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gadoxetic acid-enhanced magnetic resonance imaging in the assessment of hepatic sinusoidal obstruction syndrome in a mouse model

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World Journal of Hepatology 2024年第8期16卷 1167-1176页

作者： Yuan-Yuan Chen Li Yang Jun Li Sheng-Xiang Rao Ying Ding Meng-Su Zeng Department of Radiology Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND Neoadjuvant chemotherapy can cause hepatic sinusoidal obstruction syndrome(SOS)in patients with colorectal cancer liver metastases and increases posto-perative morbidity and *** To evaluate T1 mapping based on gadoxetic acid-enhanced magnetic resonance imaging(MRI)for diagnosis of hepatic SOS induced by *** Twenty-four mice were divided into control(n=10)and experimental(n=14)*** experimental groups were injected with monocrotaline 2 or 6 days before *** parameters were:T1 relaxation time before enhancement;T1 relaxation time 20 minutes after enhancement(T_(1post));a reduction in T1 relaxation time(△T_(1)%);and first enhancement slope percentage of the liver parenchyma(ESP).Albumin and bilirubin score was *** results served as a *** parenchyma samples from the control and experimental groups were analyzed by western blotting,and organic anion transporter polypeptide 1(OATP1)was *** T_(1post),△T_(1)%,and ESP of the liver parenchyma were significantly different between two groups(all P<0.001)and significantly correlated with the total histological score of hepatic SOS(r=-0.70,0.68 and 0.79;P<0.001).△T_(1)%and ESP were positively correlated with OATP1 levels(r=0.82,0.85;P<0.001),whereas T_(1post) had a negative correlation with OATP1 levels(r=-0.83;P<0.001).INTRODUCTION Hepatic sinusoidal obstruction syndrome(SOS)is also known as hepatic veno-occlusive disease of the liver[1].The main pathological feature of hepatic SOS is damage to liver terminal vessels,and the clinical symptoms of it include ascites and abdominal pain[2].It was first proposed in 1979 as an early complication of hematopoietic stem cell transplantation[3].The prevalence ranges from 5%to 60%,and hepatic SOS is a potentially severe complication and can even lead to death in severe cases[4].Recently,systemic neoadjuvant chemotherapy became widely regarded as one of the causes hepatic SOS in the patients with ad

关键词： T_(1)mapping gadoxetic acid Sinusoidal obstruction syndrome Organic anion transporter polypeptides Magnetic resonance imaging

Indeterminate liver lesions on gadoxetic acid-enhanced magnetic resonance imaging of the liver:Case-based radiologic-pathologic review

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World Journal of Hepatology 2021年第9期13卷 1079-1097页

作者： Jurate Noreikaite Dekan Albasha Vijay Chidambaram Ankur Arora Ashok Katti Department of Radiology Liverpool University Hospitals NHS Foundation TrustLiverpool L78XPUnited Kingdom

Different histopathological manifestations of focal liver lesions show varying common and uncommon imaging findings and some pathologies may show similar appearance despite of different *** is necessary to characterise focal liver lesions accurately as not only benign and malignant lesions are managed differently,but also certain benign lesions have differing *** lesions are increasingly being detected due to rapid growth of use of crosssectional imaging as well as improvement in image quality and new imaging *** enhanced magnetic resonance imaging(MRI)is considered the gold standard technique in characterising focal liver *** of gadoxetic acid has been shown to significantly increase diagnostic accuracy in the detection and characterization of liver *** imaging characteristics of common liver lesions,including their behaviour on gadoxetic acid enhanced MRI,have been described in literature over recent *** is important to be familiar with the typical aspects of these lesions as well as know the uncommon and overlapping imaging features to reach an accurate *** this article,we will review the well-described characteristic imaging findings of common and rare focal liver lesions and present several challenging cases encountered in the clinical setting,namely hepatocellular adenoma,focal nodular hyperplasia,hepatic angiomyolipoma,hepatocellular carcinoma,intrahepatic cholangiocarcinoma,neuroendocrine tumours as well as a pleomorphic liposarcoma of the liver.

关键词： Indeterminate liver lesions Magnetic resonance imaging gadoxetic acid Hepatobiliary phase Hepatocellular carcinoma

Diagnostic performance of abbreviated gadoxetic acid-enhanced magnetic resonance protocols with contrast-enhanced computed tomography for detection of colorectal liver metastases

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World Journal of Radiology 2022年第10期14卷 352-366页

作者： Kumi Ozaki Shota Ishida Shohei Higuchi Toyohiko Sakai Ayaki Kitano Kenji Takata Kazuyuki Kinoshita Yuki Matta Takashi Ohtani Hirohiko Kimura Toshifumi Gabata Department of Radiology University of FukuiFukui 9101193Japan Department of Radiological Technology Faculty of Medical ScienceKyoto College of Medical ScienceKyoto 6220041Japan Department of Radiology Kanazawa University Graduate School of Medical ScienceKanazawa 9208641Japan

BACKGROUND Although contrast-enhanced magnetic resonance imaging(MRI)using gadoxetic acid has been shown to have higher accuracy,sensitivity,and specificity for the detection and characterization of hepatic metastases compared with other modalities,the long examination time would limit the broad *** abbreviated enhanced MRI(Ab-MRI)protocols without dynamic phases have been proposed to achieve equivalent diagnostic performance for the detection of colorectal liver ***,an optimal protocol has not been established,and no studies have assessed the diagnostic performance of Ab-MRI combined with contrast-enhanced computed tomography(CE-CT),which is the preoperative imaging of colorectal cancer staging in clinical settings,to determine the best therapeutic *** To compare the diagnostic performance of two kinds of Ab-MRI protocol with the standard MRI protocol and a combination of the Ab-MRI protocol and CE-CT for the detection of colorectal liver *** Study participants comprised 87 patients(51 males,36 females;mean age,67.2±10.8 years)who had undergone gadoxetic acid-enhanced MRI and CE-CT during the initial work-up for colorectal cancer from 2010 to *** exam was independently reviewed by two readers in three reading sessions:(1)Only single-shot fast spin echo(FSE)T2-weighted or fat-suppressed-FSE-T2-weighted,diffusion-weighted,and hepatobiliary-phase images(Ab-MRI protocol 1 or 2);(2)all acquired MRI sequences(standard protocol);and(3)a combination of an Ab-MRI protocol(1 or 2)and *** performance was then statistically *** A total of 380 Lesions were analyzed,including 195 metastases(51.4%).Results from the two Ab-MRI protocols were *** sensitivity,specificity,and positive and negative predictive values from Ab-MRI were non-inferior to those from standard MRI(P>0.05),while those from the combination of Ab-MRI protocol and CE-CT tended to be higher than those from Ab-MRI alone,alt

关键词： Colorectal liver metastases gadoxetic acid Magnetic resonance imaging Hepatobiliary phase Contrast-enhanced computed tomography Diagnostic performance

早期肝细胞癌的影像研究:钆酸(gadoxetic acid)增强MRI的价值

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国际医学放射学杂志 2012年第1期 83-84页

作者： K.Sano T.Ichikawa U.Motosugi A.M.Muhi M.Matsuda 孟小茜 Departments of Radiology University of Yamanashi1110 ShimokatoChuo-shiYamanashi 409-3898Japan

目的描述早期肝细胞癌的钆酸增强MRI、动态增强CT、经动脉门静脉期CT及经肝动脉CT的影像学表现,比较各种方式对小肝癌(≤2.0cm)诊断能力。材料与方法学院伦理委员会认为该研究无需审批。64例病人的108个病灶

关键词：肝细胞癌早期肝癌 gadoxetic acid 肝动脉门静脉期 MRI

Assessment of the potential interactions between favipiravir and radiocontrast agents

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World Journal of Radiology 2024年第5期16卷 128-135页

作者： Sonay Aydin Ozlem Celik Aydin Mesut Furkan Yazar Huseyin Aydemir Mecit Kantarci Sureyya Barun Department of Radiology Erzincan Binali Yıldırım UniversityFaculty of MedicineErzincan 24100Türkiye Department of Pharmacology Gazi UniversityFaculty of MedicineErzincan 24100Türkiye Department of Radiology Bilecik Education and Reseach HospitalBilecik 11230Türkiye Department of Radiology Atatürk UniversityFaculty of MedicineErzurum 25030Türkiye

BACKGROUND In cases of coronavirus disease 2019(COVID-19),favipiravir is commonly included to the therapy *** interactions between favipiravir and other COVID-19 therapy drugs are frequently ***,no research on possible drug interactions between Favipiravir and radiocontrast agents,which have become almost crucial in diagnostic processes while not being part of the treatment,has been *** To determine potential medication interactions between Favipiravir and radiocontrast *** The study comprised patients who were taking Favipiravir for COVID-19 therapy and underwent a contrast-enhanced computed tomography(CT)or magnetic resonance imaging(MRI)test while taking the *** computerized patient files of the cases included in the study,as well as the pharmacovigilance forms in the designated hospital,were evaluated for this *** The study included the evaluation of data from 1046 *** study sample's mean age was 47.23±9.48 *** mean age of cases with drug interactions was statistically significant greater than that of cases with no drug interactions(P=0.003).When evaluated with logistic regression analysis,a 1-year raises in age increases the risk of developing drug interactions by 1.63 times(P=0.023).There was no statistically significant difference in the occurrence of medication interactions between the sexes(P=0.090).Possible medication interactions were discovered in 42 cases(4%).CONCLUSION The findings of this study revealed that the most notable findings as a result of the combined use of contrast agents and favipiravir were increased creatinine and transaminase values,as well as an increase in the frequency of nausea and *** majority of drug interactions discovered were modest enough that they were not reflected in the *** interactions become more common as people get older.

关键词： Favipiravir Iohexol gadoxetic acid Meglumine gadoterate Drug interactions

Preoperative Evaluation of Posthepatectomy Liver Failure Using MRI-Based Liver Function Indices in Child-Pugh Class A Patient

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Open Journal of Radiology 2016年第2期6卷 147-156页

作者： Shigeru Matsushima Yozo Sato Hidekazu Yamaura Mina Kato Yui Onoda Shinichi Murata Yasuhiro Shimizu Yasutomi Kinosada Hideyuki Nishiofuku Yoshitaka Inaba Department of Diagnostic and Interventional Radiology Aichi Cancer Center Hospital Nagoya Japan Department of Gastroenterological Surgery Aichi Cancer Center Hospital Nagoya Japan Departments of Biomedical Informatics Gifu University Graduate School of Medicine Gifu Japan Department of Radiology Nara Medical University Nara Japan

Purpose: To evaluate posthepatectomy liver failure (PHLF) using gadoxetic acid-enhanced magnetic resonance imaging (MRI) with a measure of relative liver enhancement (RLE) on hepatobiliary phase images, thereby facilitating safe liver resection. Methods: Twenty patients in Child-Pugh class A underwent tumor excision surgery and indocyanine green (ICG) clearance of future remnant liver (FRL) (ICG-Krem) values were >0.05. PHLF was evaluated using the grading system of the International Study Group of Liver Surgery (ISGLS). The RLE value was defined as the signal gain percentage between the precontrast and hepatocellular images. In the whole liver and FRL, theRLE value measured the tumor-free liver parenchyma in RLE images. We examined the correlation between indocyanine green clearance (ICG-K) and MRI-based liver function in the whole liver. Preoperative PHLF evaluation was predicted using remnant hepatocellular uptake index (rHUI), remnant RLE (rRLE), coefficient variation of Rrle [Cv(rRLE)], and ICG-Krem corrected by heterogeneous liver function(HLF-ICG-Krem). Results: HLF-ICG-Krem and rRLE values correlated with INRs after postoperative day five (r = -0.55 and 0.46, p = 0.01 and 0.04, respectively). Furthermore, HLF-ICG-Krem values ≤0.05 detected two patients with higher INRs after postoperative day five. On the other hand, neither rHUI nor Cv(rRLE) was correlated with INRs after postoperative day five (r = 0.28, and -0.03, respectively;p >0.05 for both). HLF-ICG-Krem was significantly lower with PHLF than without PHLF (p = 0.005). Conclusion: HLF-ICG-Krem is useful for evaluating PHLF more correctly.

关键词： Posthepatectomy Liver Failure Heterogeneous Liver Function gadoxetic acid Relative Liver Enhancement Indocyanine Green Clearance