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Kisspeptin regulates gonadotropin-releasing hormone secretion in gonadotropin-releasing hormone/enhanced green fluorescent protein transgenic rats

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Neural Regeneration Research 2013年第2期8卷 162-168页

作者： Haogang Xue Chunying Yang Xiaodong ge Weiqi Sun Chun Li Mingyu Qi Department of Orthopedic Surgery First Clinical Hospital Beihua University

Kisspeptin is essential for activation of the hypothalamo-pituitary-gonadal axis. In this study, we established gonadotropin-releasing hormone/enhanced green fluorescent protein transgenic rats. Rats were injected with 1, 10, or 100 pM kisspeptin-10, a peptide derived from full-length kisspeptin, into the arcuate nucleus and medial preoptic area, and with the kJsspeptJn antagonist peptJde 234 into the lateral cerebral ventricle. The results of immunohistochemical staining revealed that pulsatile luteinizing hormone secretion was suppressed after injection of antagonist peptide 234 into the lateral cerebral ventricle, and a significant increase in luteinizing hormone level was observed after kisspeptin-10 injection into the arcuate nucleus and medial preoptic area. The results of an enzyme-linked immunosorbent assay showed that luteinizing hormone levels during the first hour of kisspeptin-10 infusion into the arcuate nucleus were significantly greater in the 100 pM kisspeptin-10 group than in the 10 pM kisspeptin-10 group. These findings indicate that kisspeptin directly promotes gonadotropin-releasing hormone secretion and luteinizing hormone release in gonadotropin-releasing hormone/enhanced green fluorescent protein transgenic rats. The arcuate nucleus is a key component of the kisspeptin-g protein-coupled receptor 54 signaling pathway underlying regulating luteinizing hormone pulse secretion.

关键词： neural regeneration basic research gonadotropin-releasing hormone enhanced green fluorescentprotein transgenic luteinizing hormone g protein-coupled receptor 54 medial preoptic area arcuate nucleus anteroventral periventricular nucleus organum vasculosum of the laminaterminalis photographs-containing paper neuroregeneration

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