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Relationship between Platelet Activation Related Factors and Polymorphism of Related Genes in Patients with Coronary Heart Disease of blood-stasis Syndrome

引用

Chinese Journal of Integrative Medicine 2008年第4期14卷 267-273页

作者：薛梅陈可冀殷惠军 Xiyuan Hospital China Academy of Chinese Medical Sciences

Objective： To comparatively study the expressive conditions of platelet activation related factors （gpⅠb, gpⅱb-ⅲa and GMP-140） in healthy subjects and patients with coronary heart disease （CHD） of blood-stasis （bS） or non-blood-stasis （non-bS） syndrome, and to analyze the relationship between the activities of various glycoproteins and the polymorphism of genes. Methods： With case control design adopted, patients with the CHD （40 of bS, 37 of non-bS） and 39 healthy subjects for control, all fitting to the inclusion criteria, were selected in this study. The number of affected coronary branches was recorded by the contrast examination. The mean fluorescence intensity （MFI） of gpⅰb, gpⅱb-ⅲa, and GMP-140 （CD42b, CD61, CD62p） in patients and healthy persons was measured with flow cytometry, the polymorphism of HPA-3 gene was detected by Taqman probe technique and that of HPA-2 gene was determined by gene sequencing. Results： MFI of CD61 and CD62p was higher in the CHD patients than in the healthy control, which was also higher in patients of bS syndrome than in patients of non-bS syndrome （P〈0.05）; MFI of CD42b was lower in the CHD patients than in the healthy control （P〈0.05）, but showing insignificant difference between bS and non-bS syndrome （P〉0.05）; at the same time, no significant difference of all the above-mentioned three MFI could be found in patients with various numbers of affected coronary branches, neither in patients with different genotypes at gpⅡb HPA-3 and gpⅰb HPA-2 polymorphism loci （P〉0.05）. Conclusion：（1） The activities of gp Ⅱ b-Ⅲa and GMP-140 were obviously increased in the genesis and developing process of CHD and CHD of bS syndrome, and so they could be taken as one of the objective indexes for microscopic diagnosis of bS syndrome. （2） The level of gpⅰb was lower in CHD patients than in healthy persons, but it was not a sensitive indicator for bS syndrome of CHD. （3） Levels of gp Ⅱb-Ⅲa, gpⅰb and GMP-140 were not related with the number of affected coronary branches in CHD patients. （4） The c

关键词： coronary heart disease blood-stasis syndrome gpⅱb-ⅲa, gpⅰb GMP-140 platelet activation gene polymorphism

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