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A Reliable Neighbor-Based Method for Identifying Essential Proteins by Integrating Gene Expressions, Orthology,and Subcellular Localization Information

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Tsinghua Science and Technology 2016年第6期21卷 668-677页

作者： Min Li Zhibei Niu Xiaopei Chen Ping Zhong Fangxiang Wu Yi Pan the School of Information Science and Engineering Central South University the Department of Mechanical Engineering and Division of Biomedical Engineering University of Saskatchewan the Department of Computer Science Georgia State University

Essential proteins are those necessary for the survival or reproduction of species and discovering such essential proteins is fundamental for understanding the minimal requirements for cellular life, which is also meaningful to the disease study and drug design. With the development of high-throughput techniques, a large number of Protein-Protein Interactions（PPIs） can be used to identify essential proteins at the network level. Up to now, though a series of network-based computational methods have been proposed, it is still a challenge to improve the prediction precision as the high false positives in PPI networks. In this paper, we propose a new method gos to identify essential proteins by integrating the Gene expressions, Orthology, and Subcellular localization *** gene expressions and subcellular localization information are used to determine whether a neighbor in the PPI network is reliable. Only reliable neighbors are considered when we analyze the topological characteristics of a protein in a PPI network. We also analyze the orthologous attributes of each protein to reflect its conservative features, and use a random walk model to integrate a protein＇s topological characteristics and its orthology. The experimental results on the yeast PPI network show that the proposed method gos outperforms the ten existing methods DC, BC, CC, SC, EC, IC, NC, Pe C, ION, and CSC.

关键词： essential protein reliable neighbors gos orthology subcellular localization information

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含低聚半乳糖的生物活性果粒发酵乳及其保藏性研究

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中国乳品工业 2013年第5期41卷 56-60页

作者：李德龙米晓冲钱利芳安胜明张波吴金鸿高艳玲上海交通大学农业与生物学院上海200240

通过紫外分光光度法对s种水果包括桃、青李子、黑布林、苹果和杏进行乳糖酶的检测筛选和果粒巴氏消毒条件研究。结果表明：黑布林和杏富舍乳糖酶，含量分别是0．034u／mL和0．018U／mL。确定了富含G0s的果粒发酵乳的最佳制备条件为：将... 详细信息

通过紫外分光光度法对s种水果包括桃、青李子、黑布林、苹果和杏进行乳糖酶的检测筛选和果粒巴氏消毒条件研究。结果表明：黑布林和杏富舍乳糖酶，含量分别是0．034u／mL和0．018U／mL。确定了富含G0s的果粒发酵乳的最佳制备条件为：将黑布林和杏切成1cm。大小的果粒，65℃水浴30min巴氏消毒，按质量分数为8％添加到灭菌的复原脱脂乳中,Lactobacillus delbrueckii *** LB340和Bifidobacterium bifidum BB03质量比为1：1，总接种量3％o（质量分数），在42℃，常规发酵10h，产物中gos质量分数达1．10％～1．40％。该酸乳在4℃保藏14d。产品黏度为（0．74±0．25）Pa·S，酸度为（181．7±12．1）。T，pHi为4．15±0．06，Lactobacillus delbmrueckii *** LB340和Bifidobacterium bifidum BB03活菌数为1．50×10^（11）～2．00×10^（15）mL^（-1）。因此在2周的储藏期内，酸奶的各项理化指标均符合发酵乳的国家标准。

关键词： gos 发酵乳保藏

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Online Scheduling on Two Parallel Identical Machines Under a Grade of Service Provision

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Journal of the Operations Research Society of China 2022年第4期10卷 689-702页

作者： Shuang Cai Ke Liu Data Department Beijing Kingsoft Cloud Network Technology Co.Ltd.Beijing100086China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100190China

In this paper,we investigate online scheduling problems on two parallel identical machines under a grade of service provision with makespan as the objective *** jobs arrive over time and each job can be scheduled only when it has already been *** consider three different versions:(i)the two machines cannot be idle at the same time until all arrived jobs have been processed;(ii)further to the first problem,jobs are processed on a first-come,first-serviced basis;(iii)each job must be assigned to one of the two machines as soon as it *** for three online scheduling problems,optimal online algorithms are proposed with competitive ratio(√5+1)/2,(√5+1)/2 and 5/3.

关键词： Online scheduling Parallel machines A grade of service provision gos

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A real-time tunable arbitrary power ratios graphene based power divider

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Science China(Information Sciences) 2018年第8期61卷 104-106页

作者： Haowen SHU Yuansheng TAO Ming JIN Xingjun WANG Zhiping ZHOU State Key Laboratory of Advanced Optical Communications System and Networks School of Electronics Engineering and Computer Science Peking University

Dear editor,Recently,photonics integrated circuits have attracted extensive consideration for its realization of large-scale integration of various devices and functionalities on a single chip[1].As a fundamental buil... 详细信息

关键词： Figure A real-time tunable arbitrary power ratios graphene based power divider length gos

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Delay Testing Viability of Gate Oxide Short Defects

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Journal of Computer Science & Technology 2005年第2期20卷 195-200页

作者： J.M.Gallière M.Renovell F.Azais Y.Bertrand Laboratoired＇InformatiqueRobotiqueMicroèlectroniquedeMontpellierLIRMM-UMII UniversitddeMontpellierH：SciencesetTechniquesduLanguedocUMRC5506CNRS-161rueAda34392MontpellierCedex5France

Gate Oxide Short (gos) defects are becoming predominant as technology is scaling down. Boolean and IDDQ testing of this defect has been widely studied but there is no paper dedicated to delay testing of this defect. So, this paper studies the delay behavior of Gate Oxide Short faults due to pinhole in the gate oxide. The objective of this paper is to give a detailed analysis of the behavior of the gos defect taking into account the random parameter of the defect such as the gos resistance and the gos location. Because an accurate analysis is desired, the bi-dimensional array will be *** a complete analysis is desired, we derive the dynamic characteristic of the gos as a function of the gos resistance and location. It is demonstrated that i) gos has a significant impact on gate delay, ii) gos located close to the source of the transistor and with small resistance has very high impact.

关键词： VLSI 延迟测试 gos 集成电路

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Evaluating the prognosis and degree of brain injury by combined S-100 protein and neuron specific enolase determination

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Neural Regeneration Research 2006年第7期1卷 649-652页

作者： Xihua Wang Xinding Zhang Department of Neurosurgery Second affiliated HospitalLanzhou UniversityLanzhou 730030Gansu ProvinceChina Department of NeurosurgerySecond affiliated HospitalLanzhou UniversityLanzhou 730030Gansu ProvinceChina

BACKGROUND: S-100 and neuron specific enolase (NSE) possess the characteristics of specific distribution in brain and relative stable content. Some studies suggest that combined detection of the both is of very importance for evaluating the degree of brain injury. OBJECTIVE: To observe the changes of S-100 protein and NSE levels at different time points after acute brain injury, and evaluate the values of combined detection of the both for different injury degrees, pathological changes and prognosis. DESIGN: Case-control observation. SETTING: Department of Neurosurgery, Second Affiliated Hospital, Lanzhou University. PARTICIPANTS: Thirty-four inpatients with brain injury, 19 males and 15 females, aged 15 to 73 years, who received treatment between September 2005 and May 2006 in the Department of Neurosurgery, Second Affiliated Hospital, Lanzhou University, were recruited. The patients were admitted to hospital at 24 hours after brain injury. After admission, skull CT confirmed that they suffered from brain injury. Following Glasgow coma score (GCS) on admission, the patients were assigned into 3 groups: severe group (GCS 3 to 8 points, n =15), moderate group (GCS 9 to 12 points, n =8) and mild group (GCS 13 to 15 points, n =11). Following Glasgow outcome scale (gos) at 3 months after brain injury, the patients were assigned into good outcome group (gos 4 to 5 points, good recovery and moderate disability included, n =19) and poor outcome group (gos 1 to 3 points, severe disability, vegetative state and death, n =15). Ten subjects who received health examination concurrently were chosen as normal control group , including 6 males and 4 females , aged (45.4±14.3)汤(c)years. In our laboratory, the normal level of NSE was ≤15.2 ng/L, and that of S100 was ≤0.105μg/L. METHODS: ①Blood samples of control group were collected when the subjects received health examination. Blood samples of patients with brain injury were collected at 24 hours, 3, 7 and 14 days after injury. Ac

关键词： NSE gos GCS

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半乳糖寡糖对小白鼠食物转化率及钙吸收的影响

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南昌大学学报（工科版） 2004年第4期26卷 46-48页

作者：王筱兰欧阳二明欧阳涟南昌大学生命科学学院江西南昌330047

固定化β-半乳糖苷酶合成的产物,经柱层析分离纯化得到的纯半乳糖寡糖溶液用于喂食小鼠动物试验.把15只体重20±1.5g的雄性小鼠分成三组饲养.gos组:在喂食普通鼠饲料基础上,每天灌喂0.15～0.20mL10%的半乳糖寡糖溶液;乳糖组:在喂食普通... 详细信息

固定化β-半乳糖苷酶合成的产物,经柱层析分离纯化得到的纯半乳糖寡糖溶液用于喂食小鼠动物试验.把15只体重20±1.5g的雄性小鼠分成三组饲养.gos组:在喂食普通鼠饲料基础上,每天灌喂0.15～0.20mL10%的半乳糖寡糖溶液;乳糖组:在喂食普通鼠饲料基础上,每天灌喂0.15～0.20mL10%的乳糖溶液;对照组:每天只喂食普通鼠饲料和去离子水.收集小鼠的粪便用原子吸收测定钙含量并计算钙吸收率.第16d解剖小鼠,取血清测定血清钙,取小鼠肱骨测定其钙含量.gos组小鼠的食物转化率、血清钙和钙吸收率、以及小鼠的肱骨的钙含量和钙比重高于对照组.说明半乳糖寡糖能提高小鼠的食物转化率,促进小鼠钙的吸收.

关键词：小鼠半乳糖食物 gos 对照组钙吸收肱骨喂食寡糖饲料

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Clinical significance of large decompressive craniectomy to control intractable increased intracranial pressure in patients with traumatic brain injury

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外科研究与新技术 2011年第3期 199-200页

作者：张赛 Dept Neurosurg SurgCenter Neurosurg Pingjin HospMed Col Chin Peopl Armed Police Forces

Objective To investigate the role of decompressive craniectomy (DC) to decrease intractable intracranial hypertension(ICH) due to diffuse brain swelling and / or cerebral edema after severe traumatic brain injury and the time window of DC to affect on prognosis. Methods The clinical record of 132 patients who underwent DC for posttraumatic intractable ICH in our hospital from July 2003 to

关键词： gos Clinical significance of large decompressive craniectomy to control intractable increased intracranial pressure in patients with traumatic brain injury CPP

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亚低温对重型脑损伤患者继发性脑损伤的作用评价

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中华急诊医学杂志 2017年第12期26卷 1375-1378页

作者：熊伟川曹小宏李新明万建国南昌大学第三附属医院急危重症医学部南昌330008 南昌大学第三附属医院影像科南昌330008 南昌大学第三附属医院神经内科南昌330008

目的评估亚低温联合高压氧（hyperbaricoxygen，HBO）对重型颅脑损伤患者继发性脑损害的影响。方法本次临床试验研究为前瞻性研究，将伤后8h内入院的重型颅脑损伤患者42例，采用随机数字表法分为亚低温联合HBO的治疗组和常规HBO治疗的... 详细信息

目的评估亚低温联合高压氧（hyperbaricoxygen，HBO）对重型颅脑损伤患者继发性脑损害的影响。方法本次临床试验研究为前瞻性研究，将伤后8h内入院的重型颅脑损伤患者42例，采用随机数字表法分为亚低温联合HBO的治疗组和常规HBO治疗的对照组各2l例。分别于伤后第1天、15天、30天复查头颅cT，计算脑出血量及脑水肿体积；同时进行GCS（GlasgowComaScale）评分；统计两组患者出现脑梗死的例数；伤后半年，对两组患者进行gos（GlasgowOutcomeScore）预后评分。采用SPSS13．0统计软件，两组样本率的比较采用连续性校正的X。检验，用独立样本t检验进行组间两两比较，以P〈0．05为差异具有统计学意义。结果（1）治疗组伤后15d和30d的脑出血量和水肿体积明显小于对照组[（21．71±4．3）vs．（26．33±5．23）；（14．33±1．93）vs．（16．86±2．86），P〈0．05]；（2）伤后15d和30d治疗组GCS评分高于对照组[（4．62±0．49）vs．（4．29±0．56）；（9．76±1．37）vs．（8．57±0．92），P〈0．05]；（3）治疗组出现外伤性脑梗死2例数，而对照组9例（χ2=4．434，P=0．035）；伤后6个月，治疗组gos评分高于对照组[（4．29±0．84）vs．（3．38±0．74），P=0．001]。结论亚低温联合高压氧治疗能够减轻重型颅脑损伤的继发性脑损伤和改善患者预后，值得临床上进一步探讨，亚低温的作用机制有待于进一步研究。

关键词：亚低温高压氧重型颅脑损伤继发性脑损伤体温管理脑梗死 GCS gos

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磁共振波谱成像在中脑损伤预后判断中的价值

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中华神经外科杂志 2010年第6期26卷 510-512页

作者：叶伟于明琨上海长征医院神经外科 200003

目的研究中脑损伤患者急性期（＜7 d）中脑磁共振波谱（MRS）的变化,为中脑损伤提供影像学诊断依据及功能评价的参考.方法收集本院自2007年11月至2008年9月临床确诊为中脑损伤的病例资料（22例）,同时收集健康成人资料（10例）建立对... 详细信息

目的研究中脑损伤患者急性期（＜7 d）中脑磁共振波谱（MRS）的变化,为中脑损伤提供影像学诊断依据及功能评价的参考.方法收集本院自2007年11月至2008年9月临床确诊为中脑损伤的病例资料（22例）,同时收集健康成人资料（10例）建立对照.将中脑损伤的MRS结果进行分析和归类总结,评价脑干功能.在患者出院后,对相关病例随访6个月,根据gos、DRS与Barthal评分评价患者的预后与生存质量,并分析MRS与预后之间的关系,更好地判断病情及预后.结果中脑损伤后中脑区的NAA/Cr和NAA/Cho比值显著降低;NAA/Cr和NAA/Cho比值降低越明显,预后越差;中脑损伤区域不同,其中脑区NAA/Cr和NAA/Cho比值和预后也不同.结论不同的中脑损伤区域,其MRS检查结果与预后是不同的.依据颅脑损伤后中脑MRS中NAA/Cr和NAA/Cho比值的变化,可以为中脑损伤的患者提供相对可靠的伤情判断与预后评价指标.

关键词：脑损伤磁共振波谱成像预后 Barthal评分 gos

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