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Cell Research 2002年第1期12卷 19-32页

作者： CHRIS KIANI, LIWEN CHEN, YAO JIONg WU, ALBERT J YEE, BURTON B YANg, Sunnybrook and Women’s College Health Sciences Centre and Department of Laboratory Medicine and Patobiology, 2 Department of Surgeny, Faculty of Medicine, University of Toronto, Canada Sunnybrook and Women' s College Health Sciences Centre and Department of Laboratory Medicine and Pathobiology University of Toronto Canada Sunnybrook and Women' s College Health Sciences Centre and Department of Surgeny Faculty of Medicine University of Toronto Canada

Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties. It is also crucial in chondroskeletal morphogenesis during development. Aggrecan is a multimodular molecule expressed by chondrocytes. Its core protein is composed of three globular domain. (g1, g2, and g3) and a large extended region (CS) between g2 and g3 for glycosaminoglycan chain attachment. g1 comprises the amino terminus of the core protein. This domain.has the same structural motif as link protein. Functionally, the g1 domain.interacts with hyaluronan acid and link protein, forming stable ternary complexes in the extracellular matrix. g2 is homologous to the tandem repeats of g1 and of link protein and is involved in product processing. g3 makes up the carboxyl terminus of the core protein. It enhances glycosaminoglycan modification and product secretion. Aggrecan plays an important role in mediating chondrocyte-chondrocyte and chondrocyte-matrix interactions through its ability to bind hyaluronan.

关键词： Proteoglycan chondroitin sulfate glycosaminoglycan g1 domain g3 domain.

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