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Chemical Research in Chinese Universities 2021年第3期37卷 450-455页

作者： SONG Yudong HUANG Hui HE Dayong YANG Mei WANG Hao ZHANG Hao LI Jiali LI Yongxin WANG Ce College of Food Science and Engineering Jilin UniversityChangchun130025P.R.China Key Lab of Groundwater Resources and Environment of Ministry of Education College of New Energy and EnvironmentJilin UniversityChangchun130021P.R.China Alan G.MacDiarmid Institute College of ChemistryJilin UniversityChangchun130012P.R.China

gallic acid(GA)is a kind of natural polyphenolic compound,but its low aqueous solubility restricts its application in the fields of food and *** can form inclusion complexes with guest molecules(e.g.,essential oils,food supplements)through cavities with special properties to improve aqueous solubility,thermal stability,and bioavailability of guest *** this research,gallic acid/2-hydroxypropyl-β-cyclodextrin inclusion complexes(GA/2-HP-β-CD/ICs)were formed in a highly concentrated solution of 2-HP-β-***-free and uniform nanofibrous webs(GA/2-HP-β-CD/IC-NWs)were produced successfully by electrospun GA/HP-β-CD/IC aqueous *** initial molar ratio(GA:2-HP-β-CD=1:1)of GA/2-HP-β-CD/IC in the solutions was largely maintained in GA/2-HP-β-CD/*** aqueous solubility of GA was enhanced and GA/2-HP-β-CD/IC-NW has displayed fast dissolution ***,in comparison with GA powder,GA/2-HP-β-CD/IC-NW demonstrated improved antioxidant *** results suggested that GA/2-HP-β-CD/IC-NW have broad application prospects as orally fast dissolution systems for food supplements.

关键词： gallic acid 2-Hydroxypropyl-β-cyclodextrin Inclusion complex Electrospun Fast dissolution

gallic acid: A Potential Anti-Cancer Agent

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Chinese Journal of Integrative Medicine 2022年第7期28卷 661-671页

作者： JIANG Yuan PEI Jin ZHENG Yan MIAO Yu-jing DUAN Bao-zhong HUANG Lin-fang Key Laboratory of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People's Republic of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China State Key Laboratory of Southwestern Chinese Medicine Resources Pharmacy CollegeChengdu University of Traditional Chinese MedicineChengdu 611137China College of Pharmaceutical Science Dali UniversityDaliYunnan Province 761000China

Cancer is one of the most devastating diseases worldwide and definitive therapeutics for treating cancer are not yet available despite extensive research efforts. The key challenges include limiting factors connected with traditional chemotherapeutics, primarily drug resistance, low response rates, and adverse side-effects. Therefore, there is a high demand for novel anti-cancer drugs that are both potent and safe for cancer prevention and treatment. gallic acid(GA), a natural botanic phenolic compound, can mediate various therapeutic properties that are involved in anti-inflammation, anti-obesity, and anti-cancer activities. More recently, GA has been shown to exert anti-cancer activities via several biological pathways that include migration, metastasis, apoptosis, cell cycle arrest, angiogenesis, and oncogene expression. This review discusses two aspects, one is the anti-cancer potential of GA against different types of cancer and the underlying molecular mechanisms, the other is the bibliometric analysis of GA in cancer and tumor research. The results indicated that lung cancer, prostate cancer, stomach cancer, and colon adenocarcinoma may become a hot topic in further research. Overall, this review provides evidence that GA represents a promising novel, potent, and safe anti-cancer drug candidate for treating cancer.

关键词： gallic acid cancer tumor bibliometric application

Allelopathic effects of gallic acid from Aegiceras corniculatum on Cyclotella caspia

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Journal of Environmental Sciences 2013年第4期25卷 776-784页

作者： Yu Liu Fei Li Qixin Huang School of Environmental Science and Engineering Sun Yat-Sen University Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology

High abundance of algae and eutrophication were observed in mangrove wetlands and these were estimated to be associated with root exudates of some specific mangrove plants to a certain extent. Root exudates form allelopathic effects from mangroves. The main secondary metabolites of Aegiceras corniculatum had been detected to be organic phenolic acids. gallic acid had been isolated and identified from A. corniculatum. The half-maximal inhibitory concentration of gallic acid on alge Cyclotella caspia was tested as 15.46 mg/L. The effects on algal cell morphology were mainly shown as elongated cells, with no apparent cell inclusions, such as oil droplets, chloroplast. At a dose of 2 mg/L, gallic acid had a stimulative effect on the specific growth rate of algae on day 3. The contents of malondialdehyde, superoxide dismutase, soluble carbohydrates and chlorophyll a in algal cells showed an overall ＂low promotion and high suppression＂. Our results could provide preliminary and valuable reference on the complex influences of mangroves on microecology and microbial communities in the rhlzosphere system.

关键词： mangrove root exdutes microalgae allelopathy phenolic acids gallic acid

Influence of gallic acid on porcine neutrophils phosphodiesterase 4,IL-6,TNF-α and rat arthritis model

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Journal of Integrative Agriculture 2015年第4期14卷 758-764页

作者： JIANG Dai-xun ZHANG Mei-hua ZHANG Qian CHEN Yi-shan MA Wen-jing WU Wei-peng MU Xiang CHEN Wu Beijing Key Laboratory of Traditional Chinese Veterinary Medicine Beijing University of Agriculture

Our previous studies showed that the anti-inflammatory effects of Paeonia lactiflora roots extract may be mediated, at least in part, through its gallic acid content, and this effect may be regulated in part by an inhibition on c AMP-phosphodiesterase（PDE）. To explore the anti-inflammatory effect and mechanism, the influence of gallic acid on neutrophils PDE4 activity and expression, TNF-α and IL-6 content and rat arthritis model were further studied. PDE4 activity and gene express were calculated respectively by substrate c AMP change examined with HPLC and real-time RT-PCR. The concentration of IL-6 and TNF-α in supernatant were assayed by ELISA method. Model of rat arthritis was caused by complete Freund＇s adjuvant. Results showed that gallic acid had a dose-dependent restraint on PDE4 activity of neutrophils in vitro, promoted significantly PDE4 A expression（P〈0.01）, and had no influence on the expressions of PDE4 B and 4D. However, PDE4 C expression was not detected. gallic acid could promote IL-6 release（P〈0.05）, and inhibit TNF-α release of neutrophils（P〈0.05）. The experiment in vivo showed that gallic acid had obvious restraint on local inflammation of animal model（P〈0.05）. Therefore, the anti-inflammatory effect of gallic acid may be mediated in part through an inhibition on PDE4 activity and further an increase of IL-6 and a decrease of TNF-α of neutrophils, and this effect seemed to have no relationship with PDE4 expression.

关键词： gallic acid phosphodiesterase 4 inflammation IL-6 TNF-α neutrophils

Characterization of gallic acid Interaction with Human Serum Albumin by Spectral and Molecular Modeling Methods

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Chemical Research in Chinese Universities 2012年第2期28卷 287-290页

作者： LIU Zuo-jia LI Dan NIU Feng-lan School of Public Health Jilin UniversityChangchun 130021P.R.China

The binding of drugs with human serum albumin（HSA） is a crucial factor influencing the distribution and bioactivity of drugs in the *** understand the action mechanisms between gallic acid（GA,3,4,5-trihydroxybenzoic acid） and HSA,the binding of GA with HSA was investigated by a combined experimental and computational *** fluorescence properties of HSA and the binding parameters of GA collectively indicate that the binding is characterized by static quenching mechanism at one high affinity binding *** to the estimated molecular distance between the donor（HSA） and the acceptor（GA）,the binding is related to the fluorescence resonance energy *** indicated by the thermodynamic parameters,hydrophobic interaction plays a major role in the GA-HSA ***,the experimental results reveal that GA is bound in the large hydrophobic cavity of subdomain IIA in the site I of HSA,which is well approved by molecular docking.

关键词： gallic acid Human serum albumin Fluorescence quenching Molecular modeling

Properties and Anti-Ultraviolet Activity of gallic acid-Chitosan-Gelatin Mixed Gel

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Journal of Ocean University of China 2022年第1期21卷 204-212页

作者： WANG Wenjie XUE Changhu MAO Xiangzhao College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Qingdao 266200China

Hydrogel has high water content and structural similarity with natural extracellular *** it has been widely studied and applied in the field of *** order to further develop multifunctional hydrogels,we prepared mixed gels with antiultraviolet *** study found that the addition of polysaccharides and polyphenols was beneficial to the rheological,me-chanical properties,and biological activity of the ***(CS)could significantly improve the viscoelasticity,hardness,gel strength,thermal stability and crystallinity of ***,the addition of gallic acid(GA)could not only provide significant cross-linking effect,improve gel properties and microstructure,but also improve the UV resistance of the mixed gel.

关键词： gallic acid chitosan gelatin gel properties UV resistance

Flow-injection Chemiluminescence Sensor for the Determination of gallic acid by Immobilizing Luminol and Periodate on Anion-exchange Resin

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Chinese Journal of Chemistry 2002年第10期20卷 1049-1054页

作者：张四纯周国俊鞠熀先 Department of Chemistry Institute of Analytical Science State Key Laboratory of Coordination Chemistry Nanjing University Nanjing 210093 China

A novel chemiluminescence (CL) sensor for the determination of gallic acid combined with flow injection analysis was developed by electrostatically immobilizing luminol and periodate on anion-exchange resins respectively. gallic acid was sensed by its enhancing effect on the weak CL reaction between luminol and periodate, which were eluted from the ion exchange column. The possible reaction mechanism of the CL system was suggested and discussed. The response of the sensor to gallic acid concentration was linear over the range of 8.0×10 -9-1.0×10 -6 mol/L with a detection limit of 6.5×10 -9 mol/L (3σ). The relative standard deviation (RSD) for 7 repetitive determinations of gallic acid (1.0×10 -7 mol/L) was 1.8%. The sensor could be used for over 400 times determination with a good reproducibility.

关键词： chemiluminescence sensor gallic acid luminol periodate flow-injection analysis

Preparation of gallic acid-chitosan Copolymer and Its Antibacterial Activity against Staphylococcus Aureus and Escherichia Coli

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Journal of Wuhan University of Technology(Materials Science) 2021年第6期36卷 934-941页

作者： YAN Chunchao XIAO Feng QIU Tong ZHANG Xueqiong ZHAN Siwen LU Mengli YANG Mengjia ZHANG Juan College of Pharmacy Hubei University of Chinese MedicineWuhan 430065China Department of Pharmacy Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430060China School of Chemistry Chemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070China Maternal and Child Health Hospital of Hubei Wuhan 430070China

To synthesize three different grafting ratios of gallic acid(GA)-chitosan(CS)copolymer by a free radical mediated grafting method,which is further applied to the field of antibacterial materials,crosslinking structures of the compound GA-CS copolymer were characterized,fully indicating that gallic acid is resoundingly grafted onto *** grafting ratios of three copolymers GA-CS are 45.71%(Ⅰ),36.12%(Ⅱ),and 18.96%(Ⅲ)were determined by UV-Vis *** minimum inhibitory concentrations of three GA-CS copolymers are 30μg/mL against Escherichia coli and are ranged from 250 to 550μg/mL against Staphylococcus *** counting viable bacterial colonies,it can be found that antibacterial property is preferable by increasing the grafting ratio of GA-CS *** of investigation on aforementioned bacteria experiment indicate that the CFU/mL values of GA-CS(Ⅰ,Ⅱ,Ⅲ)are 2.04×10^(6),7.56×10^(6),1.48×10^(7) to Staphylococcus aureus,and 2.96×10^(6),1.01×10^(7),2.14×10^(7) to Escherichia coli after 12 h *** addition,the interaction process between GA-CS copolymer and bacteria can be observed through a transmission electron *** specific manifestation is that the bacterial cell membranes are ruptured after being treated with the copolymer,which causes the cell contents to flow out,and the cell morphology is shrunk and out ofshape.

关键词： gallic acid chitosan antibacterial activity antibacterial material

Determination of gallic acid by Flow Injection Analysis Based on LuminoI-AgNO3-Ag NPs Chemiluminescence System

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Chinese Journal of Chemistry 2012年第4期30卷 837-841页

作者：李世凤孙惠敏王东钱莉朱燕陶善军 College of Chemistry and Materials Science Anhui Key Laboratory of Functional Molecular Solids Anhui Key Laboratory of Molecule-based Materials Anhui Normal University Wuhu Anhui 241000 China

A novel flow injection procedure has been developed for the determination of gallic acid based on the en- hancement function for luminol-AgNO3-Ag NPs chemiluminescence （CL） system by gallic acid. The enhancement mechanism was proposed for the reinforcing effect of the gallic acid on the CL system. The UV-vis absorption spectrum and CL emission spectrum were applied to confirm the mechanism. The method is simple, rapid and sen- sitive with a detection limit of 5 × 10^-10 ***-l and a linear range of 8.0 × 10^-10- 1.0 × 10-7 ***-1. The relative standard deviation （RSD） is 1.3% for eleven measurements of 5 × 10^-8 g-mL-1 gallic acid. The method has been successfully applied to the determination of gallic acid in Chinese proprietary medicine--Jianmin Yanhou tablets and synthesized samples.

关键词： chemiluminescent enhancement luminol gallic acid Ag nanoparticles

Laser Flash Photolysis Studies on gallic acid

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Chinese Journal of Chemistry 2006年第10期24卷 1332-1335页

作者：朱红平赵红卫张兆霞王文锋姚思德 Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

The transient species of gallic acid （GA） have been studied by 266 run nanosecond laser flash photolysis in aqueous solution and acetonitfile. The intermediate with absorption at 320 nm was identified as excited triplet state （^3GA＊）, the decay rates of which were obtained in aqueous solution and acetonitrile respectively. Energy transfer from ^3GA＊ to β-carotene was observed and the energy transfer rate constant kent was determined to be 2.2×10^9 mol^-1·L·s^-1. GA underwent photoionization during photolysis and the quantum yield of photoionization was determined to be 0.12 at room temperature with KI as a reference.

关键词： gallic acid photolysis triplet state photoionization