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Versatile effects of galectin-1 protein-containing lipid bilayer coating for cardiovascular applications

Bioactive Materials 2024年第12期42卷 207-225页

作者： Md Lemon Hasan Ju Ro Lee Khandoker Asiqur Rahaman Dae Hyeok Yang Yoon Ki Joung Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Hwarangno 14-gil 5Seongbuk-guSeoul02792Republic of Korea Division of Bio-Medical Science&Technology University of Science and Technology(UST)113 GwahangnoYuseong-guDaejeon34113Republic of Korea Center for Systems Biology Massachusetts General Hospital Research InstituteBostonMA02114USA Department of Radiology Massachusetts General HospitalHarvard Medical SchoolBostonMA02114USA Institute of Cell and Tissue Engineering College of MedicineThe Catholic University of KoreaSeoul06591Republic of Korea KHU-KIST Department of Conversing Science and Technology Graduate SchoolKyung Hee UniversitySeoulRepublic of Korea

Modulating inflammatory cells in an implantation site leads to severe complications and still unsolved challenges for blood-contacting medical *** by the role of galectin-1(Gal-1)in selective functions on multiple cells and immunomodulatory processes,we prepared a biologically target-specific surface coated with the lipid bilayer containing Gal-1(Gal-1-SLB)and investigate the proof of the biological ***,lipoamido-dPEG-acid was deposited on a gold-coated substrate to form a self-assembled monolayer and then conjugated dioleoylphosphatidylethanolamine(DOPE)onto that to produce a lower leaflet of the supported lipid bilayer(SLB)before fusing membrane-derived vesicles extracted from B16-F10 *** Gal-1-SLB showed the expected anti-fouling activity by revealing the resistance to protein adsorption and bacterial *** vitro studies showed that the Gal-1-SLB can promote endothelial function and inhibit smooth muscle cell ***,Gal-1-SLB presents potential function for endothelial cell migration and angiogenic *** vitro macrophage culture studies showed that the Gal-1-SLB attenuated the LPS-induced inflammation and the production of macrophage-secreted inflammatory ***,the implanted Gal-1-SLB reduced the infiltration of immune cells at the tissue-implant interface and increased markers for M2 polarization and blood vessel formation in *** straightforward surface coating with Gal-1 can be a useful strategy for modulating the vascular and immune cells around a blood-contacting device.

关键词： galectin-1 protein Supported lipid bilayer Macrophage Cardiovascular devices Inflammation

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