamurthy Sirajunisa Talath Department of Pharmacognosy Acharya & BM Reddy College of Pharmacy Bangalore India Department of Pharmaceutical Chemistry RAK College of Pharmacy RAKMHSU Ras Al Khaimah UAE

Background: Moringa oleifera plant is popularly known for its rich phytoconstituents and nutritional value and important medicinal values in both traditional and modern systems of medicine. We explored the present study for measurements of microelements, amino acid, phenolic content in hydro-al-coholic flower and leaf extracts of Moringa oleifera along with anti-diabetic activity in Streptozotocin (STZ)-induced diabetic male Wistar rats. Methodology: The micronutrients were determined by using atomic absorption spectrophotometer at 285 nm and 422 nm for Calcium (Ca), phosphorus (P), Iron (Fe), and Zinc (Zn), etc. The trace elements were also measured by spectrophotometer. The essential amino acid was determined by using Amino acid analyser. The total phenolic content in hydro-alcoholic extracts (flower and leaf) M. oleifera measured the absorbance at 760 nm by UV spectrophotometer. The screening of anti-diabetic activity HAFE and HALE of Moringa oleifera at two different dose of 100 and 200 mg/kg b.w. for 21 days were performed by determining the changes in biochemical parameters. Result and Discussion: The results revels that the presence of micronutrients, trace elements and amino acids in both flower and leaf of M. oleifera. The hydrolaocholic extracts of HAFE and HALE at 200 mg/kg b.w. showed significant antidiabetic activity compared with standard Glibenclamide. Whereas dose at 100 mg/kg b.w. showed moderate activity. Conclusion: In conclusion, the M. oleifera exhibits more effectiveness against STZ-induced diabetes. The HAFE and HALF extracts exhibited significant anti-diabetic property and active components may be isolated and clinical studies is required for further evaluation. Because of the rich source of phytoconstients, nutritional elements will be helpful in processed food products as dietary supplements especially for malnutrition in children in the current era.

关键词： Moringa oleifera Microelements Nutritional Values gallic acid Amino acids Streptozotocin Glibenclamide