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China Rare Earth Information 2015年第3期21卷 3-6页

Source:MIT Technology ntroduction Not all breakthroughs are created *** arrive more or less as usable things;others mainly set the stage for innovations that emerge later,and we have to estimate when that will *** we... 详细信息

关键词： usable created things Magic arrive emerge coming imagery educational genomics

Genomic and genetic basisof seed nutritional content in Eragrostistef

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Genomic and genetic basisof seed nutritional content in Erag...

TOTAL CONTENTS Tsinghua Science and Technology,Vol.13,2008

2015中国遗传学会大会

作者： Xuewen Wang Micai Zhon Meng Li Srini Chaluvadi Katrien Devos Greg Ziegler Ivan Baxter Jeff Bennetzen Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of Sciences Department of Genetics University of Georgia Department of Plant Biologyand Institute of Plant Breeding Genetics and Genomics(Department of Crop and Soil Sciences)University of Georgia

Tef(Eragrostistef),a tetraploid grass,is the mainstay of Ethiopian agriculture,with more acres planted than in any other *** has one of the bestmineral contentsamong cereals,with similarly high levels only found in another Chloridoid cereal,fiuger *** has high resilience to both drought and waterlogged soils,but its yield is low due to tiny seed size and severe susceptibility to *** have used mutational and other genetic approaches to investigate and help solve these *** is very high in protein and iron,and has more calcium than mother’s ***,we have generated the1st high density genetic map using SNPs in our newly developed genotype-by-sequencing *** new map has2002 SNP markers fora 145-RIL population,and generated 20 major linkage groups sorted into A andB genomes of this *** anchored more than 73%sequences of tef genomic contigs and scaffolds in the SNP genetic map,and more sequences after combining a SSR map,meaning an accomplishment of tef *** have used this map to identify QTL associated mineral content.A total of19 QTL were identified from the analysis of twenty minerals in ***-seqanalysis of developing seeds revealed QTL genes involved in nutritional *** combined with two full genome sequence analyses that have recently been completed,these analyses should undercover candidate genes associated with these traits,thus suggesting routes towards further nutritional improvement of tef and other cereals.

关键词： GBS ionomics mineral content QTL tef genomics

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Tsinghua Science and Technology 2008年第6期13卷 858-862页

Understand SLE heterogeneity in the era of omics,big data,and artificial intelligence

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Rheumatology & Autoimmunity 2021年第1期1卷 40-51页

作者： Prianka Puri Simon H.Jiang Yang Yang Fabienne Mackay Di Yu Kidney Health Service Royal Brisbane and Women's HospitalBrisbaneQueenslandAustralia The University of Queensland Diamantina Institute Faculty of MedicineThe University of QueenslandWoolloongabbaQueenslandAustralia Department of Immunology and Infectious Disease John Curtin School of Medical ResearchActonAustralian Capital TerritoryAustralia Centre for Personalised Immunology NHMRC Centre for Research ExcellenceActonAustralian Capital TerritoryAustralia Department of Renal Medicine The Canberra HospitalGarranAustralian Capital TerritoryAustralia QIMR Berghofer Medical Research Institute in Brisbane QLD HerstonQueenslandAustralia

Systemic lupus erythematosus(SLE)is a systemic autoimmune disease characterized by extraordinary heterogeneity,due to the complex pathogenesis and diverse *** of patients for therapy and prognosis represents a major challenge to manage *** biomarkers for disease diagnosis and activity assessment provide very limited insight into immunological pathogenesis and therapeutic response *** advancement of“omics”technologies including genomics,transcriptomics,proteomics,and metabolomics has constituted an unprecedented opportunity to characterize the immunopathological landscape in individual patients with ***,genomic studies reveal a subset of SLE patients carrying one or more functional single nucleotide polymorphisms(SNPs)underlying immune dysregulation while transcriptomic studies have revealed subgroups in SLE patients showing distinct signatures for Type I interferon(TI-IFN)pathway activation or aberrant differentiation of B cells into plasma *** review will summarize results from the latest studies using omics technology to understand SLE *** addition,we propose that the application of artificial intelligence,such as by machine learning-based nonlinear dimensionality reduction method uniform manifold approximation and projection(UMAP)can further strengthen the analysis of omics big *** combination of new technology and novel analysis pipeline can lead to breakthroughs in stratifying SLE patients for a better monitoring of disease activity and more precise design of treatment regime,not only for conventional immunosuppression but also novel immunotherapies targeting B-cell activating factor(BAFF),TI-IFN,and interleukin 2(IL-2).

关键词： classification genomics metabolomics proteomics transcriptomics

Instructions for Authors

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Journal of Genetics and genomics 2007年第11期34卷 1048-1051页

Journal of Genetics and genomics (JGG,for-merly known as Acta Genetica Sinica) is one of China’s leading journals in life *** is spon-sored by the Genetics Society of China and the Insti-tute of Genetics and Developm... 详细信息

关键词： Genetics genomics figures submitted submission acceptance letters copyright editorial http

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药物表型组学与传统中医药(英文)

中国药理学与毒理学杂志 2015年第S1期29卷 1-2页

作者：段大跃 Laboratory of Cardiac and Vascular Phenomics Center for Molecular MedicineDepartment of PharmacologyUniversity of Nevada School of MedicineReno Nevada USA 89557

In the post-genome era,different omics methods have been used to establish the relationship between clinical phenotypes and molecular *** combination of genomics,proteomics,and metabolomics has unraveled the etiology and pathophysiology of various diseases in a big-data fashion and the recent Genome-Wide Association Studies(GWAS)have provided a powerful systematic method to investigate the impact of common genomic variations on human cardiovascular pathophysiology and ***,these studies also revealed unmatched relationships between the genomic variability and the much narrower definition of various clinical phenotypes of cardiovascular diseases in individual *** the majority of GWAS a single targeted disease or a pre-defined and limited phenotype(trait)was studied and the accrual of such a large number of single gene variant-phenotype associations has led to the serendipitous identification of single loci associated with multiple diseases,or one gene being responsible or affecting more than one phenotypic characteristic(pleiotropy).Clearly,Western medicine is now facing the same challenges as traditional Chinese medicine(TCM)and newer approaches are needed for the redefinition of diseases using the underlying molecular causes and other factors in addition to traditional signs and *** are the same old questions for TCM for many years.A new method named″Phenome-Wide Association Study(PheWAS)″as an alternative approach that complements GWAS and utilizes phenomics and big-data technologies to analyze all genetic/proteomic variants and all available phenotypic information in the estimation of association between genome-phenome and detection of *** is a recently developed new transdiscipline that provides a suite of new technologies and platforms for the transition from focused phenotype-genotype study to a systematic phenome-genome approach,which can be used to redefine the clinical phenotypes of ***

关键词： genomics pharmacogenetics pharnacogenomics pharmac

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对话人类基因组计划领衔专家*** Venter

科学通报 2017年第8期62卷 743-744页

作者：王元火贾旭明张冬梅

*** Venter,美国科学院院士,生物学家及企业家.1984年,Venter进入了美国国家卫生研究院（National Institutes of Health,NIH）.1991年,Venter和他的团队开发了表达序列标签（ESTs）,这是一种新技术,可以迅速地发现基因.1992年他创立了... 详细信息

*** Venter,美国科学院院士,生物学家及企业家.1984年,Venter进入了美国国家卫生研究院（National Institutes of Health,NIH）.1991年,Venter和他的团队开发了表达序列标签（ESTs）,这是一种新技术,可以迅速地发现基因.1992年他创立了一个非营利研究机构——基因组研究所（The Institute for Genomic Research,TIGR）.1998年,成立了Celera genomics公司,进行人类基因组测序.2001年,

关键词：人类基因组计划基因组测序 J.Craig Venter genomics 团队开发研究机构表达序列标签 ESTs 美国科学院临床试验数据

Integrative omics analysis identifies macrophage migration inhibitory factor signaling pathways underlying human hepatic fibrogenesis and fibrosis

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Journal of Bio-X Research 2019年第1期2卷 16-24页

作者： Zhipeng Liu Naga Chalasani Jingmei Lin Samer Gawrieh Yuan He Yan J.Tseng Wanqing Liu Department of Medicinal Chemistry and Molecular Pharmacology College of PharmacyPurdue UniversityWest Lafayette Division of Gastroenterology and Hepatology Indiana University School of MedicineIndianapolisIN Department of Pathology Indiana University School of MedicineIndianapolisIN Department of Biochemistry Microbiology and ImmunologySchool of MedicineWayne State UniversityDetroitMIUSA Center for Molecular Medicine and Genetics Wayne State UniversityDetroitMIUSA Department of Pharmaceutical Sciences Eugene Applebaum College of Pharmacy and Health SciencesWayne State UniversityDetroitMIUSA Department of Pharmacology School of MedicineSchool of MedicineWayne State UniversityDetroitMIUSA Cancer Biology Program Karmanos Cancer InstituteSchool of MedicineWayne State UniversityDetroitMIUSA

The genetic basis underlying liver fibrosis remains largely *** conducted a study to identify genetic alleles and underlying pathways associated with hepatic fibrogenesis and fibrosis at the genome-wide level in 121 human *** accepting a liberal significance level of P<1e-4,we identified 73 and 71 candidate loci respectively affecting the variability in alpha-smooth muscle actin(a-SMA)levels(fibrogenesis)and total collagen content(fibrosis).The top genetic loci associated with the two markers were BAZA1 and NOL10 for a-SMA expression and FAM46A for total collagen content(P<1e-6).We further investigated the relationship between the candidate loci and the nearby gene transcription levels(cis-expression quantitative trait loci)in the same liver *** found that 44 candidate loci for a-SMA expression and 44 for total collagen content were also associated with the transcription of the nearby genes(P<0.05).Pathway analyses of these genes indicated that macrophage migration inhibitory factor(MIF)related pathway is significantly associated with fibrogenesis and fibrosis,though different genes were enriched for each *** association between the single nucleotide polymorphisms,MIF and a-SMA showed that decreased MIF expression is correlated with increased a-SMA expression,suggesting that variations in MIF locus might affect the susceptibility of fibrogenesis through controlling MIF gene *** summary,our study identified candidate alleles and pathways underlying both fibrogenesis and fibrosis in human *** bioinformatics analyses suggested MIF pathway as a strong candidate involved in liver fibrosis,thus further investigation for the role of the MIF pathway in liver fibrosis is *** study was reviewed and approved by the Institutional Review Board(IRB)of Wayne State University(approval No.201842)on May 17,2018.

关键词： hepatic fibrosis genomics macrophage migration inhibitory factor alpha-smooth muscle actin pathway enrichment analysis genetic susceptibility

Recent advances in the molecular genetics of resin biosynthesis and genetic engineering strategies to improve defenses in conifers

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Journal of Forestry Research 2003年第2期14卷 171-179页

作者：唐巍 O-23 E.S.King Village2900 Ligon St.North Carolina State University

Since the first terpenoid synthase cDNA was obtained by the reverse genetic approach from grand fir, great progress in the molecular genetics of terpenoid formation has been made with angiosperms and genes encoding a monoterpene synthase, a sesquiterpene synthase, and a diterpene synthase. Tree killing bark beetles and their vectored fungal pathogens are the most destructive agents of conifer forests worldwide. Conifers defend against attack by the constitutive and inducible production of oleoresin that accumulates at the wound site to kill invaders and both flush and seal the injury. Although toxic to the bark beetle and fungal pathogen, oleoresin also plays a central role in the chemical ecology of these boring insects. Recent advances in the molecular genetics of terpenoid biosynthesis provide evidence for the evolutionary origins of oleoresin and permit consideration of genetic engineering strategies to improve conifer defenses as a component of modern forest biotechnology. This review described enzymes of resin biosynthesis, structural feathers of genes genomic intron and exon organization, pathway organization and evolution, resin production and accumulation, interactions between conifer and bark beetle, and engineering strategies to improve conifer defenses.

关键词： Genetic engineering strategies Resin biosynthesis Bark beetles genomics Molecular genetics