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gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acidenhanced magnetic resonance imaging for evaluating fibrosis regression in chronic hepatitis C patients after direct-acting antiviral

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World Journal of Gastroenterology 2022年第20期28卷 2214-2226页

作者： Xiao-He Li Rui Huang Ming Yang Jian Wang Ying-Hui Gao Qian Jin Dan-Li Ma Lai Wei Hui-Ying Rao Peking University Hepatology Institute Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisPeking University People’s HospitalBeijing 100044China Hepatopancreatobiliary Center Beijing Tsinghua Changgung HospitalTsinghua UniversityBeijing 100044China

BACKGROUND Direct acting antiviral(DAA)therapy has enabled hepatitis C virus infection to become curable,while histological changes remain *** valid noninvasive methods can be confirmed for use in ***-ethoxybenzyl-diethylenetriamine penta-acetic acid(Gd-EOB-DTPA)is a liver-specific magnetic resonance imaging(MRI)contrast,related to liver function in the hepatobiliary phase(HBP).Whether Gd-EOB-DTPA-enhanced MRI can be used in the diagnosis and follow up of hepatic fibrosis in patients with chronic hepatitis C(CHC)has not been *** To investigate the diagnostic and follow-up values of Gd-EOB-DTPA-enhanced MRI for hepatic histology in patients with *** Patients with CHC were invited to undergo Gd-EOB-DTPA-enhanced MRI and liver biopsy before treatment,and those with paired qualified MRI and liver biopsy specimens were *** elastography(TE)and blood tests were also *** treated with DAAs who achieved 24-wk sustained virological response(SVR)underwent Gd-EOB-DTPA-enhanced MRI and liver biopsy *** signal intensity(SI)of the liver and muscle were measured in the unenhanced phase(UEP)(SI_(UEP-liver),SI_(UEP-muscle))and HBP(SI_(HBP-liver),SI_(HBP-muscle))via *** contrast enhancement index(CEI)was calculated as[(SI_(HBP-liver)/SI_(HBP-muscle))]/[(SI_(UEP-liver)/SI_(UEP-muscle))].Liver stiffness measurement(LSM)was confirmed with *** markers,aspartate aminotransferase-to-platelet ratio index(APRI)and Fibrosis-4(FIB-4),were also calculated according to blood *** grade of inflammation and stage of fibrosis were evaluated with the modified histology activity index(mHAI)and Ishak fibrosis score,*** regression was defined as a≥1-point decrease in the Ishak fibrosis *** correlation between the CEI and liver pathology was *** diagnostic and follow-up values of the CEI,LSM,and serologic markers were *** Thirty-nine patients with CHC wer

关键词： gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced magnetic resonance imaging Contrast enhancement index Hepatitis C virus Direct acting antiviral Sustained virological response Fibrosis regression

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