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Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer

World Journal of gastroenterology 2022年第32期28卷 4649-4667页

作者： Tomoyuki Fukami Atsushi shiozaki Toshiyuki Kosuga Michihiro Kudou Hiroki shimizu Takuma Ohashi Tomohiro Arita Hirotaka Konishi shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Yukiko Morinaga Eiichi Konishi Eigo Otsuji Division of Digestive surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Pathology Kyoto City HospitalKyoto 604-8845Japan Department of Pathology Kyoto Prefectural University of MedicineKyoto 602-8566Japan

BACKgROUND Anoctamin 5(ANO5)/transmembrane protein 16E belongs to the ANO/transmembrane protein 16 anion channel *** comprise a family of plasma membrane proteins that mediate ion transport and phospholipid scrambling and regulate other membrane proteins in numerous cell *** studies have elucidated the roles and mechanisms of ANO5 activation in various cancer ***,it remains unclear whether ANO5 acts as a plasma membrane chloride channel,and its expression and functions in gastric cancer(gC)have not been *** To examine the role of ANO5 in the regulation of tumor progression and clinicopathological significance of its expression in *** Knockdown experiments using ANO5 small interfering RNA were conducted in human gC cell lines,and changes in cell proliferation,cell cycle progression,apoptosis,and cellular movement were *** gene expression profiles of gC cells were investigated following ANO5 silencing by microarray *** staining of ANO5 was performed on 195 primary tumor samples obtained from patients with gC who underwent curative gastrectomy between 2011 and 2013 at our *** Reverse transcription-quantitative polymerase chain reaction(PCR)and western blotting demonstrated high ANO5 mRNA and protein expression,respectively,in NUgC4 and MKN45 *** these cells,ANO5 silencing inhibited cell proliferation and induced *** addition,the knockdown of ANO5 inhibited g1-s phase progression,invasion,and *** results of the microarray analysis revealed changes in the expression levels of several cyclin-associated genes,such as CDKN1A,CDK2/4/6,CCNE2,and E2F1,in ANO5-depleted NUgC4 *** expression of these genes was verified using reverse transcription-quantitative *** staining revealed that high ANO5 expression levels were associated with a poor *** analysis identified high ANO5 expression as an independent prognostic fa

关键词： Anoctamin 5 gastric cancer Cell cycle g1/s checkpoint Cell proliferation

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Crosstalk between cell fate and survival pathways during uterine cervical carcinoma progression: a molecular and clinical perspective

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Journal of Cancer Metastasis and Treatment 2023年第1期9卷 75-93页

作者： sudip samadder Palash Paul Arpan De Department of Microbiology Vijaygarh Jyotish Ray CollegeKolkata 700032India Department of Neurosurgery Brain Tumor CenterThe University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

The development of uterine cervical cancer is primarily attributed to infection by high-risk human papillomaviruses(HR-HPVs).E5,E6 and E7,the three early oncoproteins of HR-HPVs,have been implicated in initiation and progression of cervical *** intricate molecular mechanisms that orchestrate aberrant cellular transformations to establish carcinoma of the cervical epithelium following viral infections are poorly ***,we discuss how deregulation of three major cell fate regulatory pathways,Hedgehog,Wnt and Notch,and cell survival strategies involving EgFR signaling and g1/s checkpoint contribute towards cervical cancer development and *** exploration of protein interaction database has revealed several genes that are involved in cervical cancer initiation and progression,and the two crucial"driver"genes,MYC and CTNNB1(β-catenin),have been identified as major players in protein-protein interaction ***3βemerged as the key mediator of crosstalk between Hedgehog,Wnt and Notch signaling ***3βregulates cytoplasmic stabilization and nuclear translocation ofβ-catenin,which further impacts the expression of MYC,critical for cell cycle ***,our analyses suggest that combinatorial therapeutic targeting of these proteins may be more effective in blocking cervical cancer initiation and progression.

关键词： Uterine cervical cancer hedgehog Notch Wnt g1/s checkpoint gsK3β β-catenin MYC

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