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gene engineering eb virus membrane antigen in detection of ma-iga antibody(COMPARISON WITH VCA-iga AND EA-iga ANTIBODIES)

引用

Chinese Journal of Cancer Research 1991年第2期3卷 33-36页

作者：刘孟忠李振权皮国华 Tumor Hospital Cancer Centre Sun Yat-sen University of Medical Sciences Guangzhou Institute of Virology Chinese Academy of Preventive Medicine Beijingith gene engineering EB virus membrane antigen as the diagnostic antigen indirect immunofluo-rescence (IF) assay was used to detect IgA antibody against EB virus membrane antigen (MA-IgA) in sera from 202 nasopharyngeal carcinoma (NPC) patients and 315 controls (normal and patients with other tumors). MA-IgA antibody was positive in 96.8% of the pretreatment NPC patients with a GMT of 1:36.3. MA-IgA detection by this method was more sensitive than EA-IgA detection by IE. In contrast patients with tumors other than NPC were negative for MA-IgA antibody. 9.1% of VCA-IgA positive persons were MA-IgA positive with a GMT of less than 1:5. No MA-IgA positive was found in VCA-IgA negatives. The results indicated that this method was relatively specific. In the treatment group the positive rate and GMT of MA-IgA antibody declined with increase in survival time and the decline was faster than VCA-IgA. When recurrence or distant metastasis developed similar to VCA-IgA and EA-IgA antibodies the positive rate and GMT of MA-IgA antibody increased to its pretreatment level. Therefore MA-IgA detection might be valuable in the early diagnosis and monitor of NPC.

With gene engineering eb virus membrane antigen as the diagnostic antigen, indirect immunofluo-rescence (IF) assay was used to detect iga antibody against eb virus membrane antigen (ma-iga) in sera from 202 nasopharyngeal carcinoma (NPC) patients and 315 controls (normal and patients with other tumors). ma-iga antibody was positive in 96.8% of the pretreatment NPC patients with a GMT of 1:36.3. ma-iga detection by this method was more sensitive than EA-iga detection by IE. In contrast, patients with tumors other than NPC were negative for ma-iga antibody. 9.1% of VCA-iga positive persons were ma-iga positive with a GMT of less than 1:5. No ma-iga positive was found in VCA-iga negatives. The results indicated that this method was relatively specific. In the treatment group, the positive rate and GMT of ma-iga antibody declined with increase in survival time and the decline was faster than VCA-iga. When recurrence or distant metastasis developed, similar to VCA-iga and EA-iga antibodies, the positive rate and GMT of ma-iga antibody increased to its pretreatment level. Therefore, ma-iga detection might be valuable in the early diagnosis and monitor of NPC.

关键词： iga COMPARISON WITH VCA-iga AND EA-iga ANTIBODIES gene engineering eb virus membrane antigen in detection of ma-iga antibody VCA ma EA

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