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fuzi promoted the formation of myelin sheath in Schwann cells induced by high glucose

中国药理学与毒理学杂志 2015年第S1期29卷 43-43页

作者： Tian-tianLYU JingHAN Hong-liangWANG YanWU Gai-meiHAO JieHE WeiWANG Beijing University of Chinese Medicine Beijing 100029 China

OBJECTIVE Diabetic peripheral neuropathy(DPN)is the cause of considerable morbidity and mortality indiabetic *** loss of nerve fibersis the main pathological characteristics of the DPN and the pathway of Oct6-Krox20 plays an important role in the formation of myelin *** our previous study,we found that fuzi(Radix aconite lateral ispreparata)could significantly improve the nerve conduction deficits and thermal hypoalgesia deficits in the diabetic rats,but the underlying molecular mechanisms have not been *** aim of this study is to investigate the expression of Oct6,Krox20,myelin basic protein(Mbp)and myelin protein zero(Mpz)in Schwann cells and analyze the effect of fuzi in the formation of myelin *** There were six groups in the *** the control group,thecells weresupplemented with normal cell culture *** the mannitol group,the cells were fed with normal glucose plus *** the model group,the cells were supplemented with high glucose medium(75 mmol·L-1).In the other group,the cells weretreated with high glucose medium(75mmol·L-1)plus different concentrations of fuzi(0.1,1.0 and 10.0μg·mL-1).After three days,real-time PCR was used to detect gene *** Compared with the control group,the model group showed lowerexpression of Oct6,Krox20,Mbp and *** comparison to the model group,fuzi(0.1,1.0and 10.0μg·mL-1)increased the expression of Oct6,Krox20,Mbp and *** These results demonstrate that fuzi enhances the protein of myelin sheath through impacting the pathway of Oct6-Krox20.

关键词： fuzi Schwann cells Oct6 Krox20

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Roles of three classic TCM formulae in inhibiting gastric cancer growth in mice

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Journal of Traditional Chinese Medical Sciences 2017年第1期4卷 65-70页

作者： Liyun Yue Changle Zhu Chong Gao Chong Wang Xinyi Chen Tongde Tian Department of Hematology and Oncology Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBeijing 100700China Integrated TCM&Western Medicine Department Henan Cancer HospitalZhengzhou 450000China

Objective:To explore the effects of three classic traditional Chinese medicine (TCM) formulae,Dahuang Huanglian Xiexin Decoction (DHXD),fuzi Lizhong pills (FLP) and Liushen pills (LSP),in suppressing gastric cancer growth in mice and provide evidence for their clinical ***:MGC-803 cells (5 × 106 per mouse) were injected into the subcutaneous tissues of the neck and back of nude *** week later,the mice were divided into three batches (9 total groups) based on tumor size and a random number *** each batch,the mice were subdivided into control,low-and high-dose groups for the three classic *** 21-d treatment,the mice were observed for their general conditions,and then *** tissues were harvested and weighed,and the tumor inhibition rate was ***:Compared with the control group,body weight in the low-and high-dose DHXD and FLP groups showed no significant change (P >.05),while the high-dose LSP group had significantly lower body weight (P =.049).Compared with the control group,the low-and high-dose DHXD groups showed no significant inhibitory effect on xenograft tumor growth (P >.05);lowdose FLP showed an inhibitory effect on tumor growth (P =.039),while high-dose LSP had a more significant effect (P =.004).Conclusions:DHXD did not inhibit xenograft tumor growth in *** contrast,low-dose FLP had a measurable inhibitory effect,and high-dose LSP more significantly suppressed xenograft tumor growth in mice.

关键词： Dahuang Huanglian Xiexin Decoction fuzi Lizhong pills Liushen pills Gastric cancer Tumor inhibition rate

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