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Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

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SIGNAL TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 1-66页

作者： Lu, Peilin Ruan, Dongxue Huang, Meiqi Tian, Mi Zhu, Kangshun Gan, Ziqi Xiao, Zecong Sun Yat Sen Univ Affiliated Hosp 3 Nanomed Res Ctr Guangzhou 510630 Peoples R China Guangzhou Med Univ Affiliated Hosp 2 Dept Minimally Invas Intervent Radiol Guangzhou 510260 Peoples R China Guangzhou Med Univ Affiliated Hosp 2 Lab Intervent Radiol Guangzhou 510260 Peoples R China Guangzhou Med Univ Affiliated Hosp 1 Guangzhou Inst Resp Hlth State Key Lab Resp DisNatl Clin Res Ctr Resp Dis Guangzhou 510120 Peoples R China Chengdu Second Peoples Hosp Dept Stomatol Chengdu 610021 Peoples R China Sun Yat Sen Univ Hosp Stomatol Guanghua Sch Stomatol Guangdong Prov Key Lab Stomatol Guangzhou 510055 Peoples R China

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements and the potential of hydrogels in therapeutic applications, focusing primarily on two areas: emerging cell-based therapies and promising non-cell therapeutic modalities. Within the context of cell therapy, we discuss the capacity of hydrogels to overcome the existing translational challenges faced by mainstream cell therapy paradigms, provide a detailed discussion on the advantages and principal design considerations of hydrogels for boosting the efficacy of cell therapy, as well as list specific examples of their applications in different disease scenarios. We then explore the potential of hydrogels in drug delivery, physical intervention therapies, and other non-cell therapeutic areas (e.g., bioadhesives, artificial tissues, and biosensors), emphasizing their utility beyond mere delivery vehicles. Additionally, we complement our discussion on the latest progress and challenges in the clinical application of hydrogels and outline future research directions, particularly in terms of integration with advanced biomanufacturing technologies. This review aims to present a comprehensive view and critical insights into the design and selection of hydrogels for both cell therapy and non-cell therapies, tailored to meet the therapeutic requirements of diverse diseases and situations.

关键词： MESENCHYMAL STEM-CELLS GELATIN-METHACRYLOYL HYDROGELS CROSS-LINKABLE HYDROGELS DRUG-DELIVERY SYSTEM T-CELL growth-factor MECHANICAL-PROPERTIES PHOTODYNAMIC THERAPY INJECTABLE HYDROGEL PLASMID DNA

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